Nucleic Acids in Chemistry and Biology Book

Nucleic Acids in Chemistry and Biology


  • Author : G Michael Blackburn
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-11-09
  • Genre: Science
  • Pages : null
  • ISBN 10 : 9781782625773
  • Total Read : 84
  • File Size : 18,7 Mb

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Nucleic Acids in Chemistry and Biology Summary:

The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.

The Chemical Biology of Nucleic Acids Book

The Chemical Biology of Nucleic Acids


  • Author : Günter Mayer
  • Publisher : John Wiley & Sons
  • Release Date : 2011-06-17
  • Genre: Science
  • Pages : 478
  • ISBN 10 : 9781119957263
  • Total Read : 81
  • File Size : 7,7 Mb

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The Chemical Biology of Nucleic Acids Summary:

With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNA expansion of the genetic alphabet in nucleic acids by creating new base pairs chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides nucleic-acid-templated chemistry chemical biology of peptide nucleic acids (PNA) the interactions of small molecules with DNA and RNA the architectural modules of folded RNAs genesis and biological applications of locked nucleic acid (LNA) small non-coding RNA in bacteria microRNA-guided gene silencing nucleic acids based therapies innate immune recognition of nucleic acid light-responsive nucleic acids for the spatiotemporal control of biological processes DNA methylation frameworks for programming RNA devices RNA as a catalyst: The Diels-Alderase-Ribozyme evolving an understanding of RNA function by in vitro approaches the chemical biology of aptamers: synthesis and applications nucleic acids as detection tools bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.

Advanced Organic Chemistry of Nucleic Acids Book

Advanced Organic Chemistry of Nucleic Acids


  • Author : Zoe A. Shabarova
  • Publisher : John Wiley & Sons
  • Release Date : 2008-07-11
  • Genre: Science
  • Pages : 603
  • ISBN 10 : 9783527615926
  • Total Read : 67
  • File Size : 10,6 Mb

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Advanced Organic Chemistry of Nucleic Acids Summary:

Sequencing, cloning, transcription - these are but a few key techniques behind the current breathtaking advances in molecular biology and biochemistry. As these methods continuosly diversify, biochemists need a sound chemical understanding to keep the pace. Chemists beginning working in the molecular biology lab need an introduction to this field from their point of view. This book serves both: it describes most of the known chemical reactions of nucleosides, nucleotides, and nucleic acids in sufficient detail to provide the desired background, and additionally, the fundamental relations between sequence, structure and functionality of nucleic acids are presented. The first edition of this book, which was published in Russian, has immediately become a recognized standard reference. This second, thoroughly revised and updated edition, now published in English, is likely to achieve a similar position in the international scientific community.

Dynamics of Proteins and Nucleic Acids Book

Dynamics of Proteins and Nucleic Acids


  • Author : J. Andrew McCammon
  • Publisher : Cambridge University Press
  • Release Date : 1988-04-29
  • Genre: Science
  • Pages : 256
  • ISBN 10 : 0521356520
  • Total Read : 62
  • File Size : 5,7 Mb

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Dynamics of Proteins and Nucleic Acids Summary:

This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity. The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimental studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function. The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers), biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.

Nucleic Acids Book

Nucleic Acids


  • Author : Marcelo Larramendy
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-03-16
  • Genre: Science
  • Pages : 222
  • ISBN 10 : 9789535122647
  • Total Read : 84
  • File Size : 16,6 Mb

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Nucleic Acids Summary:

This edited book, "Nucleic Acids - From Basic Aspects to Laboratory Tools", contains a series of chapters that highlight the development and status of the various aspects of the nucleic acids related to DNA chemistry and biology and the molecular application of these small DNA molecules and related synthetic analogues within biological systems. Furthermore, it is hoped that the information in the present book will be of value to those directly engaged in the handling and use of nucleic acids, and that this book will continue to meet the expectations and needs of all who are interested in the different fascinating aspects of molecular biology.

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids Book

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids


  • Author : Surendra Nimesh
  • Publisher : Woodhead Publishing
  • Release Date : 2017-04-04
  • Genre: Science
  • Pages : 256
  • ISBN 10 : 9780081005637
  • Total Read : 62
  • File Size : 11,7 Mb

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Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids Summary:

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc. Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies

Spherical Nucleic Acids Book

Spherical Nucleic Acids


  • Author : Chad A. Mirkin
  • Publisher : CRC Press
  • Release Date : 2020-09-01
  • Genre: Medical
  • Pages : 1806
  • ISBN 10 : 9780429578069
  • Total Read : 61
  • File Size : 13,6 Mb

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Spherical Nucleic Acids Summary:

Spherical nucleic acids (SNAs) comprise a nanoparticle core and a densely packed and highly oriented nucleic acid shell, typically DNA or RNA. They have novel architecture-dependent properties that distinguish them from all other forms of nucleic acids and make them useful in materials synthesis, catalysis, diagnostics, therapeutics, and optics/plasmonics. This book covers over two decades of Dr. Mirkin’s research on SNAs and their anisotropic analogues, including synthesis and fundamental properties, and applications in colloidal crystallization, adaptive matter, and nanomedicine, spanning extra- and intracellular diagnostics, gene regulation, and immunomodulation. It is a reprint volume that compiles 101 key papers from high-impact journals in this research area published by the Mirkin Group at Northwestern University, Illinois, USA, within the International Institute for Nanotechnology, and collaborators. Volume 1 provides an overview and a historical framework of engineering matter from DNA-modified constructs and discusses the enabling features of nucleic acid–functionalized nanomaterials. Volume 2 covers design rules for colloidal crystallization, building blocks for crystal engineering, and DNA and RNA as programmable bonds. Volume 3 discusses colloidal crystallization processes and routes to hierarchical assembly, dynamic nanoparticle superlattices, surface-based and template-confined colloidal crystallization, optics and plasmonics with nanoparticle superlattices, and postsynthetic modification and catalysis with nanoparticle superlattices. Volume 4 covers diagnostic modalities, and intracellular therapeutic and diagnostic schemes based upon nucleic acid–functionalized nanomaterials.

The Chemistry of Nucleic Acids Book

The Chemistry of Nucleic Acids


  • Author : Denis Oswald Jordan
  • Publisher : Unknown
  • Release Date : 1960
  • Genre: Nucleic acids
  • Pages : 390
  • ISBN 10 : UOM:39015065775994
  • Total Read : 83
  • File Size : 13,9 Mb

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The Chemistry of Nucleic Acids Summary: