The Molecular Switch

The Molecular Switch

• Author : Rob Phillips
• Publisher : Princeton University Press
• File Size : 5,9 Mb
• Release Date : 2020-09
• Genre: Science
• Pages : 436
• ISBN 10 : 9780691200248

Download The Molecular Switch Book in PDF and ePub

A signature feature of living organisms is their ability to carry out purposeful actions by taking stock of the world around them. To that end, cells have an arsenal of signaling molecules linked together in signaling pathways, which switch between inactive and active conformations. The Molecular Switch articulates a biophysical perspective on signaling, showing how allostery—a powerful explanation of how molecules function across all biological domains—can be reformulated using equilibrium statistical mechanics, applied to diverse biological systems exhibiting switching behaviors, and successfully unify seemingly unrelated phenomena. Rob Phillips weaves together allostery and statistical mechanics via a series of biological vignettes, each of which showcases an important biological question and accompanying physical analysis. Beginning with the study of ligand-gated ion channels and their role in problems ranging from muscle action to vision, Phillips then undertakes increasingly sophisticated case studies, from bacterial chemotaxis and quorum sensing to hemoglobin and its role in mammalian physiology. He looks at G-protein coupled receptors as well as the role of allosteric molecules in gene regulation. Phillips concludes by surveying problems in biological fidelity and offering a speculative chapter on the relationship between allostery and biological Maxwell demons. Appropriate for graduate students and researchers in biophysics, physics, engineering, biology, and neuroscience, The Molecular Switch presents a unified, quantitative model for describing biological signaling phenomena.

Molecular Switches

• Author : Ben L. Feringa
• Publisher : John Wiley & Sons
• File Size : 15,8 Mb
• Release Date : 2011-08-04
• Genre: Science
• Pages : 824
• ISBN 10 : 9783527634415

Download Molecular Switches Book in PDF and ePub

The long-awaited second edition of the successful book covering molecular switches now in two volumes! Providing principles and applications this book brings you everything you need to know about molecular switches - a hot topic in the nanoworld. The major classes of molecular switches including catenanes, rotaxanes, azobenzenes together with polymer and biomolecular switching systems and DNA based switches are covered. Chemists and material scientists interested in one of the most innovative areas of their science will benefit greatly from reading this book. "This book will appeal most to organic chemists, because of the way new structures are introduced through their synthesis, but it will also provide a useful introduction for other scientists, provided they are conversant with molecular structures." (Organic and Biomolecular Chemistry) "... a comprehensive and up-to-date insight ..." (Chemistry & Industry)

The Molecular Switch

• Author : Rob Phillips
• Publisher : Princeton University Press
• File Size : 5,5 Mb
• Release Date : 2020-08-18
• Genre: Science
• Pages : null
• ISBN 10 : 9780691200255

Download The Molecular Switch Book in PDF and ePub

A signature feature of living organisms is their ability to carry out purposeful actions by taking stock of the world around them. To that end, cells have an arsenal of signaling molecules linked together in signaling pathways, which switch between inactive and active conformations. The Molecular Switch articulates a biophysical perspective on signaling, showing how allostery—a powerful explanation of how molecules function across all biological domains—can be reformulated using equilibrium statistical mechanics, applied to diverse biological systems exhibiting switching behaviors, and successfully unify seemingly unrelated phenomena. Rob Phillips weaves together allostery and statistical mechanics via a series of biological vignettes, each of which showcases an important biological question and accompanying physical analysis. Beginning with the study of ligand-gated ion channels and their role in problems ranging from muscle action to vision, Phillips then undertakes increasingly sophisticated case studies, from bacterial chemotaxis and quorum sensing to hemoglobin and its role in mammalian physiology. He looks at G-protein coupled receptors as well as the role of allosteric molecules in gene regulation. Phillips concludes by surveying problems in biological fidelity and offering a speculative chapter on the relationship between allostery and biological Maxwell demons. Appropriate for graduate students and researchers in biophysics, physics, engineering, biology, and neuroscience, The Molecular Switch presents a unified, quantitative model for describing biological signaling phenomena.

Molecular Biology of the Cell

• Author : Bruce Alberts
• Publisher : Unknown
• File Size : 16,8 Mb
• Release Date : 2004
• Genre: Cells
• Pages : 0
• ISBN 10 : 0815332181

Download Molecular Biology of the Cell Book in PDF and ePub

Spin Crossover in Transition Metal Compounds III

• Author : Philipp Gütlich
• Publisher : Springer Science & Business Media
• File Size : 19,6 Mb
• Release Date : 2004-08-17
• Genre: Science
• Pages : 294
• ISBN 10 : 3540403957

Download Spin Crossover in Transition Metal Compounds III Book in PDF and ePub

C. Brady, J.J. McGarvey, J.K. McCusker, H. Toftlund, D.N. Hendrickson: Time-Resolved Relaxation Studies of Spin Crossover Systems in Solution.- V. Ksenofontov, P. Gütlich et al.: Spin Crossover under Pressure.- A. Bousseksou, F. Varret, M. Goiran, K. Boukheddaden, J.P. Tuchagues: The Spin Crossover Phenomenon under High Magnetic Field.- J.-P. Tuchagues, A. Bousseksou, G. Molnár, J.J. McGarvey, F. Varret: The Role of Molecular Vibrations in the Spin Crossover Phenomenon.- W. Linert, M. Grunert, A.B. Koudriavtsev: Isokinetic and Isoequilibrium Relationships in Spin Crossover Systems.- H. Winkler, A.I: Chumakov, A.X. Trautwein: Nuclear Resonant Forward and Nuclear Inelastic Scattering Using Synchrotron Radiation for Spin Crossover Systems.- M. Sorai: Heat Capacity Studies of Spin Crossover Systems.- H. Spiering et al.: Cooperative Elastic Interactions in Spin Crossover Systems.- H. Paulsen, A.X. Trautwein: Density Functional Theory Calculations for Spin Crossover Complexes.- J.-F. Létard, P. Guionneau, L. Goux-Capes: Towards Spin Crossover Applications.

Springer Handbook of Nanotechnology

• Author : Bharat Bhushan
• Publisher : Springer Science & Business Media
• File Size : 14,9 Mb
• Release Date : 2004-01-19
• Genre: Technology & Engineering
• Pages : 1232
• ISBN 10 : 9783540012184

Download Springer Handbook of Nanotechnology Book in PDF and ePub

This major work has established itself as the definitive reference in the nanoscience and nanotechnology area in one volume. In presents nanostructures, micro/nanofabrication, and micro/nanodevices. Special emphasis is on scanning probe microscopy, nanotribology and nanomechanics, molecularly thick films, industrial applications and microdevice reliability, and on social aspects. Reflecting further developments, the new edition has grown from six to eight parts. The latest information is added to fields such as bionanotechnology, nanorobotics, and NEMS/MEMS reliability. This classic reference book is orchestrated by a highly experienced editor and written by a team of distinguished experts for those learning about the field of nanotechnology.

Molecular Biology of B Cells

• Author : Michael Reth
• Publisher : Elsevier
• File Size : 12,5 Mb
• Release Date : 2004-02-19
• Genre: Medical
• Pages : 600
• ISBN 10 : 0080479502

Download Molecular Biology of B Cells Book in PDF and ePub

Molecular Biology of B Cells is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding of complex phenotyes. The molecular basis of many diseases due to B cell abnormality is also discussed. This definitive reference is directed at research level immunologists, molecular biologists and geneticists.

Regulation of Entry Into Mitosis by a Multi state Molecular Switch

• Author : Stacy L. Harvey
• Publisher : Unknown
• File Size : 16,9 Mb
• Release Date : 2008
• Genre: Uncategoriezed
• Pages : 372
• ISBN 10 : UCAL:X79346

Download Regulation of Entry Into Mitosis by a Multi state Molecular Switch Book in PDF and ePub

Molecular and Nano Electronics Analysis Design and Simulation

• Author : Jorge M. Seminario
• Publisher : Elsevier
• File Size : 5,5 Mb
• Release Date : 2006-10-24
• Genre: Science
• Pages : 292
• ISBN 10 : 0080465838

Download Molecular and Nano Electronics Analysis Design and Simulation Book in PDF and ePub

The aim of Molecular and Nano Electronics: Analysis, Design and Simulation is to draw together contributions from some of the most active researchers in this new field in order to illustrate a theory guided-approach to the design of molecular and nano-electronics. The field of molecular and nano-electronics has driven solutions for a post microelectronics era, where microelectronics dominate through the use of silicon as the preferred material and photo-lithography as the fabrication technique to build binary devices (transistors). The construction of such devices yields gates that are able to perform Boolean operations and can be combined with computational systems, capable of storing, processing, and transmitting digital signals encoded as electron currents and charges. Since the invention of the integrated circuits, microelectronics has reached increasing performances by decreasing strategically the size of its devices and systems, an approach known as scaling-down, which simultaneously allow the devices to operate at higher speeds. * Provides a theory-guided approach to the design of molecular and nano-electronics * Includes solutions for researchers working in this area * Contributions from some of the most active researchers in the field of nano-electronics

Handbook of Single Molecule Electronics

• Author : Kasper Moth-Poulsen
• Publisher : CRC Press
• File Size : 19,6 Mb
• Release Date : 2016-01-05
• Genre: Science
• Pages : 448
• ISBN 10 : 9789814463393

Download Handbook of Single Molecule Electronics Book in PDF and ePub

Single-molecule electronics has evolved as a vibrant research field during the last two decades. The vision is to be able to create electronic components at the highest level of miniaturization—the single molecule. This book compiles and details cutting-edge research with contributions from chemists, physicists, theoreticians, and engineers. It covers all aspects of single-molecule electronics, from the theory through experimental realizations and the chemical synthesis of molecular components to the implementation of molecular components in future integrated circuits. This book describes in detail both established methods and recent advances in the field, including vibrational effects, switching phenomena, quantum interference, thermal power, and parallel assembly strategies. The authors add more details to the chapters than typically found in the primary literature so that the book can be read not only by specialists but also by non-experts and students with an interest in the research field. Each chapter is accompanied by problems, and a solutions manual is also provided.

Unimolecular and Supramolecular Electronics II

• Author : Robert M. Metzger
• Publisher : Springer Science & Business Media
• File Size : 14,6 Mb
• Release Date : 2012-01-10
• Genre: Science
• Pages : 283
• ISBN 10 : 9783642273971

Download Unimolecular and Supramolecular Electronics II Book in PDF and ePub

G. C. Solomon C. Herrmann M. A. Ratner Molecular Electronic Junction Transport: Some Pathways and Some Ideas R. M. Metzger D. L. Mattern Unimolecular Electronic Devices B. Branchi F. C. Simeone M. A. Rampi Active and Non-Active Large-Area Metal–Molecules–Metal Junctions C. Li A. Mishchenko T. Wandlowski Charge Transport in Single Molecular Junctions at the Solid/Liquid Interface K. W. Hipps Tunneling Spectroscopy of Organic Monolayers and Single Molecules N. Renaud M. Hliwa C. Joachim Single Molecule Logical Devices

The Power of Click Chemistry for Molecular Machines and Surface Patterning

• Author : Jason M. Spruell
• Publisher : Springer Science & Business Media
• File Size : 15,5 Mb
• Release Date : 2011-06-10
• Genre: Science
• Pages : 119
• ISBN 10 : 9781441996473

Download The Power of Click Chemistry for Molecular Machines and Surface Patterning Book in PDF and ePub

The union of covalent and noncovalent chemistries manifested in the mechanical bond represents one of the great chemical triumphs of the last half century. However, until recently, the preparation of mechanically interlocked compounds has often been an inefficient and limiting process. This thesis provides a detailed account of the great strides taken to increase the synthetic accessibility of donor-acceptor mechanically interlocked molecules by the application of highly efficient and ultra mild chemical transformations during their template-directed synthesis. These new departures in synthesis have indeed played a transformative role in that more complex, higher-order, and functional architectures – once only a dream – are now comfortably within reach. Specifically, the formation of mechanical bonds in higher order rotaxanes and catenanes has become ever easier through the use of highly efficient click chemistries. The resulting mechanically interlocked compounds are functional molecular media for a host of applications including information storage, mechanical actuation, and drug release.

Molecular Motors

• Author : Manfred Schliwa
• Publisher : John Wiley & Sons
• File Size : 16,6 Mb
• Release Date : 2006-03-06
• Genre: Science
• Pages : 604
• ISBN 10 : 9783527605651

Download Molecular Motors Book in PDF and ePub

The latest knowledge on molecular motors is vital for the understanding of a wide range of biological and medical topics: cell motility, organelle movement, virus transport, developmental asymmetry, myopathies, and sensory defects are all related to the function or malfunction of these minute molecular machines. Since there is a vast amount of information on motor mechanisms and potential biomedical and nanobiotechnological applications, this handbook fulfills the need for a collection of current research results on the functionality, regulation, and interactions of cytoskeletal, DNA, and rotary motors. Here, leading experts present a concise insight, ranging from atomic structure, biochemistry, and biophysics to cell biology, developmental biology and pathology. Basic principles and applications make this book a valuable reference tool for researchers, professionals, and clinicians alike - all set to become a "classic" in the years to come.

Molecular Nanowires and Other Quantum Objects

• Author : Alexandre S. Alexandrov
• Publisher : Springer Science & Business Media
• File Size : 5,9 Mb
• Release Date : 2004-04-30
• Genre: Technology & Engineering
• Pages : 428
• ISBN 10 : 9781402020933

Download Molecular Nanowires and Other Quantum Objects Book in PDF and ePub

There is a growing understanding that the progress of the conventional silicon technology will reach its physical, engineering and economic limits in near future. This fact, however, does not mean that progress in computing will slow down. What will take us beyond the silicon era are new nano-technologies that are being pursued in university and corporate laboratories around the world. In particular, molecular switching devices and systems that will self-assemble through molecular recognition are being designed and studied. Many labora tories are now testing new types of these and other reversible switches, as well as fabricating nanowires needed to connect circuit elements together. But there are still significant opportunities and demand for invention and discovery be fore nanoelectronics will become a reality. The actual mechanisms of transport through molecular quantum dots and nanowires are of the highest current ex perimental and theoretical interest. In particular, there is growing evidence that both electron-vibron interactions and electron-electron correlations are impor tant. Further progress requires worldwide efforts of trans-disciplinary teams of physicists, quantum chemists, material and computer scientists, and engineers.

Dekker Encyclopedia of Nanoscience and Nanotechnology

• Author : James A. Schwarz
• Publisher : CRC Press
• File Size : 14,5 Mb
• Release Date : 2004
• Genre: Technology & Engineering
• Pages : 974
• ISBN 10 : 0824750497

Download Dekker Encyclopedia of Nanoscience and Nanotechnology Book in PDF and ePub