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The information that modern humans need to know to get healthy and stay healthy in a wireless world, disconnected from Nature.
Mitochondria are intracellular organelles that power the cell by metabolizing glucose and other energy sources to generate ATP. They are also critical in programmed cell death, and dysfunction of mitochondrial components is implicated in numerous muscle and neurodegenerative disorders, including Parkinson's disease. This volume contains contributions examining the evolution and normal function of mitochondria in cells, as well as their roles in various pathologies.
Learn how corruption of the gut microbiome causes the mental and physical diseases of modern man.
Phase transitions occur throughout nature. The most familiar example is the one that occurs in water – the abrupt, discontinuous transition from a liquid to a gas or a solid, induced by a subtle environmental change. Practically magical, the ever-so-slight shift of temperature or pressure can induce an astonishing transition from one entity to another entity that bears little resemblance to the first. So "convenient" a feature is seen throughout the domains of physics and chemistry, and one is therefore led to wonder whether it might also be common to biology. Indeed, many of the most fundamental cellular processes are arguably attributable to radical structural shifts triggered by subtle changes that cross a critical threshold. These processes include transport, motion, signaling, division, and other fundamental aspects of cellular function. Largely on the basis of this radical concept, a symposium was organized in Poitiers, France, to bring together people who have additional evidence for the role of phase transitions in biology, and this book is a compendium of some of the more far-reaching of those presentations, as well as several others that seemed to the editors to be compelling. The book should be suitable for anyone interested in the nature of biological function, particularly those who tire of lumbering along well trodden pathways of pursuit, and are eager to hear something fresh. The book is replete with fresh interpretations of familiar phenomena, and should serve as an excellent gateway to deeper understanding.
What exactly is "biohacking"? Biohacking is just a fancy word for optimizing your own biological potential, and in the context of this brand new book from James Lee (author of The Methuselah Project) it means achieving this via - - Slowing the process of cellular aging to extend longevity - Whether by reducing oxidative stress, activating sirtuins, preventing inflammation or by just simply connecting with those around you (Having rich social connections with those around you is one of the strongest predictors of long life) - Understanding your own neurochemistry to enable you to address any underlying issues or dysfunction involving neurotransmitters such as serotonin, dopamine or even acetylcholine - Utilising the latest "nootropic" brain-boosting supplements and drugs to optimise memory and cognitive function - Never heard of racetams, EGCG, sulbutiamine or modafinil? Not for long. The Biohacking Manifesto is, at its heart, a compendium of Lee's previous books The Methuselah Project, Your Brain Electric and Brain Hacks. However rather than just cobble these together and slap on a new cover, he has headed back into the clinical trial papers and the latest research from cutting edge biotechs to discover some brand new exclusive material for this book. The Biohacking Manifesto includes - - An exhaustive coverage of the latest supplements including - curcumin, astaxanthin and nicotinamide riboside (to name a few) - A comprehensive guide to the fundamentals of neurochemistry, including a range of options for boosting neurotransmitters such as serotonin, dopamine and acetylcholine - An explanation of the various processes which underlie the aging process including - oxidative stress, inflammation and mitochondrial dysfunction - Everything you need to know if you want to live to 100 and beyond As a collected body of work, The Biohacking Manifesto gives you everything you need to know to enable you to put together a comprehensive strategy for living a long, happy and heal
Based on breakthrough new science in the field of hydration, Quench debunks many popular myths about "getting enough water" and offers a revolutionary five-day jump start plan that shows how better hydration can reduce or eliminate ailments like chronic headaches, weight gain, gut pain, and even autoimmune conditions. Chronic headaches, brain fog, fatigue, weight gain, insomnia, gut pain, autoimmune conditions. We may think these and other all-too-common modern maladies are due to gluten intake or too much sugar or too little exercise. But there is another missing piece to the health puzzle: Proper hydration. Yes, even in this era of Poland Spring many of us are dehydrated due to moisture-lacking diets, artificial environments, medications, and over-dependence on water as our only source of hydration. For this reason, that new diet or exercise plan may fail because our body doesn't