Hyaluronan in Cancer Biology Book

Hyaluronan in Cancer Biology


  • Author : Robert Stern
  • Publisher : Academic Press
  • Release Date : 2009-03-07
  • Genre: Medical
  • Pages : 468
  • ISBN 10 : 0080921086
  • Total Read : 97
  • File Size : 10,7 Mb

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Hyaluronan in Cancer Biology Summary:

Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal. The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book will offer a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer. * Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer * Chapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and dissemination * Focuses on understanding the mechanisms that drive tumor cell activation, proliferation, and drug resistance

Chemistry and Biology of Hyaluronan Book
Score: 4
From 1 Ratings

Chemistry and Biology of Hyaluronan


  • Author : Hari G. Garg
  • Publisher : Elsevier
  • Release Date : 2004-07-14
  • Genre: Science
  • Pages : 624
  • ISBN 10 : 0080472222
  • Total Read : 88
  • File Size : 17,6 Mb

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Chemistry and Biology of Hyaluronan Summary:

It was probably the French chemist Portes, who first reported in 1880 that the mucin in the vitreous body, which he named hyalomucine, behaved differently from other mucoids in cornea and cartilage. Fifty four years later Karl Meyer isolated a new polysaccharide from the vitreous, which he named hyaluronic acid. Today its official name is hyaluronan, and modern-day research on this polysaccharide continues to grow. Expertly written by leading scientists in the field, this book provides readers with a broad, yet detailed review of the chemistry of hyaluronan, and the role it plays in human biology and pathology. Twenty-seven chapters present a sequence leading from the chemistry and biochemistry of hyaluronan, followed by its role in various pathological conditions, to modified hylauronans as potential therapeutic agents and finally to the functional, structural and biological properties of hyaluronidases. Chemistry and Biology of Hyaluronan covers the many interesting facets of this fascinating molecule, and all chapters are intended to reach the wider research community. Comprehensive look at the chemistry and biology of hyaluronans Essential to Chemists, Biochemists and Medical researchers Broad yet detailed review of this rapidly growing research area

Molecular Regulation of Endocytosis Book

Molecular Regulation of Endocytosis


  • Author : Brian Ceresa
  • Publisher : BoD – Books on Demand
  • Release Date : 2012-07-06
  • Genre: Science
  • Pages : 470
  • ISBN 10 : 9789535106623
  • Total Read : 60
  • File Size : 20,6 Mb

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Molecular Regulation of Endocytosis Summary:

Molecular Regulation of Endocytosis is a compilation of scientific "short stories" about the entry of external substances into cells. As one can see from the chapters, endocytosis regulates diverse processes such as homeostasis of the cell, signal transduction, entry of pathogens and viruses. In addition to the experimental techniques embedded in each chapter, entire chapters are dedicated to experimental approaches that will be useful to all scientists and their model systems. For those more clinically oriented, the final chapters look to the future and ways of utilizing endocytic pathways for therapeutic purposes.

Interaction between Hyaluronic Acid and Its Receptors  CD44  RHAMM  Regulates the Activity of Inflammation and Cancer Book

Interaction between Hyaluronic Acid and Its Receptors CD44 RHAMM Regulates the Activity of Inflammation and Cancer


  • Author : David Naor
  • Publisher : Frontiers Media SA
  • Release Date : 2016-07-18
  • Genre: Immunologic diseases. Allergy
  • Pages : 220
  • ISBN 10 : 9782889199136
  • Total Read : 62
  • File Size : 15,7 Mb

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Interaction between Hyaluronic Acid and Its Receptors CD44 RHAMM Regulates the Activity of Inflammation and Cancer Summary:

