Spontaneous Pathology Of The Laboratory Non Human Primate Pdf Download

Spontaneous Pathology of the Laboratory Non human Primate

Author : Alys E. Bradley
Publisher : Academic Press
File Size : 16,6 Mb
Release Date : 2023-09-01
Genre: Science
Pages : 0
ISBN 10 : 9780128130896

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Spontaneous Pathology of the Laboratory Non-human Primate serves as a "go to" resource for all pathologists working on primates in safety assessment studies. In addition, it helps diagnostic veterinary pathologists rule out spontaneous non-clinical disease pathologies when assigning cause of death to species in zoological collections. Primate species included are rhesus, cynomolgus macaques and marmosets. Multi-authored chapters are arranged by organ system, thus providing the necessary information for continued research. Pathologists often face a lack of suitable reference materials or historical data to determine if pathologic changes they are observing in monkeys are spontaneous or a consequence of other treatments or factors. Contains color illustrations that depict the most common lesions to augment descriptions Covers descriptions that are compliant with the International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) guidelines set forth by the Society of Toxicologic Pathology (STP) Provides pathologists with common terms that are compliant with the FDA’s Standard for Exchange of Nonclinical Data (SEND) guidelines

Nonhuman Primates in Biomedical Research

Author : Christian R. Abee
Publisher : Academic Press
File Size : 13,8 Mb
Release Date : 2012-06-07
Genre: Medical
Pages : 868
ISBN 10 : 9780123978387

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The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in bioledical research Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information Includes four color images throughout

Nonhuman Primates

Author : Thomas C. Jones
Publisher : Springer Science & Business Media
File Size : 14,9 Mb
Release Date : 2012-12-06
Genre: Medical
Pages : 248
ISBN 10 : 9783642849244

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The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmonize toxicologic testing, to advance a more uniform interpreta tion of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scientists. The M on ographs on the Pathology of Laboratory Animals are de signed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others con cerned with evaluating toxicity and carcinogenicity stud ies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors - strengthens our expectations that understanding and cooperation will be improved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book on nonhuman primate pathology is the 12th volume of a set of monographs prepared under the sponsorship of the International Life Sciences Institute (ILSI).

Primates

Author : Kurt Benirschke
Publisher : Springer Science & Business Media
File Size : 5,8 Mb
Release Date : 2012-12-06
Genre: Science
Pages : 1044
ISBN 10 : 9781461249184

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This conference represents the first time in my life when I felt it was a misfor tune, rather than a major cause of my happiness, that I do conservation work in New Guinea. Yes, it is true that New Guinea is a fascinating microcosm, it has fascinating birds and people, and it has large expanses of undisturbed rainforest. In the course of my work there, helping the Indonesian government and World Wildlife Fund set up a comprehensive national park system, I have been able to study animals in areas without any human population. But New Guinea has one serious drawback: it has no primates, except for humans. Thus, I come to this conference on primate conservation as an underprivileged and emotionally deprived observer, rather than as an involved participant. Nevertheless, it is easy for anyone to become interested in primate conserva tion. The public cares about primates. More specifically, to state things more realistically, many people care some of the time about some primates. Primates are rivaled only by birds, pandas, and the big cats in their public appeal. For some other groups of animals, the best we can say is that few people care about them, infrequently. For most groups of animals, no one cares about them, ever.

The Baboon in Biomedical Research

Author : John L. VandeBerg
Publisher : Springer Science & Business Media
File Size : 12,5 Mb
Release Date : 2009-06-04
Genre: Science
Pages : 392
ISBN 10 : 0387759913

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Nonhuman primates have played critical roles in biomedical research, and they are among the few animals whose use in research continues to increase. The scienti?c value of nonhuman primates derives from their close phylogenetic proximity to man and their consequent anatomic, physiologic, and genetic similarities to man. Only nonhuman primates can provide adequate models for many complex physiological and disease processes of humans. The baboon is a relative newcomer to the repertoire of nonhuman primates used in biomedical research. However, in less than 50 years since its ?rst use in the U. S. , it has become one of the most popular laboratory primate species. It is larger than the other widely used monkey species, making it advantageous for many types of experiments and technological developments. It is extraordinarily hardy and highly fecund in captivity. It closely resembles humans in a variety of physiological and disease processes, such as cholesterol metabolism, early stages of atherosclerosis, and alcoholic liver disease. Its chromosomes closely resemble those of humans, and many genes of the two species lie in the same chromosomal order. Among all primates, baboons are the most widely used models for the genetics of susceptibility to complex diseases and they are the ?rst nonhuman primate for which a framework genetic linkage map was established. In addition, the baboon genome is currently being sequenced, and as a result the utility of this species for biomedical research will be dramatically increased.