have enough moisture to support it. Quench presents a wellness routine that can reverse all of that, based on breakthrough new science in the field of hydration. Readers will be surprised to learn that drinking too much water can flush out vital nutrients and electrolytes. Here is where "gel water" comes in: the water from plants (like cucumber, berries, aloe), which our bodies are designed to truly absorb right down to the cellular level. In fact, Ms. Bria's work as an anthropologist led her to the realization that desert people stay hydrated almost exclusively from what they eat, including gel plants like cactus. Based on groundbreaking science from the University of Washington's Pollack Water Lab and other research, Quench offers a five-day jump start plan: hydrating meal plans and the heart of the program, smoothies and elixirs using the most hydrating and nutrient-packed plants. Another unique feature of their approach is micro-movements -- small, simple movements you can make a few times a day that will move water through your fascia, the connective tissue responsible for hydrating
NATIONAL BESTSELLER A smart, research-driven case for why optimism, kindness, and strong social networks will help us live to 100. From the day her daughter was born, science journalist Marta Zaraska fretted about what she and her family were eating. She fasted, considered adopting the keto diet, and ran a half-marathon. She bought goji berries and chia seeds and ate organic food. But then her research brought her to read countless scientific papers and to interview dozens of experts in various fields of study, including molecular biochemistry, epidemiology and neuroscience. What Marta discovered shattered her long-held beliefs about aging and longevity. A strong support network of family and friends, she learned, lowers mortality risk by about 45 percent, while exercise only lowers it by about 23 percent. Volunteering your free time lowers it by 22 percent or so, while certain health fads like turmeric haven't been shown to help at all. These revelations led Marta Zaraska to a simple conclusion: In addition to healthy nutrition and physical activity, deepening friendships, practicing empathy and contemplating your purpose in life can improve your lifespan. Through eleven chapters that take her around the world, from catching wild mice in the woods of central England to flower arranging with octogenarians in Japan, from laboratories to "hugging centres," Marta embarks on an absorbing, entertaining and insightful journey to determine the habits that will have the greatest impact on our longevity. Deeply researched and expertly reported, Growing Young will dramatically change the way you seek a longer, happier life.
The Cushing's Syndrome Diet is filled with no nonsense recipes that will help control your Cushing's Syndrome symptoms. While there are many treatment options for Cushing's, only one is vital to insuring your overall health: a balanced, nutritional diet, low in salt and fat and high in protein and calcium. This type of diet can slow or prevent the loss of muscle and bone from Cushing's Syndrome. You'll find all of the recipes in this book provide you with maximum nutritional from plant sources-and they are quick and easy to prepare, so you can get back to living your life!
With information for patients and practitioners on optimizing mitochondrial function for greater health and longevity Why do we age? Why does cancer develop? What's the connection between heart failure and Alzheimer's disease, or infertility and hearing loss? Can we extend lifespan, and if so, how? What is the Exercise Paradox? Why do antioxidant supplements sometimes do more harm than good? Many will be amazed to learn that all these questions, and many more, can be answered by a single point of discussion: mitochondria and bioenergetics. In Mitochondria and the Future of Medicine, Naturopathic Doctor Lee Know tells the epic story of mitochondria, the widely misunderstood and often-overlooked powerhouses of our cells. The legendary saga began over two billion years ago, when one bacterium entered another without being digested, which would evolve to create the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that have been responsible for this life-giving energy. By understanding how our mitochondria work, in fact, it is possible to add years to our lives, and life to our years. Current research, however, has revealed a dark side: many seemingly disconnected degenerative diseases have tangled roots in dysfunctional mitochondria. However, modern research has also endowed us with the knowledge on how to optimize its function, which is of critical importance to our health and longevity. Lee Know offers cutting-edge information on supplementation and lifestyle changes for mitochondrial optimization, such as CoQ10, D-Ribose, cannabinoids, and ketogenic dietary therapy, and how to implement their use successfully. Mitochondria and the Future of Medicine is an invaluable resource for practitioners interested in mitochondrial medicine and the true roots of chronic illness and disease, as well as anyone interested in optimizing their health.
