Inhaled Medicines Book

Inhaled Medicines


  • Author : Stavros Kassinos
  • Publisher : Academic Press
  • Release Date : 2021-02-05
  • Genre: Business & Economics
  • Pages : 438
  • ISBN 10 : 9780128149744
  • Total Read : 94
  • File Size : 6,8 Mb

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Inhaled Medicines Summary:

Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments. ? Considers the healthcare needs driving the field, and where inhaled drugs could have the maximum impact ? Gives a concise account of the state of the art in key areas and technologies such as device and formulation technologies, clinically relevant in vitro performance assessment, medical imaging, as well as in silico modelling and simulation ? Articulates how the combination of in vitro product performance data, medical imaging and simulations technologies in the framework of large scale in silico pre-clinical trials could revolutionize the field ? Provides systematic and thorough referencing to sources of

Inhaled Medicines Book

Inhaled Medicines


  • Author : Stavros Kassinos
  • Publisher : Academic Press
  • Release Date : 2021-01-20
  • Genre: Business & Economics
  • Pages : 438
  • ISBN 10 : 9780128149751
  • Total Read : 78
  • File Size : 9,5 Mb

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Inhaled Medicines Summary:

Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments. ● Considers the healthcare needs driving the field, and where inhaled drugs could have the maximum impact ● Gives a concise account of the state of the art in key areas and technologies such as device and formulation technologies, clinically relevant in vitro performance assessment, medical imaging, as well as in silico modelling and simulation ● Articulates how the combination of in vitro product performance data, medical imaging and simulations technologies in the framework of large scale in silico pre-clinical trials could revolutionize the field ● Provides systematic and thorough referencing to so

The Mechanics of Inhaled Pharmaceutical Aerosols Book

The Mechanics of Inhaled Pharmaceutical Aerosols


  • Author : Warren H. Finlay
  • Publisher : Academic Press
  • Release Date : 2019-06-01
  • Genre: Technology & Engineering
  • Pages : 302
  • ISBN 10 : 9780081027868
  • Total Read : 90
  • File Size : 8,8 Mb

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The Mechanics of Inhaled Pharmaceutical Aerosols Summary:

The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction, Second Edition provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols. This revised edition will allow researchers in the field to gain a thorough understanding of the field from first principles, allowing them to understand, design, develop and improve inhaled pharmaceutical aerosol devices and therapies. Chapters consider mechanics and deposition, specifically in the respiratory tract, while others discuss the mechanics associated with the three existing types of pharmaceutical inhalation devices. This text will be very useful for academics and for courses taught at both undergraduate and graduate levels. Because of the interdisciplinary nature of this book, it will also serve a wide audience that includes engineers and scientists involved with inhaled aerosol therapies. Provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols Allows researchers in the field to gain an up-to-date, thorough understanding of the field from first principles Introduces the pharmaceutical aerosols field to the many engineers and scientists entering the area

Inhaled Pharmaceutical Product Development Perspectives Book

Inhaled Pharmaceutical Product Development Perspectives


  • Author : Anthony J. Hickey
  • Publisher : Elsevier
  • Release Date : 2017-09
  • Genre: Uncategoriezed
  • Pages : 150
  • ISBN 10 : 0128122099
  • Total Read : 94
  • File Size : 15,9 Mb

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Inhaled Pharmaceutical Product Development Perspectives Summary:

Inhaled Pharmaceutical Product Development Perspectives describes methods and protocols for developing inhaled pharmaceuticals while commenting on product development strategies and their suitability to support regulatory submission. It fills the gap between the aspirations of scientists invested in new technology development and the reality of the requirements that must be met for any new product to be commercialized. The book brings together emerging analytical and inhalation technologies in a way that provides a unique perspective on formulation and device design, development, regulatory compliance and practice. Focusing on underlying scientific and technical principles known to be acceptable from the current regulatory perspective, this monograph will remain useful as a high-level guide to inhaled product development for the foreseeable future. Focuses on underlying scientific and technical principles known to be acceptable from the current regulatory perspective Discusses development strategies and best practices to support regulatory submissions Written by an experienced expert and draws on the knowledge and critical opinions of key individuals in the field Brings together emerging analytical and inhalation technologies

Inhalation Aerosols Book

Inhalation Aerosols


  • Author : Anthony J. Hickey
  • Publisher : CRC Press
  • Release Date : 2019-03-21
  • Genre: Medical
  • Pages : 546
  • ISBN 10 : 9781351660518
  • Total Read : 79
  • File Size : 18,9 Mb

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Inhalation Aerosols Summary:

Inhalation aerosols continue to be the basis for successful lung therapy for several diseases, with therapeutic strategies and the range of technology significantly evolving in recent years. In response, this third edition takes a new approach to reflect the close integration of technology with its application. After briefly presenting the general considerations that apply to aerosol inhalation, the central section of the book uses the focus on disease and therapeutic agents to illustrate the application of specific technologies. The final integrated strategies section draws the major points from the applications for disease targets and drug products.

