Mouse Behavioral Testing Book

Mouse Behavioral Testing


  • Author : Douglas Wahlsten
  • Publisher : Academic Press
  • Release Date : 2010-11-25
  • Genre: Nature
  • Pages : 304
  • ISBN 10 : 0123756758
  • Total Read : 83
  • File Size : 19,7 Mb

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Mouse Behavioral Testing Summary:

Mouse Behavioral Testing: How to Use Mice in Behavioral Neuroscience provides detailed explanations of how to conduct an experiment on mouse behavior from the initial planning of the research design through every step of the process until the data analysis phase. The book discusses the practical matters that need to be considered carefully when working with any species of animal, such as how many animals need to be tested. It describes the tests and techniques devised specifically for work with mice. Every step of the research process is illustrated with real situations encountered in previous studies. All examples are based on real experiments, and extensive details of several published experiments are provided. The essential features of a behavioral test protocol are outlined, and several complete protocols are provided. Methods to balance the order of tests and determine throughput are described, then a completely balanced order of tests in a complex experiment is presented. The book will be useful for those already familiar with the general principles of research but are new to the realm of behavioral testing of live mice. It will also serve as a text for a formal course, most likely at the graduate level. A guide to running a behavioral testing lab, including the many aspects of mouse research beyond the confines of the specific test Diagrams and photographs are shown for many kinds of apparatus and test situations with sufficient details such as dimensions to enable building of replicas Provides step-by-step instructions on planning and executing behavioral experiments in order to run them successfully

Methods of Behavior Analysis in Neuroscience Book

Methods of Behavior Analysis in Neuroscience


  • Author : Jerry J. Buccafusco
  • Publisher : CRC Press
  • Release Date : 2000-08-29
  • Genre: Medical
  • Pages : 352
  • ISBN 10 : 9781420041811
  • Total Read : 89
  • File Size : 12,7 Mb

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Methods of Behavior Analysis in Neuroscience Summary:

Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

What s Wrong With My Mouse  Book

What s Wrong With My Mouse


  • Author : Jacqueline N. Crawley
  • Publisher : John Wiley & Sons
  • Release Date : 2007-05-11
  • Genre: Science
  • Pages : 544
  • ISBN 10 : 9780470119044
  • Total Read : 64
  • File Size : 16,6 Mb

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What s Wrong With My Mouse Summary:

Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters: "Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis. "Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions. The final chapter, "The Next Generation," examines new and emerging technologies. Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.

Mood and Anxiety Related Phenotypes in Mice Book

Mood and Anxiety Related Phenotypes in Mice


  • Author : Todd D Gould
  • Publisher : Humana Press
  • Release Date : 2011-09-02
  • Genre: Medical
  • Pages : 382
  • ISBN 10 : 1617793124
  • Total Read : 91
  • File Size : 19,6 Mb

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Mood and Anxiety Related Phenotypes in Mice Summary:

Preclinical research related to mood and anxiety disorders relies extensively upon mouse behavioral tests and models, the use of which continues to increase as a greater number of underlying susceptibility genes are discovered, new targets for medications are identified, and clinical studies reveal novel neurobiological risk factors. Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, Volume II serves as a complement to the previous volume in order to offer a comprehensive resource for the behavioral approaches that are valuable for the characterization of mood and anxiety disorder-related behaviors in mice and the techniques that are utilized in the development of effective medications. As a collection presented in the Neuromethods series, each chapter provides a brief background and review of the test or model as well as a complete and up-to-date protocol narrative. Authoritative and comprehensive, Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, Volume II is an ideal resource for scientists actively pursuing or interested in establishing vital behavioral protocols in their laboratories.

Animal Models of Cognitive Impairment Book

Animal Models of Cognitive Impairment


  • Author : Edward D. Levin
  • Publisher : CRC Press
  • Release Date : 2006-06-22
  • Genre: Science
  • Pages : 400
  • ISBN 10 : 9781420004335
  • Total Read : 97
  • File Size : 11,7 Mb

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Animal Models of Cognitive Impairment Summary:

The costs associated with a drug’s clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairment examines some of the most popular and successful animal archetypes used in the context of drug discovery. It provides integrated coverage of the latest research concerning neuronal systems relevant to cognitive function and dysfunction, assimilating reviews of this research within the context of each chapter. This approach is unique in that it brings together molecular and neurochemical methodologies, behavioral applications in translational models, and clinical applications. The book comprehensively discusses a wide variety of animal models of cognitive impairment, including genetic, lesion, pharmacological, and aging related impairments. It also explores the significance of this research in regards to the treatment of various addictions and disorders such as stroke, autism, Alzheimer’s, schizophrenia, and ADHD. Edited by two renowned authorities in the field, Animal Models of Cognitive Impairment is a timely book that provides integrated coverage of cutting-edge research that concerns neuronal systems relevant to cognitive function and dysfunction.

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research Book

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research


  • Author : National Research Council
  • Publisher : National Academies Press
  • Release Date : 2003-08-22
  • Genre: Science
  • Pages : 223
  • ISBN 10 : 030916785X
  • Total Read : 60
  • File Size : 15,7 Mb

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Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research Summary:

Expanding on the National Research Council’s Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal’s well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Rodent Models of Stroke Book

Rodent Models of Stroke


  • Author : Ulrich Dirnagl
  • Publisher : Humana Press
  • Release Date : 2010-07-08
  • Genre: Medical
  • Pages : 285
  • ISBN 10 : 1607617498
  • Total Read : 94
  • File Size : 18,8 Mb

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Rodent Models of Stroke Summary:

In view of the numerous failures of clinical trials aimed at improving stroke therapy, the role and potential benefit of experimentally modeling focal cerebral ischemia in rodents has been debated. When methods of systematic review and metaanalyis are applied, however, it turns out that experimental models actually faithfully predicted the negative outcomes of clinical trials. In addition, thrombolysis and neuroprotection by hypothermia, first described in animal models, are key examples of treatment modalities that have made it successfully into clinical practice. In Rodent Models of Stroke, an international consortium of authors aims at critically addressing the issues on a very practical level, from choosing the model and outcome measures, designing the experiment, conducting and analyzing it, to reporting it in a scientific publication. The structure and content of the book reflect both the authors’ longstanding expertise in experimental and clinical stroke research and their roles in training the scientific community in the tools of the trade. As a volume in the successful Neuromethods series, the chapters provide authoritative reviews of the most commonly used, well-honed approaches in the field today. Stimulating and easy-to-use, Rodent Models of Stroke will help its readers understand the limitations and the opportunities of modeling stroke in rodents and enable them to conduct experiments which will not only improve our understanding of the pathophysiology of this devastating disorder but also serve as the basis for developing new highly effective treatments.

Behavioral Genetics of the Mouse  Volume 1  Genetics of Behavioral Phenotypes Book

Behavioral Genetics of the Mouse Volume 1 Genetics of Behavioral Phenotypes


  • Author : Wim E. Crusio
  • Publisher : Cambridge University Press
  • Release Date : 2013-04-25
  • Genre: Science
  • Pages : null
  • ISBN 10 : 9781107355576
  • Total Read : 98
  • File Size : 9,6 Mb

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Behavioral Genetics of the Mouse Volume 1 Genetics of Behavioral Phenotypes Summary:

The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.