Pyrazole Based Drug Discovery Book

Pyrazole Based Drug Discovery


  • Author : Nachiket S. Dighe
  • Publisher : Elsevier
  • Release Date : 2021-06-15
  • Genre: Science
  • Pages : 370
  • ISBN 10 : 0128241403
  • Total Read : 73
  • File Size : 20,8 Mb

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Pyrazole Based Drug Discovery Summary:

Pyrazole-Based Drug Discovery outlines the complexities of the pyrazole scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Designed as a guide for both experts and students working in this and related areas, this volume will facilitate the continued design and development of novel pharmaceuticals based on pyrazole and its derivatives. Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers. Pyrazole is a novel heterocycle with anti-fungal, antimicrobial, anti-tubercular, and antipsychotic pharmacological activities, proving to be a promising agent for medicinal chemists to synthesize various new chemical entities with desired biological activities. This book is ideal for researchers working in organic and medicinal chemistry both in academia and industry. Explores this extremely important heterocycle in a high level of detail Describes synthesis methods for current drugs based on pyrazole scaffolds Gives drug designers all the key knowledge required to develop new drugs utilizing pyrazole Provides pharmacologists a solid overview of the chemical background of existing pyrazole-based drugs

Pyrazole  Preparation and Uses Book

Pyrazole Preparation and Uses


  • Author : Dilipkumar Pal
  • Publisher : Nova Science Publishers
  • Release Date : 2020-08-11
  • Genre: Uncategoriezed
  • Pages : 563
  • ISBN 10 : 1536182508
  • Total Read : 81
  • File Size : 17,6 Mb

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Pyrazole Preparation and Uses Summary:

This book has comprehensively reviewed the latest information on pyrazoles, their preparations and uses. It provides extended ideas on pyrazole and its derivatives including their synthesis, chemistry, structure activity relationship (SAR) and therapeutic applications. The health promoting properties of these pyrazoles are discussed in this book with different therapeutic applications of pyrazole scaffold. Topics related to pyrazole and its analogues as potential anticancer, anti-angiogenesis, antiviral, antioxidative, anti-convulsive, anthelmintic, anti-inflammatory, antidiabetic agents are described in this book in detail. Furthermore, current status and future prospects of pyrazole moiety in drug discovery, importance of it in plant systems, its relevance in neurological drug discovery, its potency as herbicidal and antimicrobial agents have been enumerated through different chapters. In a summary, this book is a valuable resource for research scholars, academics, students, industrialists and subject experts working in the multidisciplinary fields like medicinal chemistry, synthetic chemistry, biochemistry, pharmacology, natural product chemistry and other related areas in the field of pyrazole derivatives drug discovery and research.

Privileged Scaffolds in Medicinal Chemistry Book

Privileged Scaffolds in Medicinal Chemistry


  • Author : Stefan Bräse
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-11-20
  • Genre: Medical
  • Pages : 486
  • ISBN 10 : 9781782620303
  • Total Read : 74
  • File Size : 19,8 Mb

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Privileged Scaffolds in Medicinal Chemistry Summary:

This book addresses the various classes of privileged scaffolds and covers the history of their discovery and use.

Structure based Drug Discovery Book

Structure based Drug Discovery


  • Author : Harren Jhoti
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-05-24
  • Genre: Science
  • Pages : 250
  • ISBN 10 : 9781402044076
  • Total Read : 92
  • File Size : 19,5 Mb

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Structure based Drug Discovery Summary:

This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments in technologies that can be used to obtain the 3-D structures. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions.

Heterocyclic Chemistry in Drug Discovery Book
Score: 5
From 1 Ratings

Heterocyclic Chemistry in Drug Discovery


  • Author : Jie Jack Li
  • Publisher : John Wiley & Sons
  • Release Date : 2013-04-26
  • Genre: Science
  • Pages : 720
  • ISBN 10 : 9781118354438
  • Total Read : 90
  • File Size : 8,6 Mb

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Heterocyclic Chemistry in Drug Discovery Summary:

Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.

