Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection Book

Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection


  • Author : Naseer Ahmed, MD, PhD
  • Publisher : Academic Press
  • Release Date : 2019-08-15
  • Genre: Science
  • Pages : 208
  • ISBN 10 : 0128180234
  • Total Read : 90
  • File Size : 20,9 Mb

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Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection Summary:

Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection explores the physiology and pathophysiology of myocardial metabolism under normal and ischemic conditions. It examines current advancements and limitations of treatment, as well as prevention tactics that can be used against myocardial ischemia-reperfusion injury, also providing insights into potential new therapies. This concise, yet rigorous, coverage outlines an innovative cardioprotection strategy with insights into the mechanisms of myocardial ischemia-reperfusion injury and the role of fingolimod as a cardioprotective due to its anti-oxidant, anti-apoptotic and anti-inflammatory pathways. Provides detailed and critical analysis of the latest research in the field, from molecular basis, to potential clinical relevance Examines the effect of fingolimod/sphingosine 1-phosphate in cardioprotection, pointing to future myocardial preventative strategies Presents full coverage of the mechanisms of ischemia reperfusion injury

Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection Book

Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection


  • Author : Naseer Ahmed
  • Publisher : Academic Press
  • Release Date : 2019-05-30
  • Genre: Science
  • Pages : 140
  • ISBN 10 : 9780128182536
  • Total Read : 64
  • File Size : 19,6 Mb

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Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection Summary:

Pathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is a deep examination into the mechanisms of myocardial ischemiareperfusion injury and role of fingolimod as a cardioprotective agent through its antioxidant, anti-apoptotic and anti-inflammatory effects. Dr. Ahmed explore the physiology and pathophysiology of myocardial metabolism under normal and ischemic conditions and focused on pharmacological cardioprotection. They provide a concise, yet rigorous discussion of Ischemia-Reperfusion Injury, Myocardial Ischemia during Circulatory Arrest, Myocardial Reperfusion, Myocardial Protection related to Ischemia-Reperfusion Injury and Role of Fingolimod in Cardioprotection. Pathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is ideal for researchers, cardiovascular scientists, and clinical pharmacologists to further work in this challenging area and apply this knowledge to clinical trials for cardioprotection. Provides detailed and critical analysis of the latest research in the field from molecular basis to potential clinical relevance Examines the effect of fingolimod/sphingosine 1-phosphate in cardioprotection, pointing to future myocardial preventative strategies

Novel Therapeutic Targets and Emerging Treatments for Fibrosis Book

Novel Therapeutic Targets and Emerging Treatments for Fibrosis


  • Author : Chrishan S. Samuel
  • Publisher : Frontiers Media SA
  • Release Date : 2018-01-12
  • Genre: Uncategoriezed
  • Pages : 162
  • ISBN 10 : 9782889453726
  • Total Read : 79
  • File Size : 12,7 Mb

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Novel Therapeutic Targets and Emerging Treatments for Fibrosis Summary:

For decades we have known that the overgrowth, hardening and scarring of tissues (so-called fibrosis) represents the final common pathway and best histological predictor of disease progression in most organs. Fibrosis is the culmination of both excess extracellular matrix deposition due to ongoing or severe injury, and a failure to regenerate. An inadequate wound repair process ultimately results in organ failure through a loss of function, and is therefore a major cause of morbidity and mortality in disease affecting both multiple and individual organs. Whilst the pathology of fibrosis and its significance are well understood, until recently we have known little about its molecular regulation. Current therapies are often indirect and non-specific, and only slow progression by a matter of months. The recent identification of novel therapeutic targets, and the development of new treatment strategies based on them, offers the exciting prospect of more efficacious therapies to treat this debilitating disorder. This Research Topic therefore compromises several up-to-date mini-reviews on currently known and emerging therapeutic targets for fibrosis including: the Transforming Growth Factor (TGF)-family; epigenetic factors; Angiotensin II type 2 (AT2) receptors; mineralocorticoid receptors; adenosine receptors; caveolins; and the sphingosine kinase/sphingosine 1-phosphate and notch signaling pathways. In each case, mechanistic insights into how each of these factors contribute to regulating fibrosis progression are described, along with how they can be targeted (by existing drugs, small molecules or other mimetics) to prevent and/or reverse fibrosis and its contribution to tissue dysfunction and failure. Two additional reviews will discuss various anti-fibrotic therapies that have demonstrated efficacy at the experimental level, but are not yet clinically approved; and the therapeutic potential vs limitations of stem cell-based therapies for reducing fibrosis while facili

Cerebral Ischemic Reperfusion Injuries  CIRI  Book

Cerebral Ischemic Reperfusion Injuries CIRI


  • Author : Weijian Jiang
  • Publisher : Springer
  • Release Date : 2018-06-29
  • Genre: Medical
  • Pages : 259
  • ISBN 10 : 9783319901947
  • Total Read : 59
  • File Size : 6,5 Mb

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Cerebral Ischemic Reperfusion Injuries CIRI Summary:

