Total Synthesis of Bioactive Natural Products by Palladium Catalyzed Domino Cyclization of Allenes and Related Compounds Book

Total Synthesis of Bioactive Natural Products by Palladium Catalyzed Domino Cyclization of Allenes and Related Compounds


  • Author : Shinsuke Inuki
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-11-23
  • Genre: Science
  • Pages : 106
  • ISBN 10 : 4431540431
  • Total Read : 75
  • File Size : 15,8 Mb

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Total Synthesis of Bioactive Natural Products by Palladium Catalyzed Domino Cyclization of Allenes and Related Compounds Summary:

The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26% overall yield in seven steps), lysergic acid (4.0% overall yield in fifteen steps), lysergol (3.6% overall yield in fifteen steps) and isolysergol (8.2% overall yield in eleven steps) have been achieved. These are more facile synthetic route than those previously reported. These findings would contribute to the development of efficient synthetic methods for biologically active compounds containing a complex structure.

Bioactive Natural Products Book

Bioactive Natural Products


  • Author : Goutam Brahmachari
  • Publisher : World Scientific
  • Release Date : 2012
  • Genre: Science
  • Pages : 695
  • ISBN 10 : 9789814335379
  • Total Read : 89
  • File Size : 14,6 Mb

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Bioactive Natural Products Summary:

Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations.

Total Synthesis of Natural Products Book

Total Synthesis of Natural Products


  • Author : Jie Jack Li
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-03-14
  • Genre: Science
  • Pages : 279
  • ISBN 10 : 9783642340659
  • Total Read : 99
  • File Size : 15,6 Mb

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Total Synthesis of Natural Products Summary:

'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.

Total Synthesis of Bioactive Natural Products by Palladium Catalyzed Domino Cyclization of Allenes and Related Compounds Book

Total Synthesis of Bioactive Natural Products by Palladium Catalyzed Domino Cyclization of Allenes and Related Compounds


  • Author : Shinsuke Inuki
  • Publisher : Springer
  • Release Date : 2016-05-01
  • Genre: Science
  • Pages : 124
  • ISBN 10 : 4431561102
  • Total Read : 83
  • File Size : 13,8 Mb

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Total Synthesis of Bioactive Natural Products by Palladium Catalyzed Domino Cyclization of Allenes and Related Compounds Summary:

This book details efficient synthetic approaches for biologically active compounds. It describes novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino cyclization of allenes and related compounds.

Efficiency in Natural Product Total Synthesis Book

Efficiency in Natural Product Total Synthesis


  • Author : Pei-Qiang Huang
  • Publisher : John Wiley & Sons
  • Release Date : 2018-07-24
  • Genre: Science
  • Pages : 512
  • ISBN 10 : 9781118940211
  • Total Read : 75
  • File Size : 11,9 Mb

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Efficiency in Natural Product Total Synthesis Summary:

Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. • Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science • Describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis • Appeals to graduate students with two sections at the end of each chapter illustrating key reactions, strategies, tactics, and concepts; and good but unfinished total synthesis (synthesis of core structure) before the last section • Compiles examples of solid phase synthesis and continuing flow chemistry-based total synthesis which are very relevant and attractive to industry R&D professionals

Modern Sustainable Techniques in Total Synthesis of Bioactive Natural Products Book

Modern Sustainable Techniques in Total Synthesis of Bioactive Natural Products


  • Author : Sasadhar Majhi
  • Publisher : Unknown
  • Release Date : 2023-04-24
  • Genre: Uncategoriezed
  • Pages : 0
  • ISBN 10 : 9811268681
  • Total Read : 93
  • File Size : 20,5 Mb

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Modern Sustainable Techniques in Total Synthesis of Bioactive Natural Products Summary:

Modern Sustainable Techniques in Total Synthesis of Bioactive Natural Products comprises five parts for green tools, such as ultrasonic waves, microwave heating, visible-light photochemistry, organic electrochemistry, and flow chemistry, along with 72 chapters for each bioactive molecule of natural origin. Each chapter explores the natural source, structure, systematic name, structural features, compound class, biological activity, conventional approaches for their chemical synthesis, and demerit(s) of conventional approaches (where applicable). Finally, critical features of total synthesis using modern sustainable techniques, including reaction types, synthetic strategy, and synthetic route utilizing modern sustainable tools for each bioactive natural product and secondary metabolites, are discussed brilliantly. The spectrum of application of total synthesis of bioactive natural products using modern sustainable techniques may promote the development of more eco-friendly synthetic processes so that the next generations can live on this planet with a minimum energy requirement for chemical reactions with the least pollution.

Total Synthesis of Bioactive Natural Products Book

Total Synthesis of Bioactive Natural Products


  • Author : Goutam Brahmachari
  • Publisher : Elsevier
  • Release Date : 2019-04-27
  • Genre: Science
  • Pages : 350
  • ISBN 10 : 9780081028230
  • Total Read : 67
  • File Size : 16,7 Mb

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Total Synthesis of Bioactive Natural Products Summary:

Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear illustrations throughout, making this book an essential and practical guide for anyone working with both synthesis and natural products. Provides individual outlines for the total synthesis of approximately 100 bioactive natural molecules Outlines each step of the process in detail, with full experimental information supported by extensive schemes Includes retrosynthetic analyses, reaction sequences and stereochemically crucial steps for each molecule