The Annotated Hodgkin and Huxley Book

The Annotated Hodgkin and Huxley


  • Author : Indira M. Raman
  • Publisher : Princeton University Press
  • File Size : 10,8 Mb
  • Release Date : 2022-01-11
  • Genre: Science
  • Pages : 328
  • ISBN 10 : 9780691220659

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The first annotated edition of the scientific papers that created the foundation of modern neuroscience and physiology The origin of everything known about how neurons and muscles generate electrical signals can be traced back to five revolutionary papers, published in the Journal of Physiology in 1952 by Alan Hodgkin and Andrew Huxley. The principles they revealed remain cornerstones of the discipline, summarized in every introductory neuroscience and physiology course. Since that era, however, scientific practice, technology, and presentation have changed extensively. It is difficult for the modern reader to appreciate Hodgkin and Huxley’s rigorous scientific thought, elegant experimental design, ingenious analysis, and beautiful writing. This book provides the first annotated edition of these papers, offering essential background on everything, from terminology, equations, and electronics, to the greater historical and scientific context surrounding the work. The original journal pages are displayed opposite detailed notes explaining content, process, and background, with copies of the figures replotted according to modern conventions. Indispensable for scientists, teachers, and trainees alike, The Annotated Hodgkin and Huxley makes an essential body of knowledge—and an unparalleled approach to research—accessible to a new generation of readers. Reproduces the original articles paired with extensive annotations on facing pages Replots figures with modern conventions of data display Explains the development of the voltage clamp and the discovery of ionic currents and action potential generation, foundational to the study of neuroscience and physiology Summarizes the history of electrophysiology leading to Hodgkin and Huxley’s work Includes appendices on relevant concepts from mathematics, physics, electronics, chemical kinetics, and numerical methods

Foundations of Cellular Neurophysiology Book

Foundations of Cellular Neurophysiology


  • Author : Daniel Johnston
  • Publisher : MIT Press
  • File Size : 18,5 Mb
  • Release Date : 1994-11-02
  • Genre: Medical
  • Pages : 709
  • ISBN 10 : 9780262293495

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with simulations and illustrations by Richard Gray Problem solving is an indispensable part of learning a quantitative science such as neurophysiology. This text for graduate and advanced undergraduate students in neuroscience, physiology, biophysics, and computational neuroscience provides comprehensive, mathematically sophisticated descriptions of modern principles of cellular neurophysiology. It is the only neurophysiology text that gives detailed derivations of equations, worked examples, and homework problem sets (with complete answers). Developed from notes for the course that the authors have taught since 1983, Foundations of Cellular Neurophysiology covers cellular neurophysiology (also some material at the molecular and systems levels) from its physical and mathematical foundations in a way that is far more rigorous than other commonly used texts in this area.

The Synaptic Organization of the Brain Book

The Synaptic Organization of the Brain


  • Author : Gordon M. Shepherd
  • Publisher : Oxford University Press
  • File Size : 17,9 Mb
  • Release Date : 2004
  • Genre: Medical
  • Pages : 736
  • ISBN 10 : 9780195159561

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This is a thorough revision of the standard text on local circuits in the different regions of the brain. In this fifth edition, the results of the mouse and human genome projects are incorporated for the first time. Also for the first time, the reader is oriented to supporting neuroscience databases. Among the new advances covered are 2-photon confocal laser microscopy of dendrites and dendritic spines, biochemical analyses, and dual patch and multielectrode recordings, applied together with an increasing range of behavioral and gene-targeting methods.

MATLAB for Neuroscientists Book

MATLAB for Neuroscientists


  • Author : Pascal Wallisch
  • Publisher : Academic Press
  • File Size : 13,6 Mb
  • Release Date : 2014-01-09
  • Genre: Computers
  • Pages : 570
  • ISBN 10 : 9780123838377

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MATLAB for Neuroscientists serves as the only complete study manual and teaching resource for MATLAB, the globally accepted standard for scientific computing, in the neurosciences and psychology. This unique introduction can be used to learn the entire empirical and experimental process (including stimulus generation, experimental control, data collection, data analysis, modeling, and more), and the 2nd Edition continues to ensure that a wide variety of computational problems can be addressed in a single programming environment. This updated edition features additional material on the creation of visual stimuli, advanced psychophysics, analysis of LFP data, choice probabilities, synchrony, and advanced spectral analysis. Users at a variety of levels—advanced undergraduates, beginning graduate students, and researchers looking to modernize their skills—will learn to design and implement their own analytical tools, and gain the fluency required to meet the computational needs of neuroscience practitioners. The first complete volume on MATLAB focusing on neuroscience and psychology applications Problem-based approach with many examples from neuroscience and cognitive psychology using real data Illustrated in full color throughout Careful tutorial approach, by authors who are award-winning educators with strong teaching experience

Textbook of Physiology Book

Textbook of Physiology


  • Author : Harry D. Patton
  • Publisher : W.B. Saunders Company
  • File Size : 6,8 Mb
  • Release Date : 1989
  • Genre: Biophysics
  • Pages : 864
  • ISBN 10 : UOM:39015014473485