Privileged Structures in Drug Discovery Book

Privileged Structures in Drug Discovery


  • Author : Larry Yet
  • Publisher : John Wiley & Sons
  • Release Date : 2018-03-07
  • Genre: Medical
  • Pages : 560
  • ISBN 10 : 9781118686355
  • Total Read : 78
  • File Size : 6,6 Mb

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Privileged Structures in Drug Discovery Summary:

A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field. The book describes the up-to-date and state-of-the-art methods of organic synthesis that describe the use of privileged structures that are of most interest. Chapters included information on benzodiazepines, 1,4-dihydropyridines, biaryls, 4-(hetero)arylpiperidines, spiropiperidines, 2-aminopyrimidines, 2-aminothiazoles, 2-(hetero)arylindoles, tetrahydroisoquinolines, 2,2-dimethylbenzopyrans, hydroxamates, and bicyclic pyridines containing ring-junction nitrogen as privileged scaffolds in medicinal chemistry. Numerous, illustrative case studies document the current use of the privileged structures in the discovery of drugs. This important volume: Describes the drug compounds that have successfully made it to the marketplace and the chemistry associated with them Offers the experience from an author who has worked in many therapeutic areas of medicinal chemistry Details many of the recent developments in organic chemistry that prepare target molecules Includes a wealth of medicinal chemistry case studies that clearly illustrate the use of privileged structures Designed for use by industrial medicinal chemists and process chemists, academic organic and medicinal chemists, as well as chemistry students and faculty, Privileged Structures in Drug Discovery offers a current guide to organic syn

Synthetic Methods in Drug Discovery Book

Synthetic Methods in Drug Discovery


  • Author : David C. Blakemore
  • Publisher : Royal Society of Chemistry
  • Release Date : 2016
  • Genre: Drug development
  • Pages : 474
  • ISBN 10 : 9781849738033
  • Total Read : 81
  • File Size : 11,7 Mb

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Synthetic Methods in Drug Discovery Summary:

The number of available synthetic methods can be overwhelming. In order to create novel motifs and templates which confer new and potentially valuable drug-like properties, it is important to know which synthetic methodologies will give the best results. Similarly, which methodologies are used to progress potential drug candidates from leads through the development process? What are the current industrial research problems and how can they be resolved in an industrial setting? This book highlights key methods that have real impact in drug discovery and facilitate delivery of drug molecules. Synthetic Methods in Drug Discovery Volume 1 focuses on the hugely important area of transition metal mediated methods used in industry. Current methods of importance such as the Suzuki-Miyaura coupling, Buchwald-Hartwig couplings and CH activation are discussed. In addition, exciting emerging areas such as decarboxylative coupling, and the uses of iron and nickel in coupling reactions are also covered. This book provides both academic and industrial perspectives on some key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reaction types are conveniently framed in the context of their value to industry and the challenges and limitations of methodologies are discussed with relevant illustrative examples. Edited and authored by leading scientists from both academia and industry, this book will be a valuable reference for all chemists involved in drug discovery as well as postgraduate students in medicinal chemistry.

Drug Discovery for Leishmaniasis Book

Drug Discovery for Leishmaniasis


  • Author : Carmen Gil
  • Publisher : Royal Society of Chemistry
  • Release Date : 2017-10-26
  • Genre: Science
  • Pages : 402
  • ISBN 10 : 9781788012584
  • Total Read : 91
  • File Size : 15,6 Mb

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Drug Discovery for Leishmaniasis Summary:

For human health, leishmaniasis is among the most important protozoan diseases, superseded only by malaria. Globally, 10 to 12 million people are infected with 1.5 million new cases every year. The development of cheaper new drugs is urgently needed for this neglected disease that is developing resistance to current treatments. Chemotherapy remains the only treatment option for the bulk of patients. However, this is largely unaffordable for most. In the past three years numerous advances in drug discovery have been made for treating this disease by exploiting diverging metabolic pathways between the Leishmania enzymes and their hosts, using nanotechnology to target the immune cell phagolysosomes where Leishmania resides. Drug Discovery for Leishmaniasis aims to provide a perspective of the current treatments and their challenges, blended with the emerging strategies and methodologies that will drive new target appraisals and drug developments, as well as addressing the molecular basis of resistance in Leishmania. Recent studies have shown that leishmaniasis affects some of the poorest people in the world, with 95% of fatal cases occurring in only 6 countries. With the WHO goal of eliminating this public health problem in the South-east Asia Region by 2020, this book will be important for anyone who is interested in neglected tropical diseases.