Nuclear Mechanics and Genome Regulation Book

Nuclear Mechanics and Genome Regulation


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2010-10-12
  • Genre: Science
  • Pages : 392
  • ISBN 10 : 0123810108
  • Total Read : 61
  • File Size : 8,9 Mb

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Nuclear Mechanics and Genome Regulation Summary:

In recent years new discoveries have made this an exciting and important field of research. This exhaustive volume presents comprehensive chapters and detailed background information for researchers working with in the field of nuclear mechanics and genome regulation. Both classic and state-of-the-art methods readily adaptable and designed to last the test of time Relevant to clinicians and scientists working in a wide range of fields

Introduction to Nuclear Mechanics and Genome Regulation Book

Introduction to Nuclear Mechanics and Genome Regulation


  • Author : G.V. Shivashankar
  • Publisher : Academic Press
  • Release Date : 2019-06-15
  • Genre: Medical
  • Pages : 200
  • ISBN 10 : 0128123451
  • Total Read : 90
  • File Size : 16,5 Mb

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Introduction to Nuclear Mechanics and Genome Regulation Summary:

Introduction to Nuclear Mechanics and Genome Regulation provides a detailed discussion of the biophysical principles underlying nuclear organization and their role in determining tissue function, cell differentiation and homeostasis, and disease expression and management. Applied case studies and full cover images support concept illustration across a diverse range of chapters covering physico-chemical constraints in DNA, 3D organization of chromosomes and functional gene clusters, spatial dimensions of DNA transcription, replication, damage and repair, and more. With its practical approach and foundational focus, this book will be an invaluable reference for students, researchers and clinicians looking to understand this area of cutting-edge study. Contains applied case studies and full color images that support concept illustration Features a diverse range of chapters that cover the fundamentals of nuclear mechanics and genome regulation, including physico-chemical constraints in DNA Introduces advanced biophysical methods, bio-imaging methods, and new molecular biology tools for studying nuclear structures

Genome and Disease Book

Genome and Disease


  • Author : Jean-Nicolas Volff
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2006-01-01
  • Genre: Medical
  • Pages : 255
  • ISBN 10 : 9783805580298
  • Total Read : 75
  • File Size : 10,8 Mb

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Genome and Disease Summary:

Cancer and other genetic human diseases are caused by a variety of mutations, ranging from subtle sequence changes to larger genomic rearrangements and alterations in chromosome number (aneuploidy). With contributions by reputed experts, this book aims to update the knowledge on the multiple mechanisms of genomic instability leading to human disease. Emphasis is given to the different types of genomic sequences involved in disease-related genomic rearrangements as well as to the various exogenous factors increasing the frequency of mutations. Several chapters are dedicated to the dysfunction of important cellular mechanisms like DNA repair and chromosome segregation, which may cause genomic instability and result in tumorigenesis. Important 'caretaker' genes controlling the stability of our genome have been identified through their defect in genomic instability syndromes, which are also extensively reviewed in this volume. This book provides an important update not only for investigators in biology and medicine, but also for physicians and anyone interested in the molecular basis of human disease.

Nuclear  Chromosomal  and Genomic Architecture in Biology and Medicine Book

Nuclear Chromosomal and Genomic Architecture in Biology and Medicine


  • Author : Malgorzata Kloc
  • Publisher : Springer Nature
  • Release Date : 2022-11-08
  • Genre: Science
  • Pages : 657
  • ISBN 10 : 9783031065736
  • Total Read : 94
  • File Size : 16,9 Mb

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Nuclear Chromosomal and Genomic Architecture in Biology and Medicine Summary:

This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases. The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are necessary for cell differentiation, the establishment of cell fate during development and maturation of tissues and organs including the immune, muscle, and nervous systems. The non-programmed changes in the nuclear architecture can lead to fragmentation of the nucleus and instability of the genome and thus cause cancer. Microbial and viral infections can lead to a clustering of centromeres, telomeres and ribosomal DNA and alter the properties of the nuclear membrane, allowing large immobile macromolecules to enter the nucleus. Recent advances in next-generation sequencing technologies combined with nucleus/chromosome conformation capture, super-resolution imaging, chromosomal contact maps methods, integrative modeling, and genetic approaches, are uncovering novel features and importance of nuclear, chromosomal and genomic architecture. This book is an interesting read for cell biologists, researchers studying the structure and function of chromosomes, and anyone else who wants to get an overview of the field of nuclear, chromosomal and genomic architecture.

