Clinical Studies and Therapies in Parkinson s Disease Book

Clinical Studies and Therapies in Parkinson s Disease


  • Author : Juan Segura-Aguilar
  • Publisher : Academic Press
  • Release Date : 2021-06-12
  • Genre: Medical
  • Pages : 306
  • ISBN 10 : 9780128221587
  • Total Read : 65
  • File Size : 15,8 Mb

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Clinical Studies and Therapies in Parkinson s Disease Summary:

More than 50 years have passed since the use of L-dopa in the palliative treatment of Parkinson’s disease, but it remains the most common treatment despite inducing severe side effects such as dyskinesia after 4–6 years of use. Numerous preclinical investigations based on endogenous neurotoxin models have promised various therapies for Parkinson’s disease, but these efforts have failed when attempting to transfer these successful results to preclinical studies. Although several publications have warned of these failures, the scientific community remains mostly unaware, and there is a need to focus their efforts on potential therapeutics that can slow or halt development of the disease. Clinical Studies and Therapies in Parkinson’s Disease: Translations from Preclinical Models analyzes preclinical models based on exogenous neurotoxins and why they have failed. Neuroscientists, neurologists, and neuropharmacologists will benefit greatly from the book’s discussion of these newer models, their benefits, and the need for their implementation. This book also provides the basic concepts of dopamine metabolism for students taking courses in neurochemistry, neuroscience, neuropharmacology, biochemistry, and medicine. Reviews Parkinson's disease classification, pharmacological therapies, and nonmotor and motor symptoms Analyzes preclinical models of Parkinson’s disease therapies based on exogenous neurotoxins and why they have failed Reviews genetic preclinical models based on genetic mutations and endogenous neurotoxins Proposes a more physiological model directly related to the metabolism of dopaminergic neurons Provides the basic concepts and mechanisms of dopamine metabolism

Therapeutics of Parkinson s Disease and Other Movement Disorders Book

Therapeutics of Parkinson s Disease and Other Movement Disorders


  • Author : Mark Hallett
  • Publisher : John Wiley & Sons
  • Release Date : 2008-10-13
  • Genre: Medical
  • Pages : 520
  • ISBN 10 : 9780470714003
  • Total Read : 79
  • File Size : 15,7 Mb

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Therapeutics of Parkinson s Disease and Other Movement Disorders Summary:

Provides a comprehensive update on therapies for Parkinson’s disease and other movement disorders Describes the basic mechanisms of neurodegeneration, pharmacologic interventions for motor and non-motor symptoms, and surgical management Features summary tables and algorithms that serve as a quick reference guide for practical treatment decisions The expert guidance of recognised authorities will enable readers of this book to plan their patients’ care with greater confidence

Leucine Rich Repeat Kinase 2  LRRK2  Book

Leucine Rich Repeat Kinase 2 LRRK2


  • Author : Hardy J. Rideout
  • Publisher : Springer
  • Release Date : 2017-03-28
  • Genre: Medical
  • Pages : 271
  • ISBN 10 : 9783319499697
  • Total Read : 68
  • File Size : 18,8 Mb

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Leucine Rich Repeat Kinase 2 LRRK2 Summary:

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.

Levodopa Induced Dyskinesia in Parkinson s Disease Book

Levodopa Induced Dyskinesia in Parkinson s Disease


  • Author : Susan H. Fox
  • Publisher : Springer
  • Release Date : 2014-10-08
  • Genre: Medical
  • Pages : 368
  • ISBN 10 : 9781447165033
  • Total Read : 92
  • File Size : 15,5 Mb

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Levodopa Induced Dyskinesia in Parkinson s Disease Summary:

This book aims to provide a single reference source on levodopa-induced dyskinesias (LID) from ‘bench to bedside’. Initial chapters review the clinical features and phenomenology of LID with video examples; epidemiology and genetic risk factors for LID are covered as a background to understanding risk factors for developing LID. The following chapters cover the latest preclinical studies aiming to understand the pathophysiology of LID at the cellular, neurochemical, neurophysiological and circuitry level with detailed discussion of mechanisms and future directions to take the field forward; clinical studies from phase II to phase IV; on going RCTs in LID and evidence-based medicine reviews of treatment options. Levodopa-Induced Dyskinesia in Parkinson’s Disease is aimed at an international audience of movement disorder neurologists; neuroscientists; trainees and graduate and post-graduate students.