Inhaler Devices Book

Inhaler Devices


  • Author : Polina Prokopovich
  • Publisher : Elsevier
  • Release Date : 2013-04-23
  • Genre: Technology & Engineering
  • Pages : 192
  • ISBN 10 : 9780857098696
  • Total Read : 64
  • File Size : 8,9 Mb

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Inhaler Devices Summary:

Given their direct impact on the health and quality of life for millions, inhalers represent a major turning point in the history of modern medicine. Inhaler devices: Fundamentals, design and drug delivery provides readers with an introduction to the fundamentals of inhaler technology, with a comprehensive discussion of the history of inhalers as well as a discussion on current research and development. Part one discusses the fundamentals and development of inhaler devices as well as drug formulations for inhalers. The treatment of asthma is also discussed. Part two reviews recent developments in drug formulation and nanotechnology for inhaler devices, emerging inhaler technology and possible future trends. Inhaler devices: Fundamentals, design and drug delivery is an essential design guide for good industrial practice, and will be an invaluable resource for those researching and treating conditions such as asthma; and those developing and manufacturing inhalation devices. Introduces the fundamentals of inhaler technology Discusses the history of inhalers as well as current research and development as well as possible future trends Considers the development of inhaler devices, drug formulations and discusses the treatment of asthma

Pharmaceutical Inhalation Aerosol Technology  Third Edition Book

Pharmaceutical Inhalation Aerosol Technology Third Edition


  • Author : Anthony J. Hickey
  • Publisher : CRC Press
  • Release Date : 2019-03-26
  • Genre: Medical
  • Pages : 784
  • ISBN 10 : 9780429619564
  • Total Read : 90
  • File Size : 16,9 Mb

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Pharmaceutical Inhalation Aerosol Technology Third Edition Summary:

This fully revised and updated third edition of Pharmaceutical Inhalation Aerosol Technology encompasses the scientific and technical foundation for the rationale, design, componentry, assembly and quality performance metrics of therapeutic inhalers in their delivery of pharmaceutical aerosols to treat symptoms or the underlying causes of disease. It focuses on the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery. The expanded scope considers previously unaddressed aspects of pharmaceutical inhalation aerosol technology and the patient interface by including aerosol delivery, lung deposition and clearance that are used as measures of effective dose delivery. Key Features: Provides a thoroughly revised and expanded reference with authoritative discussions on the physiologic,pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosols Emphasizes the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery Addresses the physics, chemistry and engineering principles while establishing disease relevance Expands the ‘technology’ focus of the original volumes to address the title more directly Offers an impressive breadth of coverage as well as an international flavour from outstanding editors and contributors

The Mechanics of Inhaled Pharmaceutical Aerosols Book

The Mechanics of Inhaled Pharmaceutical Aerosols


  • Author : Warren H. Finlay
  • Publisher : Academic Press
  • Release Date : 2001-07-06
  • Genre: Medical
  • Pages : 328
  • ISBN 10 : 0122569717
  • Total Read : 69
  • File Size : 12,6 Mb

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The Mechanics of Inhaled Pharmaceutical Aerosols Summary:

The Mechanics of Inhaled Pharmaceutical Aerosols, An Introduction provides a unique and comprehensive treatment of the mechanics of inhaled pharmaceutical aerosols. The book covers a wide range of topics and many new perspectives are given by drawing on research from a variety of fields. Novel, in-depth expositions of the most common delivery devices are given, including nebulizers, dry powder inhalers and propellant metered dose inhalers. The behaviour of aerosols in the respiratory tract is explained in detail, with complete coverage of the fundamentals of current deposition models. The book begins by providing a comprehensive introduction to aspects of aerosol mechanics that are relevant to inhaled pharmaceutical aerosols. It then gives an exhaustive pedagogical description of the behaviour of evaporating and condensing droplets (both aqueous and propellant-based), an introductory chapter on lung geometry and inhalation patterns, and coverage of relevant aspects of fluid mechanics in the lung. Finally, the book provides invaluable, detailed coverage on the mechanics of common pharmaceutical aerosol delivery systems and deposition in the respiratory tract. Throughout the book are many detailed numerical examples that apply the salient concepts to typical inhaled pharmaceutical aerosols. This book will be of interest to scientists and engineers involved in the research and development of inhaled pharmaceutical aerosol products. Experienced practitioners will find many new perspectives that will greatly enhance their understanding of this complex and rapidly growing field. For those delivering therapeutic agents to the lung, this book is a must-have. Students and academics will find this book an invaluable tool and for newcomers it is a worthy guide to the diverse fields that must be understood to work in the area of inhaled pharmaceutical aerosols.