Epigenetics  Nuclear Organization   Gene Function Book

Epigenetics Nuclear Organization Gene Function


  • Author : John C. Lucchesi
  • Publisher : Oxford University Press
  • Release Date : 2018-12-19
  • Genre: Science
  • Pages : 240
  • ISBN 10 : 9780192567161
  • Total Read : 65
  • File Size : 13,7 Mb

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Epigenetics Nuclear Organization Gene Function Summary:

Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine. This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information.

The Nuclear Envelope Book

The Nuclear Envelope


  • Author : Sue Shackleton
  • Publisher : Humana Press
  • Release Date : 2016-05-05
  • Genre: Science
  • Pages : 523
  • ISBN 10 : 1493935283
  • Total Read : 88
  • File Size : 10,5 Mb

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The Nuclear Envelope Summary:

This volume provides a wide range of protocols used in studying the nuclear envelope, with special attention to the experimental adjustments that may be required to successfully investigate this complex organelle in cells from various organisms. The Nuclear Envelope: Methods and Protocols is divided into five sections: Part I – Nuclear Envelope Isolation; Part II – Nuclear Envelope Protein Interactions, Localization, and Dynamics; Part III – Nuclear Envelope Interactions with the Cytoskeleton; Part IV – Nuclear Envelope-Chromatin Interactions; and Part V – Nucleo-Cytoplasmic Transport. Many of the modifications discussed in this book have only been circulated within laboratories that have conducted research in this field for many years. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and thorough, The Nuclear Envelope: Methods and Protocols is a timely resource for researchers who have joined this dynamic and rapidly growing field.

Anatomy of Gene Regulation Book

Anatomy of Gene Regulation


  • Author : Panagiotis A. Tsonis
  • Publisher : Cambridge University Press
  • Release Date : 2003-01-13
  • Genre: Medical
  • Pages : 300
  • ISBN 10 : 0521804744
  • Total Read : 93
  • File Size : 11,7 Mb

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Anatomy of Gene Regulation Summary:

No longer simple line drawings on a page, molecular structures can now be viewed in full-figured glory, often in color and even with interactive possibilities. Anatomy of Gene Regulation is the first book to present the parts and processes of gene regulation at the three-dimensional level. Vivid structures of nucleic acids and their companion proteins are revealed in full-color, three-dimensional form. Beginning with a general introduction to three-dimensional structures, the book looks at the organization of the genome, the structure of DNA, DNA replication and transcription, splicing, protein synthesis, and ultimate protein death. Throughout, the text employs a discussion of genetics and structural mechanics. The concise and unique synthesis of information will offer insight into gene regulation, and into the development of methods to interfere with regulation at diseased states. This textbook and its accompanying web site are appropriate for both undergraduate and graduate students in genetics, molecular biology, structural biology, and biochemistry courses.

The Cell  A Very Short Introduction Book

The Cell A Very Short Introduction


  • Author : Terence Allen
  • Publisher : OUP Oxford
  • Release Date : 2011-09-29
  • Genre: Science
  • Pages : 160
  • ISBN 10 : 9780191620263
  • Total Read : 74
  • File Size : 5,6 Mb

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The Cell A Very Short Introduction Summary:

All living things on Earth are composed of cells. A cell is the simplest unit of a self-contained living organism, and the vast majority of life on Earth consists of single-celled microbes, mostly bacteria. These consist of a simple 'prokaryotic' cell, with no nucleus. The bodies of more complex plants and animals consist of billions of 'eukaryotic' cells, of varying kinds, adapted to fill different roles - red blood cells, muscle cells, branched neurons. Each cell is an astonishingly complex chemical factory, the activities of which we have only begun to unravel in the past fifty years or so through modern techniques of microscopy, biochemistry, and molecular biology. In this Very Short Introduction, Terence Allen and Graham Cowling describe the nature of cells - their basic structure, their varying forms, their division, their differentiation from initially highly flexible stem cells, their signalling, and programmed death. Cells are the basic constituent of life, and understanding cells and how they work is central to all biology and medicine. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.