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Feedback Systems Book

Feedback Systems


  • Author : Karl Johan Åström
  • Publisher : Princeton University Press
  • File Size : 19,6 Mb
  • Release Date : 2021-02-02
  • Genre: Technology & Engineering
  • Pages : null
  • ISBN 10 : 9780691213477

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The essential introduction to the principles and applications of feedback systems—now fully revised and expanded This textbook covers the mathematics needed to model, analyze, and design feedback systems. Now more user-friendly than ever, this revised and expanded edition of Feedback Systems is a one-volume resource for students and researchers in mathematics and engineering. It has applications across a range of disciplines that utilize feedback in physical, biological, information, and economic systems. Karl Åström and Richard Murray use techniques from physics, computer science, and operations research to introduce control-oriented modeling. They begin with state space tools for analysis and design, including stability of solutions, Lyapunov functions, reachability, state feedback observability, and estimators. The matrix exponential plays a central role in the analysis of linear control systems, allowing a concise development of many of the key concepts for this class of models. Åström and Murray then develop and explain tools in the frequency domain, including transfer functions, Nyquist analysis, PID control, frequency domain design, and robustness. Features a new chapter on design principles and tools, illustrating the types of problems that can be solved using feedback Includes a new chapter on fundamental limits and new material on the Routh-Hurwitz criterion and root locus plots Provides exercises at the end of every chapter Comes with an electronic solutions manual An ideal textbook for undergraduate and graduate students Indispensable for researchers seeking a self-contained resource on control theory

The Annotated and Illustrated Double Helix Book
Score: 3.5
From 2 Ratings

The Annotated and Illustrated Double Helix


  • Author : James D. Watson
  • Publisher : Simon and Schuster
  • File Size : 19,5 Mb
  • Release Date : 2012-11-06
  • Genre: Science
  • Pages : 368
  • ISBN 10 : 9781476715513

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Published to mark the fiftieth anniversary of the Nobel Prize for Watson and Crick’s discovery of the structure of DNA, an annotated and illustrated edition of this classic book gives new insights into the personal relationships between James Watson, Frances Crick, Maurice Wilkins, and Rosalind Franklin, and the making of a scientific revolution.

The NEURON Book Book

The NEURON Book


  • Author : Nicholas T. Carnevale
  • Publisher : Cambridge University Press
  • File Size : 15,9 Mb
  • Release Date : 2006-01-12
  • Genre: Medical
  • Pages : null
  • ISBN 10 : 9781139447836

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The authoritative reference on NEURON, the simulation environment for modeling biological neurons and neural networks that enjoys wide use in the experimental and computational neuroscience communities. This book shows how to use NEURON to construct and apply empirically based models. Written primarily for neuroscience investigators, teachers, and students, it assumes no previous knowledge of computer programming or numerical methods. Readers with a background in the physical sciences or mathematics, who have some knowledge about brain cells and circuits and are interested in computational modeling, will also find it helpful. The NEURON Book covers material that ranges from the inner workings of this program, to practical considerations involved in specifying the anatomical and biophysical properties that are to be represented in models. It uses a problem-solving approach, with many working examples that readers can try for themselves.

A Century of Artists Books Book

A Century of Artists Books


  • Author : Riva Castleman
  • Publisher : ABRAMS
  • File Size : 16,9 Mb
  • Release Date : 1997-09
  • Genre: Uncategoriezed
  • Pages : 0
  • ISBN 10 : 0810961814

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Published to accompany the 1994 exhibition at The Museum of Modern Art, New York, this book constitutes the most extensive survey of modern illustrated books to be offered in many years. Work by artists from Pierre Bonnard to Barbara Kruger and writers from Guillaume Apollinarie to Susan Sontag. An importnt reference for collectors and connoisseurs. Includes notable works by Marc Chagall, Henri Matisse, and Pablo Picasso.

Ion Channels in Health and Sickness Book

Ion Channels in Health and Sickness


  • Author : Fatima Shad Kaneez
  • Publisher : BoD – Books on Demand
  • File Size : 10,8 Mb
  • Release Date : 2018-10-10
  • Genre: Science
  • Pages : 204
  • ISBN 10 : 9781789842272

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Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.

