Polymyxin Antibiotics

Polymyxin Antibiotics

• Author : Jian Li (Pharmacologist)
• Publisher : Unknown
• File Size : 13,8 Mb
• Release Date : 2019
• Genre: Antibiotics
• Pages : null
• ISBN 10 : 3030163725

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It is our wish that readers discover the importance of polymyxin structure in relation to the mechanisms of activity, resistance and toxicity. We emphasized that reliable analytic methods for polymyxins are critical when investigating their pharmacokinetics (PK) and pharmacodynamics (PD). The complicated dose definitions and different pharmacopoeial standards have already compromised the safe use of polymyxins in patients. Therefore, informed by the latest pharmacological information, scientifically-based dosing recommendations have been proposed for intravenous polymyxins. Considering the PK/PD limitations and potential development of resistance, polymyxin combinations are encouraged; however, the current literature has not shown definite microbiological benefits, possibly because most clinical studies to date overlooked key PK/PD principles. Nephrotoxicity is the major dose-limiting factor and it is imperative to elucidate the mechanisms and develop novel approaches to minimize polymyxin-associated toxicities. In addition, the anti-endotoxin effect of polymyxins supports their clinical use to treat Gram-negative sepsis. Fortunately, the discovery of new-generation polymyxins with wider therapeutic windows has benefited from the latest achievements in polymyxin research.

Polymyxin Antibiotics From Laboratory Bench to Bedside

• Author : Jian Li
• Publisher : Springer
• File Size : 20,9 Mb
• Release Date : 2019-07-30
• Genre: Science
• Pages : 366
• ISBN 10 : 9783030163730

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This volume is the first-ever complete treatise on polymyxins and presents the most comprehensive and up-to-date reviews of all major research and clinical topics from chemistry, microbiology, pharmacology, clinical use, to drug discovery. All chapters were written by internationally leading researchers and clinicians in the field. It is our wish that readers discover the importance of polymyxin structure in relation to the mechanisms of activity, resistance and toxicity. We emphasized that reliable analytic methods for polymyxins are critical when investigating their pharmacokinetics (PK) and pharmacodynamics (PD). The complicated dose definitions and different pharmacopoeial standards have already compromised the safe use of polymyxins in patients. Therefore, informed by the latest pharmacological information, scientifically-based dosing recommendations have been proposed for intravenous polymyxins. Considering the PK/PD limitations and potential development of resistance, polymyxin combinations are encouraged; however, the current literature has not shown definite microbiological benefits, possibly because most clinical studies to date overlooked key PK/PD principles. Nephrotoxicity is the major dose-limiting factor and it is imperative to elucidate the mechanisms and develop novel approaches to minimize polymyxin-associated toxicities. In addition, the anti-endotoxin effect of polymyxins supports their clinical use to treat Gram-negative sepsis. Fortunately, the discovery of new-generation polymyxins with wider therapeutic windows has benefited from the latest achievements in polymyxin research. This book provides extensive pharmacological information on polymyxins to infectious diseases clinicians, pharmacists, clinical microbiologists, antimicrobial pharmacologists, and pharmaceutical scientists, and is an essential read for those who aim to develop novel polymyxins and improve their clinical use as a last-line defense against Gram-negative ‘superbugs’.

Polymyxin Antibiotics Advances in Research and Application 2012 Edition

• Author : Anonim
• Publisher : ScholarlyEditions
• File Size : 13,5 Mb
• Release Date : 2012-12-26
• Genre: Medical
• Pages : 19
• ISBN 10 : 9781481636612

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Polymyxin Antibiotics—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Polymyxin Antibiotics in a compact format. The editors have built Polymyxin Antibiotics—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Polymyxin Antibiotics in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Polymyxin Antibiotics—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Polymyxin Antibiotics Advances in Research and Application 2011 Edition

• Author : Anonim
• Publisher : ScholarlyEditions
• File Size : 7,8 Mb
• Release Date : 2012-01-09
• Genre: Medical
• Pages : 19
• ISBN 10 : 9781464957253

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Polymyxin Antibiotics: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Polymyxin Antibiotics in a compact format. The editors have built Polymyxin Antibiotics: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Polymyxin Antibiotics in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Polymyxin Antibiotics: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Antimicrobial Therapy in Veterinary Medicine

• Author : Steeve Giguère
• Publisher : John Wiley & Sons
• File Size : 15,6 Mb
• Release Date : 2013-07-25
• Genre: Medical
• Pages : 704
• ISBN 10 : 9781118675076

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The Fifth Edition of Antimicrobial Therapy in Veterinary Medicine, the most comprehensive reference available on veterinary antimicrobial drug use, has been thoroughly revised and updated to reflect the rapid advancements in the field of antimicrobial therapy. Encompassing all aspects of antimicrobial drug use in animals, the book provides detailed coverage of virtually all types of antimicrobials relevant to animal health. Now with a new chapter on antimicrobial therapy in zoo animals, Antimicrobial Therapy in Veterinary Medicine offers a wealth of invaluable information for appropriately prescribing antimicrobial therapies and shaping public policy. Divided into four sections covering general principles of antimicrobial therapy, classes of antimicrobial agents, special considerations, and antimicrobial drug use in multiple animal species, the text is enhanced by tables, diagrams, and photos. Antimicrobial Therapy in Veterinary Medicine is an essential resource for anyone concerned with the appropriate use of antimicrobial drugs, including veterinary practitioners, students, public health veterinarians, and industry and research scientists.

Antibiotics

• Author : David Gottlieb
• Publisher : Springer
• File Size : 9,6 Mb
• Release Date : 2013-11-27
• Genre: Medical
• Pages : 785
• ISBN 10 : 9783662384398

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Polymyxin Antibiotics Advances in Research and Application 2011 Edition

• Author : Anonim
• Publisher : ScholarlyEditions
• File Size : 6,7 Mb
• Release Date : 2012-01-09
• Genre: Medical
• Pages : 19
• ISBN 10 : 9781464957246

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Polymyxin Antibiotics: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Polymyxin Antibiotics in a compact format. The editors have built Polymyxin Antibiotics: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Polymyxin Antibiotics in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Polymyxin Antibiotics: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

The Antimicrobial Drugs

• Author : Eric M. Scholar
• Publisher : Oxford University Press, USA
• File Size : 14,6 Mb
• Release Date : 2000
• Genre: Anti-infective agents
• Pages : 632
• ISBN 10 : 0195125282

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This is a thorough updating of a classic text that has been published in three editions since Pratt's Chemotherapy of Infection (OUP, 1973). Its treatment of the mechanisms of action, pharmacology and adverse effects of the drugs used to treat bacterial, fungal, parasitic and viral infectionshas been greatly expanded, and this edition includes two completely new chapters on the fluoroquinolones and the drugs used to treat AIDS. the frugs used to treat AIDS.

Antibiotic Essentials 2010

• Author : Burke A. Cunha
• Publisher : Jones & Bartlett Publishers
• File Size : 10,8 Mb
• Release Date : 2010-03-23
• Genre: Medical
• Pages : 748
• ISBN 10 : 9780763792152

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Completely revised and updated, Antibiotic Essentials 2010 is a concise, practical, and authoritative guide to the treatment and prevention of infectious diseases commonly encountered in adults. It covers 542 clinical infectious disease syndromes, HIV infection, 134 detailed drug summaries, pediatric infectious diseases, and a chest x-ray atlas. Key topics include:Empiric Therapy Based on Clinical Syndrome Initial Therapy Based on Isolates Pending Susceptibility Testing HIV Infection Fungi, Parasites, Unusual Organisms Antibiotic Prophylaxis and Immunizations Drug Summaries

Optimizing Polymyxin Antibiotics Using Combination Therapy and Mechanism based Models

• Author : Neang S. Ly
• Publisher : Unknown
• File Size : 12,6 Mb
• Release Date : 2014
• Genre: Uncategoriezed
• Pages : 443
• ISBN 10 : OCLC:961274163

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The emergence of multidrug-resistant (MDR) Gram-negative 'superbugs' coupled with a rapid decline in the development of new antibiotics has led to a serious, global health crisis. Polymyxin antibiotics, which include polymyxin E (colistin) and polymyxin B, were introduced over 50 years ago and were seldom used due to nephrotoxicity. However, recently, the polymyxins have re-emerged in the clinic as an antibiotic of last-resort. There are increasing reports of polymyxin resistance and failure during polymyxin monotherapy. While polymyxin based combination therapies are a promising alternative, there are significant gaps regarding the optimal use of such combinations. The primary goal of this dissertation is to rationally optimize polymyxin combination therapy based on pharmacokinetic/pharmacodynamic (PK/PD) principles. Menchanism-based (PK/PD) models (MBMs) were employed to evaluate mechanisms of antibiotic synergy. A secondary goal is to define the mechanisms of polymyxin tolerance and resistance utilizing genetically modified knockout strains and to develop MBMs that quantify the impact of bacterial regulatory systems including quorum sensing mechanisms on antibiotic PD.

Dictionary of Antibiotics Related Substances

• Author : Barrie W. Bycroft
• Publisher : CRC Press
• File Size : 9,7 Mb
• Release Date : 1987-12-17
• Genre: Science
• Pages : 1008
• ISBN 10 : 0412254506

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Cumulated Index Medicus

• Author : Anonim
• Publisher : Unknown
• File Size : 14,9 Mb
• Release Date : 1991
• Genre: Medicine
• Pages : null
• ISBN 10 : OSU:32436010178778

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Antibiotic Policies

• Author : Ian M. Gould
• Publisher : Springer Science & Business Media
• File Size : 15,6 Mb
• Release Date : 2011-09-25
• Genre: Medical
• Pages : 209
• ISBN 10 : 1441917349

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The first book was on "Theory and Practice" of antibiotic stewardship in its broadest sense -the how to do it and the do's and don’ts. The second, on "Controlling resistance" was very much on the relationships between use and resistance and beginning to home in on the hospital as the main generator of resistance, but mainly looking at it from a disease/clinical perspective. The last 3 chapters on MRSA, ended where the 3rd book will take off. "Controlling HAI " will concentrate on specific MDR organisms highlighting their roles in the current pandemic of HAI and emphasizing that the big issue is not so much infection control but antibiotic control, in the same way that antibiotic over-reliance/ over-use has caused the problem in the first place. Up 'till now the emphasis for controlling MRSA, C diff and all the other MDROs has very much been on IC, which clearly isn't working. This book will gather all the evidence for the increasingly popular view that much more must be done in the area of antibiotic policies/ stewardship, especially when we are in danger of a "post antibiotic" era, due to a real shortage of new agents in the pipeline.

Antibiotics

• Author : Claudio O. Gualerzi
• Publisher : John Wiley & Sons
• File Size : 7,6 Mb
• Release Date : 2013-09-05
• Genre: Medical
• Pages : 576
• ISBN 10 : 9783527659708

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Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed. Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics. With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.

Experimental Chemotherapy

• Author : R Schnitzer
• Publisher : Elsevier
• File Size : 10,7 Mb
• Release Date : 1964-01-01
• Genre: Technology & Engineering
• Pages : 668
• ISBN 10 : 9780323143691

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Experimental Chemotherapy V3