Parkinson s Disease Book

Parkinson s Disease


  • Author : Sarat Chandra Yenisetti
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-05-30
  • Genre: Medical
  • Pages : 128
  • ISBN 10 : 9781789231526
  • Total Read : 94
  • File Size : 18,9 Mb

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Parkinson s Disease Summary:

Parkinson's disease (PD) is the second most common neurodegenerative disorder results due to loss of dopamine producing brain cells. Knowledge relating to PD condition has been known since 5000BC, however no effective therapeutic strategies are available till today. Therefore it is important for neurobiologists to work further by taking advantage of modern scientific methods and develop appropriate therapeutic strategies. Efforts in this direction are worthy as they will reduce the burden of PD among elderly, who are already burdened with age related systemic degenerative processes. This book is a humble effort in that progressive direction. It has chapters covering multiple aspects relating to etiology, pathophysiology of PD, available and futuristic therapeutics strategies. Therefore it will be of interest to common man, biomedical researchers and clinicians. This is one small step in a direction "to reduce the burden of neurological disease."

Non Motor Symptoms of Parkinson s Disease Book

Non Motor Symptoms of Parkinson s Disease


  • Author : K. Ray Chaudhuri
  • Publisher : Oxford University Press, USA
  • Release Date : 2014
  • Genre: Medical
  • Pages : 517
  • ISBN 10 : 9780199684243
  • Total Read : 64
  • File Size : 18,7 Mb

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Non Motor Symptoms of Parkinson s Disease Summary:

Patients with Parkinson's disease (PD) are known to suffer from motor symptoms of the disease, but they also experience non-motor symptoms (NMS) that are often present before diagnosis or that inevitably emerge with disease progression. The motor symptoms of Parkinson's disease have been extensively researched, and effective clinical tools for their assessment and treatment have been developed and are readily available. In contrast, researchers have only recently begun to focus on the NMS of Parkinson's Disease, which are poorly recognized and inadequately treated by clinicians. The NMS of PD have a significant impact on patient quality of life and mortality and include neuropsychiatric, sleep-related, autonomic, gastrointestinal, and sensory symptoms. While some NMS can be improved with currently available treatments, others may be more refractory and will require research into novel (non-dopaminergic) drug therapies for the future. Edited by members of the UK Parkinson's Disease Non-Motor Group (PD-NMG) and with contributions from international experts, this new edition summarizes the current understanding of NMS symptoms in Parkinson's disease and points the way towards future research.

Etiology of Parkinson s Disease Book

Etiology of Parkinson s Disease


  • Author : Jonas H. Ellenberg
  • Publisher : CRC Press
  • Release Date : 1995-03-01
  • Genre: Medical
  • Pages : 600
  • ISBN 10 : 0824788230
  • Total Read : 68
  • File Size : 12,9 Mb

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Etiology of Parkinson s Disease Summary:

This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.

Parkinson s Disease Book

Parkinson s Disease


  • Author : Richard Nass
  • Publisher : Elsevier
  • Release Date : 2011-04-28
  • Genre: Psychology
  • Pages : 686
  • ISBN 10 : 0080559581
  • Total Read : 60
  • File Size : 15,8 Mb

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Parkinson s Disease Summary:

Parkinson’s disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both in unaffected and diseased cells are now providing new insights into the molecular basis of the neurodegeneration, as well as therapeutic approaches. In this reference, we will describe the advances and the advantages that various invertebrates, cell culture, rodents, and mammals provide in the identification of the molecular components and mechanisms involved in the cell death, and outline the opportunities that these systems provide in drug discovery. Comprehensive and critical assessment of the utility of various model systems to identify the molecular components and pathways involved in Parkinson’s disease Describes the power of toxin and genetic models to identify novel therapeutic targets and compounds that can be used in PD Current overviews of current status of PD research and discovery from bench-to-bedside Provides novel insights and views on where the future of PD research may lead Provides a powerful teaching tool and template to explore the utility of model systems to identify molecular pathways, molecular targets, and therapeutics that are applicable to a variety of neurological diseases