Did you know that mitochondrial health is an essential key to longevity and overall well-being? Mitochondria are often overlooked in the body's complex cellular structure. They may not get as much attention as the brain or heart, but they are integral to overall health just like any other organ, and your health can be affected by the inner workings of these tiny organelles. For example, when your cells don't use energy properly from food because they cannot metabolize glucose (a type of sugar), your mitochondria cellular structures stop functioning efficiently, resulting in insulin resistance as well-both upstream triggers for health problems like cardiovascular disease, diabetes, cancer, Alzheimer's Disease, Parkinson's Disease and much more. Fortunately, there are many steps that you can take to manage these mitochondrial dysfunctions through nutrition. That's why we have outlined a 3-weeks meal plan designed with your mitochondria in mind. First things first, it's a good idea to understand what mitochondria are and why they are vital for optimal health. Stay tuned for a deep dive into what they do, why you should care about them, and how you can take better care of them through nutrition. In this guide, you'll discover: What are mitochondria Diet tips to help improve your mitochondria function Symptoms you can tell your cellular structures are not working properly A seven-day weekly plan Sample recipes to follow Imagine what changes you can see in your life if you take action today. Scroll up and click buy now to get started.
Cody Wilson, a self-described crypto-anarchist and rogue thinker, combines the story of the production of the first ever 3D printable gun with a philosophical manifesto that gets to the heart of the twenty-first century debate over the freedom of information and ideas. Reminiscent of Steal This Book by Abbie Hoffman, Cody Wilson has written a philosophical guide through the digital revolution. Deflecting interference from the State Department and the Bureau of Alcohol, Tobacco, Firearms and Explosives, the story of Defense Distributed -- where Wilson's employees work against all odds to defend liberty and the right to access arms through the production of 3D printed firearms -- takes us across continents, into dusty warehouses and high rise condominiums, through television studios, to the Texas desert, and beyond.
The explosion of knowledge about satiety and hunger has given new meaning to our understanding of the genetics of obesity. New interest in gene expression as related to nutrition and advances in the field of macronutrients has made the latest nutrition research intriguing. Advanced Nutrition: Macronutrients adopts an integrated approach to the understanding of macronutrient nutrition. It provides scientific foundations of the current findings on energy balance, protein need, gene expression, and carbohydrate and lipid use, and maintains emphasis on the biochemical and physiological basis for nutrient need.
A groundbreaking, evidence-based text to the growing field of evolutionary medicine Evidence-Based Evolutionary Medicine offers a comprehensive review of the burgeoning field of evolutionary medicine and explores vital topics such as evolution, ecology, and aging as they relate to mainstream medicine. The text integrates Darwinian principles and evidence-based medicine in order to offer a clear picture of the underlying principles that reflect how and why organisms have evolved on a cellular level. The authors—noted authorities in their respective fields—address evolutionary medicine from a developmental cell-molecular perspective. They explore the first principles of physiology that explain the generation of existing tissues, organs, and organ systems. The text offers an understanding of the overall biology as a vertically integrated whole, from unicellular to multicellular organisms. In addition, it addresses clinical diagnostic and therapeutic approaches, both traditional and cell-homeostatic. This groundbreaking text: • Offers a much-needed, logical, and fundamental approach to biology and medicine • Provides a clear explanation of complex physiology and pathophysiology • Integrates topics like evolution, ecology and aging into mainstream medicine, making them more relevant • Contains the first evidence-based text on evolutionary medicine Written for medical and graduate students in biology, physiology, anatomy, endocrinology, reproductive biology, medicine, pathology, systems biology, this vital resource offers a unique text of both biology as an integrated whole with universal properties; and of medicine seeing the individual as a whole, not an inventory of parts and diseases.
This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C. elegans, bivalve molusc Mytilus and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five distinguished mitochondrial research teams from around the world, this volume will target a wide audience of physiologists, anatomists, cell, and developmental and evolutionary biologists, as well as physicians, veterinarians, livestock specialists and biomedical researchers.