Improving the Therapeutic Ratio in Head and Neck Cancer Book

Improving the Therapeutic Ratio in Head and Neck Cancer


  • Author : Randall J. Kimple
  • Publisher : Academic Press
  • Release Date : 2020-01-06
  • Genre: Science
  • Pages : 300
  • ISBN 10 : 012817868X
  • Total Read : 65
  • File Size : 12,6 Mb

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Improving the Therapeutic Ratio in Head and Neck Cancer Summary:

Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites. Provides key scientific background for clinicians when developing novel clinical trials and important examples for basic scientists of the types of work required to move a concept from the lab to the clinic Presents consistent pathway diagrams in each chapter, thus making it easier to understand complicated pathways Includes chapter summaries of the critical next steps needed to move studies from their current state into practice changing clinical data

Improving the Therapeutic Ratio in Head and Neck Cancer Book

Improving the Therapeutic Ratio in Head and Neck Cancer


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-10-04
  • Genre: Science
  • Pages : 376
  • ISBN 10 : 9780128178690
  • Total Read : 69
  • File Size : 7,8 Mb

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Improving the Therapeutic Ratio in Head and Neck Cancer Summary:

Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites. Provides key scientific background for clinicians when developing novel clinical trials and important examples for basic scientists of the types of work required to move a concept from the lab to the clinic Presents consistent pathway diagrams in each chapter, thus making it easier to understand complicated pathways Includes chapter summaries of the critical next steps needed to move studies from their current state into practice changing clinical data

Molecular Targeted Radiosensitizers Book

Molecular Targeted Radiosensitizers


  • Author : Henning Willers
  • Publisher : Springer Nature
  • Release Date : 2020-08-10
  • Genre: Medical
  • Pages : 364
  • ISBN 10 : 9783030497019
  • Total Read : 66
  • File Size : 8,6 Mb

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Molecular Targeted Radiosensitizers Summary:

Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.

Novel Therapies in Head and Neck Cancer  Beyond the Horizon Book

Novel Therapies in Head and Neck Cancer Beyond the Horizon


  • Author : Maie A. St. John
  • Publisher : Academic Press
  • Release Date : 2020-06-29
  • Genre: Science
  • Pages : 266
  • ISBN 10 : 9780128209295
  • Total Read : 66
  • File Size : 8,9 Mb

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Novel Therapies in Head and Neck Cancer Beyond the Horizon Summary:

Novel Therapies in Head and Neck Cancer: Beyond the Horizon, Volume Twelve, provides a high-level synthesis of the latest treatments and outcomes relating to head and neck cancer. Chemotherapy and immunotherapy for those cancer types are rapidly evolving, and an updated source based on the expertise of internationally renowned researchers is necessary. This book discusses the outcome of recent trials using chemotherapy, novel approaches for HPV+ SCCA, cases in which immunotherapy is more likely to be successful, and precision medicine based on target therapies. Additionally, new approaches for rare diseases in head and neck and novel drug delivery platforms are presented. This book will be a very useful source so that students, scientists and clinicians who can be facile with the data, build on what is known, and continue to offer cutting-edge, validated therapies to all patients. Covers new chemotherapy trials, specifically on HPV and non-HPV related cancer types Discusses the application of immunotherapy to treat rare types of head and neck cancer Presents updated information on targeted therapies, specifically focusing on skin cancer in the region

High Risk Cutaneous Squamous Cell Carcinoma Book

High Risk Cutaneous Squamous Cell Carcinoma


  • Author : Chrysalyne D. Schmults
  • Publisher : Springer
  • Release Date : 2016-04-29
  • Genre: Medical
  • Pages : 255
  • ISBN 10 : 9783662470817
  • Total Read : 95
  • File Size : 18,6 Mb

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High Risk Cutaneous Squamous Cell Carcinoma Summary:

This book is a cutting-edge resource that provides clinicians with the up-to-date practical knowledge required in order to manage SCC patients optimally. It summarizes newly available information relating to the definition of high-risk SCC, its pathophysiologic underpinnings, and its management. New prognostic information and staging systems are summarized that enable high-risk tumors to be defined more precisely than ever before. Many helpful tips are provided on the practical management of challenging cases, including multiple tumors/field cancerization, high-risk tumors, nodal metastases, and unresectable disease. The authors are all acknowledged experts in the emerging field of high-risk and advanced SCC.​

Metronomic Chemotherapy Book

Metronomic Chemotherapy


  • Author : Guido Bocci
  • Publisher : Springer
  • Release Date : 2014-09-04
  • Genre: Medical
  • Pages : 295
  • ISBN 10 : 9783662436042
  • Total Read : 74
  • File Size : 16,7 Mb

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Metronomic Chemotherapy Summary:

This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.

Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment Book

Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment


  • Author : Mitchell S. Anscher
  • Publisher : Springer
  • Release Date : 2016-10-20
  • Genre: Medical
  • Pages : 305
  • ISBN 10 : 9783319455945
  • Total Read : 60
  • File Size : 15,5 Mb

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Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment Summary:

This volume will describe recent progress and future directions in radiation oncology and biology research, focusing on strategies designed to improve disease control and reduce the risk of long-term adverse effects on patients. As more and more patients are becoming long-term survivors, this strategy will become increasingly important--in radiation oncology and throughout the field of oncology.