Neuronal Chloride Transporters in Health and Disease Book

Neuronal Chloride Transporters in Health and Disease


  • Author : Xin Tang
  • Publisher : Academic Press
  • Release Date : 2020-06
  • Genre: Medical
  • Pages : 650
  • ISBN 10 : 0128153180
  • Total Read : 81
  • File Size : 13,8 Mb

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Neuronal Chloride Transporters in Health and Disease Summary:

Neuronal Chloride Transporters in Health and Disease introduces core concepts and recent advances surrounding the physiology and pathophysiology of neuronal chloride transporters, with particular focus on the KCC and NKCC families of proteins. Chloride transporter biology is reviewed, including its role in setting the transmembrane chloride gradient and in chloride transport-independent functions, such as regulating excitatory neurotransmission. Chapters also address post-translational modifications and the trafficking of chloride transporters, protein interaction partners, and the genetic and environmental factors that regulate expression in neurons. This new volume will provide readers with an up-to-date summary on recent advances in neuronal chloride transporter research, with a particular emphasis on key and emerging topics in the field.

Neuronal Chloride Transporters in Health and Disease Book

Neuronal Chloride Transporters in Health and Disease


  • Author : Xin Tang
  • Publisher : Academic Press
  • Release Date : 2020-06-19
  • Genre: Medical
  • Pages : 766
  • ISBN 10 : 9780128153192
  • Total Read : 95
  • File Size : 11,6 Mb

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Neuronal Chloride Transporters in Health and Disease Summary:

In the past several years, there has been an exciting body of new research that links impairments in the expression or function of neuronal chloride transporters to a growing number of diseases spanning from autism to brain aging. This book introduces the core concepts and highlights the recent advances in understanding the physiology and pathophysiology of the KCC and NKCC families of neuronal chloride transporters. Neuronal chloride transporter biology is reviewed, including roles in setting the transmembrane chloride gradient and the chloride transport-independent functions, such as regulating excitatory neurotransmission. Chapters are also dedicated to addressing the structure, post-translational modification, membrane trafficking, and protein interaction partners of neuronal chloride transporters, as well as the genetic and environmental factors that regulate their expression in neurons and the novel therapeutic approaches that target neuronal chloride transporters to treat neurological diseases. This new volume will provide readers with an up-to-date summary of the recent advances in neuronal chloride transporter research, with particular emphasis on some of the key emerging topics in the field. Summarizes roles of KCCs and NKCCs in regulating inhibitory and excitatory neurotransmission Reviews the molecular and cellular biology of neuronal chloride transporters Links neuronal chloride transporter deficiencies to autism, epilepsy, depression, and more Identifies role of transporter deficiencies in pain as well as brain and spinal cord injury Discusses drug research targeting neuronal chloride transporters for nervous system diseases

Insights in Cellular Neurophysiology  2021 Book

Insights in Cellular Neurophysiology 2021


  • Author : Enrico Cherubini
  • Publisher : Frontiers Media SA
  • Release Date : 2022-11-08
  • Genre: Science
  • Pages : 231
  • ISBN 10 : 9782832504550
  • Total Read : 62
  • File Size : 11,8 Mb

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Insights in Cellular Neurophysiology 2021 Summary:

Ion Channels in Health and Disease Book

Ion Channels in Health and Disease


  • Author : Geoffrey S. Pitt
  • Publisher : Academic Press
  • Release Date : 2016-10-04
  • Genre: Science
  • Pages : 392
  • ISBN 10 : 9780128020173
  • Total Read : 82
  • File Size : 15,5 Mb

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Ion Channels in Health and Disease Summary:

Ion Channels in Health and Disease provides key insight to allow researchers to generate discoveries across disease states. A single resource that integrates disparate areas of biology and disease ion channel biology, this publication includes cross-referencing for disease, channels, and tissues. Offers a broad view of research of interest to early and experienced researchers across biological and biomedical research. Provides an overview of fundamental concepts in ion channels research to link defects in human disease Written in an accessible manner, without jargon Provides a helpful, easy cross-reference for diseases, channels, and tissues

Glutamate Related Biomarkers in Drug Development for Disorders of the Nervous System Book

Glutamate Related Biomarkers in Drug Development for Disorders of the Nervous System


  • Author : Institute of Medicine
  • Publisher : National Academies Press
  • Release Date : 2011-07-05
  • Genre: Medical
  • Pages : 74
  • ISBN 10 : 9780309212243
  • Total Read : 88
  • File Size : 10,9 Mb

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Glutamate Related Biomarkers in Drug Development for Disorders of the Nervous System Summary:

Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.