Nonhuman Primates I

Author : Thomas C. Jones
Publisher : Springer Science & Business Media
File Size : 10,8 Mb
Release Date : 2012-12-06
Genre: Medical
Pages : 221
ISBN 10 : 9783642849060

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The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmonize toxicologic testing, to advance a more uniform interpreta tion of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scientists. The Mo nographs on the Pathology of Laboratory Animals are de signed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others con cerned with evaluating toxicity and carcinogenicity stu dies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors -strengthens our expectations that understanding and cooperation will be improved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book, on Nonhuman Primates, is the eleventh volume of a set pre pared under the sponsorship of the International Life Sciences Institute (ILSI).

Background Lesions in Laboratory Animals E Book

Author : Elizabeth Fiona McInnes
Publisher : Elsevier Health Sciences
File Size : 8,7 Mb
Release Date : 2011-10-24
Genre: Medical
Pages : 256
ISBN 10 : 9780702049248

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Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. It gives clear descriptions and illustrations of the majority of background lesions likely to be encountered. Many of the lesions covered are unusual and can be mistaken for treatment-related findings in preclinical toxicity studies. The Atlas has been prepared with contributions from experienced toxicological pathologists who are specialists in each of the laboratory animal species covered and who have published extensively in these areas. over 600 high-definition, top-quality color photographs of background lesions found in rats, mice, dogs, minipigs, non-human primates, hamsters, guinea pigs and rabbits a separate chapter on lesions in the reproductive systems of all laboratory animals written by Dr Dianne Creasy, a world expert on testicular lesions in laboratory animals a chapter on common artifacts that may be observed in histological glass slides extensive references to each lesion described aging lesions encountered in all laboratory animal species, particularly in rats in mice which are used for carcinogenicity studies

Spontaneous Pathology of the Laboratory Rabbit

Author : Alys Bradley
Publisher : Academic Press
File Size : 6,5 Mb
Release Date : 2023-04-15
Genre: Science
Pages : 575
ISBN 10 : 0128225289

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Spontaneous Pathology of the Laboratory Rabbit serves as a "go to” text for all pathologists working on laboratory rabbits in safety assessment studies. The book helps diagnostic veterinary pathologists rule out spontaneous non-clinical disease pathology when assigning cause of death to these animals which are also kept as domestic pets. The book provides a comprehensive text on the spontaneous pathology seen in common laboratory rabbit strains. This is the first book collating information on all organ systems in these strains. Consist of multi-author chapters arranged by organ systems Presents color illustrations that depict the most common lesions to augment the descriptions Provides pathologists with common terms that are compliant with the FDA's Standard for Exchange of Nonclinical Data (SEND) guidelines Gives references for recommended tissue trimming planes

Primate Models of Children s Health and Developmental Disabilities

Author : Thomas Burbacher
Publisher : Academic Press
File Size : 16,7 Mb
Release Date : 2011-10-10
Genre: Medical
Pages : 472
ISBN 10 : 0080554067

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The rate of neurodevelopmental disabilities, including autism, mental retardation, hearing loss and attention deficit hyperactivity disorder is rising in the United States. Although estimates of the prevalence of these disorders vary, figures from the CDC indicate that 4% of all school age children are developmentally disabled. During infancy, many important milestones in behavioral development are shared between human and nonhuman primates. Learning more about the causes of abnormal development in monkeys has provided important insights into the mechanisms underlying neurodevelopmental disabilities in human infants. This book documents the latest research not commonly found in other references, and provides a comprehensive look at the results from decades of work with nonhuman primates as it relates to child development and disability. Includes hot topics such as early chemical exposures, immunological influences on development, low birth weight, endocrine disrupters, pediatric AIDS, origin of childhood psychopathologies and assisted reproductive technology Represents the significant body of work accumulated since funding for research on developmental disabilities has increased substantially in recent years

Pathology for Toxicologists

Author : Elizabeth McInnes
Publisher : John Wiley & Sons
File Size : 9,6 Mb
Release Date : 2017-03-16
Genre: Science
Pages : 216
ISBN 10 : 9781118755310

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Non-pathologists, such as toxicologists and study personnel, can find it difficult to understand the data they receive from pathologists. Toxicological pathologists write long, detailed and highly technical reports. Study personnel are under daily pressure to decide whether lesions described in pathology reports are treatment-related and thus important to the pharmaceutical company or whether the lesions are background changes and thus of little significance. Written by experienced toxicological pathologists, Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel serves to bridge the gap in the understanding of pathology data, enabling non-pathologists to more easily comprehend pathology reports, better integrate pathology data into final study reports and ask pathologists relevant questions about the test compound. This succinct, fully referenced, full colour book is suitable for toxicologists at all stages of their training or career who want to know more about the pathology encountered in laboratory animals used in safety studies. Key features include important chapters on spontaneous and target organ lesions in rats, mice, non-human primates, mini pigs, rabbits and beagle dogs as well as information on general pathology, macroscopic target organ lesions, ancillary pathology techniques, haematology, biochemistry and adversity. Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel includes: Colour diagrams explaining how lesions are caused by either external compounds or spontaneously The anatomic variations and background lesions of laboratory animals Advice on sampling tissues, necropsy, ancillary pathology techniques and recording data A chapter on the haematology and biochemistry of laboratory animals Full colour photographs of common macroscopic lesions encountered in laboratory animals A comprehensive glossary

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

Author : Joerg Bluemel
Publisher : Academic Press
File Size : 8,9 Mb
Release Date : 2015-03-13
Genre: Medical
Pages : 716
ISBN 10 : 9780124171466

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The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes

Haschek and Rousseaux s Handbook of Toxicologic Pathology

Author : Wanda M. Haschek
Publisher : Academic Press
File Size : 6,7 Mb
Release Date : 2021-10-20
Genre: Medical
Pages : 1152
ISBN 10 : 9780128218297

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Haschek and Rousseaux's Handbook of Toxicologic Pathology: Volume 1: Principles and Practice of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Volume 1 of the Fourth Edition covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Completely revised with a number of new chapters, Volume 1 of the Handbook of Toxicologic Pathology is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Provides new chapters on digital pathology, juvenile pathology, in vitro/in vivo correlation, big data technologies and in-depth discussion of timely topics in the area of toxicologic pathology Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Nonhuman Primates in Biomedical Research

Author : Christian R. Abee
Publisher : Academic Press
File Size : 11,7 Mb
Release Date : 2012-03-29
Genre: Medical
Pages : 868
ISBN 10 : 9780123813664

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Annotation A comprehensive review of the use of nonhuman primates in biomedical research. This volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases.

Nonhuman Primates in Biomedical Research

Author : Anonim
Publisher : Elsevier
File Size : 20,9 Mb
Release Date : 1998-07-24
Genre: Medical
Pages : 512
ISBN 10 : 0080537634

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This volume and its companion Nonhuman Primates in Biomedical Research: Biology and Management represent the most comprehensive publications of their type on nonhuman primates. This volume addresses the diseases of nonhuman primates with an emphasis on the etiological factors, clinical signs, diagnostic pathology, therapy, and management. Its companion volume serves as a general reference for those who provide care for these animals and for those who use them in biomedical research.

Pathology of Laboratory Swine

Author : Kris Helke
Publisher : Academic Press
File Size : 9,8 Mb
Release Date : 2023-06-01
Genre: Science
Pages : 0
ISBN 10 : 0128231165

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Pathology of Laboratory Swine is a comprehensive text describing the spontaneous pathology seen in the common laboratory pig strains. This is the first book collating information on all organ systems in these strains. Pigs are now used in greater numbers in contract research organizations as well as in the pharmaceutical industry. They provide significant advantages over dogs due to their greater tolerance of non-steroidal anti-inflammatory drugs, antihypertensive agents and sympathicomimetic drugs. Pigs are easier to house, handle, dose and sample than non-human primates and there are no zoonoses (in contrast to non-human primates). There are fewer ethical or conservation concerns, sexually mature animals are readily available and global transportation of pigs is easier. Pathology of Laboratory Swine serves as a "go to” text for all pathologists working on laboratory pigs in safety assessment studies, and to help diagnostic veterinary pathologists rule out spontaneous non-clinical disease pathology when assigning cause of death to these animals which are also kept as domestic pets.