Physiology and Pathology of Chloride Transporters and Channels in the Nervous System Book

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System


  • Author : Francisco J. Alvarez-Leefmans
  • Publisher : Academic Press
  • Release Date : 2009
  • Genre: Medical
  • Pages : 617
  • ISBN 10 : 0123743737
  • Total Read : 73
  • File Size : 17,5 Mb

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Physiology and Pathology of Chloride Transporters and Channels in the Nervous System Summary:

The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases.

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System Book

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System


  • Author : F. Javier Alvarez-Leefmans
  • Publisher : Academic Press
  • Release Date : 2009-08-22
  • Genre: Medical
  • Pages : 630
  • ISBN 10 : 0080922031
  • Total Read : 70
  • File Size : 6,5 Mb

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Physiology and Pathology of Chloride Transporters and Channels in the Nervous System Summary:

The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases. The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glyci

Cell Physiology Source Book Book
Score: 5
From 1 Ratings

Cell Physiology Source Book


  • Author : Nicholas Sperelakis
  • Publisher : Academic Press
  • Release Date : 2012-01-11
  • Genre: Science
  • Pages : 997
  • ISBN 10 : 9780123877383
  • Total Read : 83
  • File Size : 11,6 Mb

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Cell Physiology Source Book Summary:

Cell Physiology Source Book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The 4e contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, and synaptic transmission. Authored by leading researchers in the field Clear, concise, and comprehensive coverage of all aspects of cellular physiology, from fundamental concepts to more advanced topics Full color illustrations

Ion Channels and Transporters of Epithelia in Health and Disease Book

Ion Channels and Transporters of Epithelia in Health and Disease


  • Author : Kirk L. Hamilton
  • Publisher : Springer
  • Release Date : 2015-12-14
  • Genre: Medical
  • Pages : 1019
  • ISBN 10 : 9781493933662
  • Total Read : 85
  • File Size : 10,6 Mb

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Ion Channels and Transporters of Epithelia in Health and Disease Summary:

This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside. The individual chapters, written by leading scientists and clinicians, explore specific ion channels and transporters located in the epithelial tissues of the kidney, intestine, pancreas and respiratory tract, all of which play a crucial part in maintaining homeostasis. Further topics include the fundamentals of epithelial transport; mathematical modeling of ion transport; cell volume regulation; membrane protein folding and trafficking; transepithelial transport functions; and lastly, a discussion of transport proteins as potential pharmacological targets with a focus on the pharmacology of potassium channels.

Studies of Epithelial Transporters and Ion Channels Book

Studies of Epithelial Transporters and Ion Channels


  • Author : Kirk L. Hamilton
  • Publisher : Springer Nature
  • Release Date : 2021-03-04
  • Genre: Medical
  • Pages : 1247
  • ISBN 10 : 9783030554545
  • Total Read : 94
  • File Size : 19,6 Mb

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Studies of Epithelial Transporters and Ion Channels Summary:

This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. The authors will show, that each of these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their responsibility in maintaining homeostasis. The reader gains an understanding of the fundamentals of epithelial ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the third of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. The focus of this volume lies with different ion channel and transporter families. Additionally, this volume benefits from pharmaceutical contributors and their insights into recent pre-clinical drug discovery efforts and results from clinical trials. Overall, these chapters offer a more thorough coverage of individual epithelial ion channels and transporters from the 1st Edition, along with eleven new chapters. That makes Volume 3 an insightful contribution for physiology students, scientists and clinicians.

Cell Volume Regulation Book

Cell Volume Regulation


  • Author : Florian Lang
  • Publisher : S Karger Ag
  • Release Date : 1998
  • Genre: Science
  • Pages : 280
  • ISBN 10 : UOM:39015043125916
  • Total Read : 79
  • File Size : 11,7 Mb

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Cell Volume Regulation Summary:

This volume presents a unique compilation of reviews on cell volume regulation in health and disease, with contributions from leading experts in the field. The topics covered include mechanisms and signaling of cell volume regulation and the effect of cell volume on cell function, with special emphasis on ion channels and transporters, kinases and gene expression. Several chapters elaborate on how cell volume regulatory mechanisms participate in the regulation of epithelial transport, urinary concentration, metabolism, migration, cell proliferation and apoptosis. Last but not least, this publication is an excellent guide to the role of cell volume in the pathophysiology of hypercatabolism, diabetes mellitus, brain edema, hemoglobinopathies, tumor growth and metastasis, to name just a few. Providing deeper insights into an exciting area of research which is also of clinical relevance, this publication is a valuable addition to the library of those interested in cell volume regulation.

Erythrocytes Book
Score: 4
From 1 Ratings

Erythrocytes


  • Author : Florian Lang
  • Publisher : World Scientific Publishing Company
  • Release Date : 2012-07-23
  • Genre: Medical
  • Pages : 452
  • ISBN 10 : 9781908977083
  • Total Read : 81
  • File Size : 17,8 Mb

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Erythrocytes Summary:

The book covers the functional significance and properties of erythrocytes, their generation, senescence, and suicidal death. It further summarizes knowledge about hormones influencing erythrocyte formation including erythropoietin as well as disorders affecting and involving erythrocytes such as anemia, malaria, and sepsis. This seminal work forms a unique reference on the most abundant cell type in mammals and will be an invaluable resource for students in the life sciences.

Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders Book

Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-06-05
  • Genre: Science
  • Pages : 414
  • ISBN 10 : 9780128177655
  • Total Read : 82
  • File Size : 17,5 Mb

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Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders Summary:

Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders, Volume 83, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this volume presenting chapters from recognized experts on topics such as cardiotonic steroids, Na+, K+ pumps and vascular fibrosis, purinergic signaling in the lung, structural models of a2-subunit N-termini and binding interfaces, ubiquitous and cell type-specific transcriptomic changes triggered by dissipation of monovalent cation gradients, the Na, K-ATPase alpha2 isoform in cardiovascular pathologies, the role of cell swelling and volume-sensitive ion channels in stroke pathology, structure-function relationships in the renal NaCl cotransporter, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Membranes series Includes the latest information on membrane ion transporters