Tumor Vascularization Book

Tumor Vascularization


  • Author : Domenico Ribatti
  • Publisher : Academic Press
  • Release Date : 2020-01-21
  • Genre: Science
  • Pages : 198
  • ISBN 10 : 9780128194942
  • Total Read : 95
  • File Size : 17,9 Mb

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Tumor Vascularization Summary:

Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels. Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment

Tumour Angiogenesis Book

Tumour Angiogenesis


  • Author : R. John Bicknell
  • Publisher : Oxford University Press, USA
  • Release Date : 1997
  • Genre: Medical
  • Pages : 416
  • ISBN 10 : UOM:39015041324271
  • Total Read : 89
  • File Size : 20,5 Mb

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Tumour Angiogenesis Summary:

This is the first comprehensive book to cover all areas of a rapidly expanding research area. Each chapter is written by world experts in the field and topics covered include in vivo models, mechanisms, inhibition, and the role of macrophages, cytokines, proteases, extracellular matrix components, nitric oxide, prostanoids and oncogenes/tumour suppressor genes in angiogenesis. Other chapters examine the role of specific growth factors in angiogenesis, including vascular endothelial growth factor, the basic fibroblast growth factor family, transforming growth factor-beta, tumour necrosis factor-alpha, platelet-derived endothelial cell growth factor/thymidine phosphorylase and pleiotrophin and related molecules. Clinical issues are addressed in chapters that deal with the prognostic and predictive value of tumor microvessel density and the therapeutic significance of microregional blood flow. The two final chapters examine the feasibility of targeting tumour vasculature using either antibodies or gene therapy.

Tumor Angiogenesis Book

Tumor Angiogenesis


  • Author : Dieter Marmé
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-12-05
  • Genre: Medical
  • Pages : 845
  • ISBN 10 : 9783540331773
  • Total Read : 62
  • File Size : 9,6 Mb

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Tumor Angiogenesis Summary:

Tumor angiogenesis is one of the most prominent mechanisms driving tumor development and progression. This book is written by internationally renowned experts. Part 1 describes the basic mechanisms. Tumor-angiogenic signaling pathways are presented as new potential targets for anti-angiogenic therapy. Part 2 reviews the efforts made to validate new targets and to show efficacy in animals. Part 3 is devoted to the clinical development of the novel anti-angiogenic drugs and their use in clinical practice.

Proteases and Their Inhibitors in Cancer Metastasis Book

Proteases and Their Inhibitors in Cancer Metastasis


  • Author : J-M. Foidart
  • Publisher : Springer Science & Business Media
  • Release Date : 2002
  • Genre: Medical
  • Pages : 259
  • ISBN 10 : 9781402009235
  • Total Read : 63
  • File Size : 18,7 Mb

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Proteases and Their Inhibitors in Cancer Metastasis Summary:

In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. For most of these proteases, their expression is a reliable indication of ongoing tissue remodeling. This book provides a comprehensive evaluation of the mechanisms of action of proteases and their inhibitors in tumor biology. The first part provides the reader with a selective overview of the molecular biology of serine proteases, MMPs and their physiological inhibitors. The most important proteases and their physiological as well as synthetic inhibitors are evaluated in the most relevant models of experimental and human cancer. The clinical aspects are also taken into account. This volume offers an update on this challenging aspect of cancer treatment, its interest bias, and possible clinical implication.

In Vivo Models to Study Angiogenesis Book

In Vivo Models to Study Angiogenesis


  • Author : Domenico Ribatti
  • Publisher : Academic Press
  • Release Date : 2017-08-18
  • Genre: Science
  • Pages : 112
  • ISBN 10 : 9780128140215
  • Total Read : 80
  • File Size : 9,7 Mb

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In Vivo Models to Study Angiogenesis Summary:

In Vivo Models to Study Angiogenesis provides the latest information and an overview of the most common assays for studying angiogenesis in vivo. Under physiological conditions, angiogenesis is tightly controlled, whereas increased production of angiogenic stimuli and/or reduced production of angiogenic inhibitors leads to abnormal neovascularization, such as occurs in cancer, chronic inflammatory disease, diabetic retinopathy, macular degeneration and cardiovascular disorders. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system. This book presents the latest information from the extensive literature and research available. Evidence is now emerging that blood vessels themselves have the ability to provide instructive regulatory signals to surrounding non-vascular target cells during organ development. Thus, endothelial cell signaling is currently believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodeling. Provides information on the most common assays to study angiogenesis in vivo Presents an ideal reference for those interested in angiogenesis as a normal and vital process in growth and development Covers wound healing, the formation of granulation tissue, and the transition of tumors from benign to malignant

Physiologic and Pathologic Angiogenesis Book

Physiologic and Pathologic Angiogenesis


  • Author : Dan Simionescu
  • Publisher : BoD – Books on Demand
  • Release Date : 2017-04-05
  • Genre: Medical
  • Pages : 466
  • ISBN 10 : 9789535130239
  • Total Read : 69
  • File Size : 10,9 Mb

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Physiologic and Pathologic Angiogenesis Summary:

The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that this book will become a source of inspiration and novel ideas for all.

Diagnostics of Vascular Diseases Book

Diagnostics of Vascular Diseases


  • Author : Peter Lanzer
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Medical
  • Pages : 362
  • ISBN 10 : 9783642605123
  • Total Read : 64
  • File Size : 12,8 Mb

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Diagnostics of Vascular Diseases Summary:

This textbook systematically reviews the working principles and modes of application of techniques applicable to noninvasive and invasive vascular examinations. The authors cover the essential physical and/or chemical principles of each diagnostic modality and so derive the characteristics of the diagnostic instrumentation. Physicians thus learn how to translate advanced technology into optimum diagnostic efficacy in daily clinical routine.