Neurobiology of Depression Book
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Neurobiology of Depression


  • Author : Joao Luciano de Quevedo
  • Publisher : Academic Press
  • Release Date : 2019-01-03
  • Genre: Medical
  • Pages : 471
  • ISBN 10 : 9780128133347
  • Total Read : 67
  • File Size : 8,6 Mb

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Neurobiology of Depression Summary:

Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD. Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness. Aids readers in understanding major depressive disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments, to antidepressants and novel therapeutics Synthesizes discussions on the cellular and molecular mechanisms underlying symptoms with the clinical aspects of depression

Neurobiology of Depression Book

Neurobiology of Depression


  • Author : Francisco Lopez-Munoz
  • Publisher : CRC Press
  • Release Date : 2011-09-09
  • Genre: Medical
  • Pages : 526
  • ISBN 10 : 9781439838501
  • Total Read : 73
  • File Size : 16,7 Mb

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Neurobiology of Depression Summary:

Major depressive disorders have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways hold promise as new therapeutics for depression. With the collaboration of the most prestigious international specialists in biochemistry, molecular biology, genomics, psychiatry, psychology, and pharmacology, Neurobiology of Depression discusses the nature of the central nervous system circuits responsible for the modifications of neuronal functioning that lead to depression. The book begins by discussing animal, neurophysiological, and neuropsychological models of depression as well as neural foundations. It explores genetic factors that contribute to depression and describes the effect of monoaminergic systems in the central nervous system. Next, the book profiles the rise of psychopharmacology in the treatment of depression and the research into serotonin and monoamine reuptake inhibitors. It examines the role of the glutamatergic, endocannabinoid, and opioid systems in the pathophysiology of mood disorders, as well as the effect of biological rhythms on the human body. Later chapters review the role of CRF-related ligands, CRF receptors, HPA axis activity, and glucocorticoid receptors in the regulation of the stress response and depression. They also describe cytokine modulation of molecular mechanisms. They examine the role of neuropeptide Y, nitric oxide, beta-arrestins, BDNF, and phosphodiesterases, and discuss the use of tachykinin antagonists in treatment. Finally, they analyze the neurobiological basis for the development of new antidepressant agents. Exploring myriad aspects of a disease that plagues a large percentage of the population worldwide, this volume captures the state of the science of this debilitating disorder, facilitating further research and discovery.

Systems Neuroscience in Depression Book

Systems Neuroscience in Depression


  • Author : Thomas Frodl
  • Publisher : Academic Press
  • Release Date : 2016-09-01
  • Genre: Psychology
  • Pages : 420
  • ISBN 10 : 9780128026281
  • Total Read : 68
  • File Size : 13,9 Mb

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Systems Neuroscience in Depression Summary:

Systems Neuroscience in Depression provides a comprehensive overview of the normal and depressed brain processes as studied from a systems neuroscience perspective. Systems neuroscience uses a wide variety of approaches to study how networks of neurons form the bases of higher brain function. A broad overview is discussed starting with a background from neurodevelopment and neural understanding as well as novel treatment approaches for depression. This book covers basic developmental aspects and depressive psychopathology, as well as the basic scientific background from animal models and experimental research. Current advances in systems neuroscience are highlighted in studies from child and adolescent psychiatry. Integrated approaches are presented with regards to genetics, neuroimaging and neuroinflammation as well as neuroendocrinology. The field of systems and network neuroscience is evolving rapidly and this book provides a greatly needed resource for researchers and practitioners in systems neuroscience and psychiatry. Knowledge covering the whole life span from early to later life Comprehensively written chapters developing from molecules via epigenetics and neural circuits to clinical neuroscience Understanding the neurobiology of major depressive disorder Integrating stress and environmental factors with molecular underpinnings More than 25 illustrations and tables

The Neurobiological Basis of Suicide Book

The Neurobiological Basis of Suicide


  • Author : Yogesh Dwivedi
  • Publisher : CRC Press
  • Release Date : 2012-06-25
  • Genre: Medical
  • Pages : 482
  • ISBN 10 : 9781439838815
  • Total Read : 73
  • File Size : 9,8 Mb

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The Neurobiological Basis of Suicide Summary:

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Rapid Acting Antidepressants Book

Rapid Acting Antidepressants


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-06-29
  • Genre: Medical
  • Pages : 402
  • ISBN 10 : 9780128201909
  • Total Read : 72
  • File Size : 5,8 Mb

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Rapid Acting Antidepressants Summary:

The Advances in Pharmacology series presents a variety of chapters from the best authors in the field. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Neuropsychology of Depression Book

Neuropsychology of Depression


  • Author : Shawn M. McClintock
  • Publisher : Guilford Publications
  • Release Date : 2022-02-20
  • Genre: Psychology
  • Pages : 464
  • ISBN 10 : 9781462549337
  • Total Read : 76
  • File Size : 5,6 Mb

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Neuropsychology of Depression Summary:

Timely and authoritative, this unique volume focuses on neurocognitive aspects of depression and their implications for assessment, evaluation, clinical management, and research. Experts in the field explore the impact of depression on executive function, learning and memory, working memory, and other critical capacities, and present cutting-edge assessment tools and procedures. The neurocognitive effects of widely used antidepressant treatments are reviewed, from psychotropic medications and evidence-based psychotherapies to established and emerging neuromodulation technologies. Practical aspects of working with adults across the lifespan with depression are addressed, including ways to strengthen treatment engagement and adherence, and to incorporate cultural considerations.

Charney   Nestler s Neurobiology of Mental Illness Book

Charney Nestler s Neurobiology of Mental Illness


  • Author : Dennis S. Charney
  • Publisher : Oxford University Press
  • Release Date : 2018-01-12
  • Genre: Medical
  • Pages : 1024
  • ISBN 10 : 9780190681425
  • Total Read : 61
  • File Size : 16,8 Mb

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Charney Nestler s Neurobiology of Mental Illness Summary:

Preceded by Neurobiology of mental illness / edited by Dennis S. Charney ... [et al.]. 4th ed. 2013.

Melancholia  A Disorder of Movement and Mood Book

Melancholia A Disorder of Movement and Mood


  • Author : Gordon Parker
  • Publisher : Cambridge University Press
  • Release Date : 1996-03-29
  • Genre: Medical
  • Pages : 356
  • ISBN 10 : 052147275X
  • Total Read : 69
  • File Size : 19,5 Mb

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Melancholia A Disorder of Movement and Mood Summary:

Describes the development of a new approach to the diagnosis and pathogenesis of melancholic depression.