This volume is focused on subjects related to cerebral ischemia and reperfusion injuries after acute stroke. All chapters are selected from the Sixth Elite Stroke meeting named Pangu Stroke Conference and written by members of world leading laboratories of stroke studies. The contents cover both clinical and bench studies, from basic components of cerebral arterial system to clinical reperfusion injury cases, from reperfusion caused programmed cell death and astrocyte activation to oxidative stress and nitric oxide after reperfusion, from extracellular matrix and inflammation to a role of diabetes after reperfusion, from small artery disorders to collateral circulation and blood pressure control after reperfusion. Wei-Jian Jiang, Chairman of New Era Stroke Care and Research Institute of PLA Rocket Force General Hospital, Beijing, China. Wengui Yu, Professor and Director of Comprehensive Stroke & Cerebrovascular Center, University of California, Irvine Yan Qu, Professor and Director of Neurosurgery at the Second Affiliated Hospital of Air Force Medical University, Xi’an, China. Zhongsong Shi, Professor of Neurosurgery at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Ben-yan Luo, Professor and Chair of Neurology at the First Affiliated Hospital of Zhejiang University. John H. Zhang, Professor of Anesthesiology and Physiology at Loma Linda University School of Medicine, Loma Linda, CA, USA.

The Role of Bioactive Lipids in Cancer  Inflammation and Related Diseases Book

The Role of Bioactive Lipids in Cancer Inflammation and Related Diseases


  • Author : Kenneth V. Honn
  • Publisher : Springer Nature
  • Release Date : 2019-09-27
  • Genre: Medical
  • Pages : 257
  • ISBN 10 : 9783030217358
  • Total Read : 89
  • File Size : 9,5 Mb

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The Role of Bioactive Lipids in Cancer Inflammation and Related Diseases Summary:

The Organizing Committee of the 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases compiled a group of junior investigators to provide reviews on the topics they presented at the Puerto Vallarta Bioactive Lipids conference, as part of the book series, Advances in Experimental Medicine and Biology (AEMB). The book in this series will be titled Bioactive Lipids in Cancer, Inflammation and Related Diseases. Topics range from all classes of lipids including prostaglandins, resolvins, spingolipids, P450-derived lipids, endocannabanoids and phospholipids. The focus includes physiology, cell biology, and structural studies in organisms from bacteria to humans and how these studies addressed the role of lipids in various disease i.e. cancer, inflammation, diabetes, obesity, cardiovascular disease and others.

Sudden arrhythmic death  from basic science to clinical practice Book

Sudden arrhythmic death from basic science to clinical practice


  • Author : Gareth D. Matthews
  • Publisher : Frontiers E-books
  • Release Date : 2014-10-02
  • Genre: Cardiac arrest
  • Pages : 137
  • ISBN 10 : 9782889192694
  • Total Read : 74
  • File Size : 11,7 Mb

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Sudden arrhythmic death from basic science to clinical practice Summary:

With upwards of 4.5 million deaths worldwide each year, and more than one tenth of these occurring in those with no previously documented heart disease, sudden arrhythmic death (SAD) is both a major public health burden and a highly emotive issue for society at large. Recent years have witnessed a marked expansion in our knowledge of the physiology underlying SAD, both in the context of hereditary and acquired cardiac disorders. Thanks largely to work in genetically modified animals, the growth in our understanding of mechanisms underlying arrhythmia in the hereditary channelopathies has been particularly marked. Our growing knowledge of the fundamental mechanisms underlying SAD has so far failed to spur substantial developments in clinical practice. Despite a large body of work in both humans and animals, it remains impossible to confidently identify those at high risk of SAD, making pre-emptive therapy a challenge. What is more, with the thankful exception of the implantable cardioverter-defibrillators and pharmacological agents in very specific situations, there has been depressingly little progress in finding new and effective therapies. This Research Topic aims to go some way towards bridging the gap between advances in basic science and the development and delivery of new therapies. It brings together original research contributions and review articles from key opinion leaders in the field, focusing on the direct clinical implications of the basic science research now and in the future

Botanical Leads for Drug Discovery Book

Botanical Leads for Drug Discovery


  • Author : Bikarma Singh
  • Publisher : Springer Nature
  • Release Date : 2020-10-05
  • Genre: Medical
  • Pages : 468
  • ISBN 10 : 9789811559174
  • Total Read : 73
  • File Size : 12,6 Mb

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Botanical Leads for Drug Discovery Summary:

Active botanical ingredients are a prime requirement for herbal formulations and discovering a drug is all about integration of science disciplines. In recent decades there has been a growing interest in treating wounds and diseases using traditional remedies based on local herbs, combined with chemical advances. Although this has led to the development of new bioactive ingredients from plants, there has been little success in terms of clinical trials and post-marketing studies to comply with FDA guidelines. Plants have been used as a source of medicine throughout history and continue to serve as the basis for many pharmaceuticals used today. However, despite the modern pharmaceutical industry being founded on botanical medicine, synthetic approaches to drug discovery have now become standard. Science-driven translational discovery and botanical development has created a new reality, leading to enormous changes in strategies, technologies and the disciplines involved, which have been embraced by the pharmaceutical and biotech industries. This book gathers scientific expertise and traditional knowledge to promote the discovery and development of new formulations and drugs based on active ingredients and to provide guidance on taking these to clinical trials. It discusses major topics, such as how the phytochemical composition of many plants has changed over time due to factors like cultivation, which can have both positive and negative effects on the levels of bioactive compounds. It also explores the importance of plants as a valuable source of therapeutic compounds as a result of their vast biosynthetic capacity, and classifies them according to their intended use, safety and regulatory status. Further, the book offers insights into the regulatory aspects of botanical products, which is an important issue when considering standardization and quality assessment, and also examines the commercial aspects of plant-derived medications and their proven role in the treatm