Genome Chaos Book

Genome Chaos


  • Author : Henry H. Heng
  • Publisher : Academic Press
  • File Size : 5,5 Mb
  • Release Date : 2019-05-25
  • Genre: Medical
  • Pages : 556
  • ISBN 10 : 9780128136362

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Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. Bridges basic research and clinical application and provides a foundation for re-examining the results of large-scale omics studies and advancing molecular medicine Gathers the most pressing questions in genomic and cytogenomic research Offers alternative explanations to timely puzzles in the field Contains eight evidence-based chapters that discuss 4d-genomics, genes and genomes as distinct biological entities, genome chaos and macro-cellular evolution, evolutionary cytogenetics and cancer, chromosomal coding and fuzzy inheritance, and more

Waves in Neural Media Book

Waves in Neural Media


  • Author : Paul C. Bressloff
  • Publisher : Springer Science & Business Media
  • File Size : 14,7 Mb
  • Release Date : 2013-10-17
  • Genre: Mathematics
  • Pages : 436
  • ISBN 10 : 9781461488668

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​Waves in Neural Media: From Single Neurons to Neural Fields surveys mathematical models of traveling waves in the brain, ranging from intracellular waves in single neurons to waves of activity in large-scale brain networks. The work provides a pedagogical account of analytical methods for finding traveling wave solutions of the variety of nonlinear differential equations that arise in such models. These include regular and singular perturbation methods, weakly nonlinear analysis, Evans functions and wave stability, homogenization theory and averaging, and stochastic processes. Also covered in the text are exact methods of solution where applicable. Historically speaking, the propagation of action potentials has inspired new mathematics, particularly with regard to the PDE theory of waves in excitable media. More recently, continuum neural field models of large-scale brain networks have generated a new set of interesting mathematical questions with regard to the solution of nonlocal integro-differential equations. Advanced graduates, postdoctoral researchers and faculty working in mathematical biology, theoretical neuroscience, or applied nonlinear dynamics will find this book to be a valuable resource. The main prerequisites are an introductory graduate course on ordinary differential equations or partial differential equations, making this an accessible and unique contribution to the field of mathematical biology.

Hard to Break Book

Hard to Break


  • Author : Russell A. Poldrack
  • Publisher : Princeton University Press
  • File Size : 12,9 Mb
  • Release Date : 2021-05-04
  • Genre: Psychology
  • Pages : 230
  • ISBN 10 : 9780691194325

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"Well-publicized research in psychology tells us that over half of our attempts to change habitual behavior fail within one year. Even without reading the research, most of us will intuitively sense the truth in this, as we have all tried and failed to rid ourselves of one bad habit or another. The human story of habits and the difficulty of change has been told in many books--most of which will make only a quick reference to dopamine or the 'lizard brain' before moving on to practical tips and tricks for behavior change. In contrast, [this book] will tell the brain's story about why behavior is so hard to change"--

The Self Assembling Brain Book

The Self Assembling Brain


  • Author : Peter Robin Hiesinger
  • Publisher : Princeton University Press
  • File Size : 16,9 Mb
  • Release Date : 2021-05-04
  • Genre: Computers
  • Pages : 382
  • ISBN 10 : 9780691181226

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"In this book, Peter Robin Hiesinger explores historical and contemporary attempts to understand the information needed to make biological and artificial neural networks. Developmental neurobiologists and computer scientists with an interest in artificial intelligence - driven by the promise and resources of biomedical research on the one hand, and by the promise and advances of computer technology on the other - are trying to understand the fundamental principles that guide the generation of an intelligent system. Yet, though researchers in these disciplines share a common interest, their perspectives and approaches are often quite different. The book makes the case that "the information problem" underlies both fields, driving the questions that are driving forward the frontiers, and aims to encourage cross-disciplinary communication and understanding, to help both fields make progress. The questions that challenge researchers in these fields include the following. How does genetic information unfold during the years-long process of human brain development, and can this be a short-cut to create human-level artificial intelligence? Is the biological brain just messy hardware that can be improved upon by running learning algorithms in computers? Can artificial intelligence bypass evolutionary programming of "grown" networks? These questions are tightly linked, and answering them requires an understanding of how information unfolds algorithmically to generate functional neural networks. Via a series of closely linked "discussions" (fictional dialogues between researchers in different disciplines) and pedagogical "seminars," the author explores the different challenges facing researchers working on neural networks, their different perspectives and approaches, as well as the common ground and understanding to be found amongst those sharing an interest in the development of biological brains and artificial intelligent systems"--

The Double Helix Book
Score: 3.5
From 20 Ratings

The Double Helix


  • Author : James D. Watson
  • Publisher : Simon and Schuster
  • File Size : 13,5 Mb
  • Release Date : 2011-08-16
  • Genre: Science
  • Pages : 256
  • ISBN 10 : 9780743219174

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The classic personal account of Watson and Crick’s groundbreaking discovery of the structure of DNA, now with an introduction by Sylvia Nasar, author of A Beautiful Mind. By identifying the structure of DNA, the molecule of life, Francis Crick and James Watson revolutionized biochemistry and won themselves a Nobel Prize. At the time, Watson was only twenty-four, a young scientist hungry to make his mark. His uncompromisingly honest account of the heady days of their thrilling sprint against other world-class researchers to solve one of science’s greatest mysteries gives a dazzlingly clear picture of a world of brilliant scientists with great gifts, very human ambitions, and bitter rivalries. With humility unspoiled by false modesty, Watson relates his and Crick’s desperate efforts to beat Linus Pauling to the Holy Grail of life sciences, the identification of the basic building block of life. Never has a scientist been so truthful in capturing in words the flavor of his work.