The biological outcome of Hyaluronan (also hyaluronic acid, abbreviated HA) interaction with its CD44 or RHAMM receptors recently attracted much attention within the scientific community owing to a Nature article by Tian X et al. (Nature 2013; 499:346-9). The article described a life span exceeding 30 years in naked mole rats, whereas the maximal lifespan of mice, to which the naked mole rat is related, is only 4 years. This observation is accompanied by the finding that the naked mole rat, in contrast to the mouse, does not develop spontaneous tumors during this exceptional longevity. The article provides evidence that interaction of long tissue HA (6000-12,000 kDa) of the naked mole rat with cell surface CD44, in contrast to the interaction of short tissue HA (less than 3000 kDa) with the mouse CD44, makes the difference. More specifically, this communication shows that the interaction of short HA with fibroblasts’ CD44 imposes on them susceptibility for malignant transformation, whereas the corresponding interaction with long HA imposes on the fibroblasts a resistance to malignant transformation. The article does not explain the mechanism that underlines these findings. However, the articles, that will be published in the proposed Research Topic in the Inflammation section of Frontiers in Immunology, can bridge not only this gap, but also may explain why interaction between short HA and cell surface CD44 (or RHAMM, an additional HA receptor) enhances the development of inflammatory and malignant diseases. Furthermore, the articles included in the proposed Frontiers Research Topic will show that cancer cells and inflammatory cells share several properties related to the interaction between short HA and cell surface CD44 and/or RHAMM. These shared properties include: 1. Support of cell migration, which allows tumor metastasis and accumulation of inflammatory cells at the inflammation site; 2. Delivery of intracellular signaling, which leads to cell survival of ei

Tumor Microenvironment Book

Tumor Microenvironment


  • Author : Alexander Birbrair
  • Publisher : Springer Nature
  • Release Date : 2020-04-07
  • Genre: Medical
  • Pages : 181
  • ISBN 10 : 9783030401467
  • Total Read : 79
  • File Size : 6,5 Mb

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Tumor Microenvironment Summary:

Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor during cancer development. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include heparan sulphate, hyaluronan, fibronectin, perlecan, glypican, matrix metalloproteinases, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components – Part A updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newest generation of researchers, this volume serves as a useful introduction to the history of scientists’ focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book is an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research. All of the chapter authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters.

Hyaluronic Acid Book

Hyaluronic Acid


  • Author : V. N. Khabarov
  • Publisher : John Wiley & Sons
  • Release Date : 2014-12-22
  • Genre: Science
  • Pages : 216
  • ISBN 10 : 9781118695951
  • Total Read : 69
  • File Size : 13,5 Mb

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Hyaluronic Acid Summary:

Hyaluronic acid is an essential part of connective, epithelialand neural tissues, and contributes to cell proliferation andmigration. It is used as a stimulating agent for collagen synthesisand is a common ingredient in skin-care products, a multi-billiondollar industry, as it is believed to be a key factor in fightingthe aging process. Hyaluronic Acid: Production, Properties, Application inBiology and Medicine consists of six chapters discussing thevarious issues of hyaluronic acid research. In Chapter 1, ahistorical analysis recounts the discovery and milestones of theresearch leading to the practical applications of hyaluronan.Chapter 2 is dedicated to biological role of the hyaluronic acid innature, in particular in the human body. The chapter starts fromthe phylogenesis of hyaluronic acid, then describes hyaluronanfunctions in human ontogenesis and especially the role whichhyaluronan plays in extracellular matrix of the different tissues.Chapter 3 describes the methods to manufacture and purifyhyaluronic acid, including the analytical means for assessingquality of the finished product. Chapter 4 discusses the structureand rheological properties of hyaluronic acid considering effectson conformation and biological properties related to molecularweight. In Chapter 5, the physical and chemical methods formodifying the structure of hyaluronan are discussed includingcross-linking using bi-functional reagents, solid-phasemodification and effects of the combined action of high pressuresand shift deformation. The final chapter focuses on the productsderived from hyaluronic acid, including therapeutics composed ofmodified hyaluronan conjugated to vitamins, amino acids andoligo-peptides. The biological roles and medical applications ofthis polysaccharide have been extensively studied and this bookprovides a wealth of scientific data demonstrating the criticalrole of hyaluronic acid and its promise as a multifacetedbio-macromolecule. Approaching hyaluronic acid from multip

Essentials of Glycobiology Book
Score: 4
From 1 Ratings

Essentials of Glycobiology


  • Author : Ajit Varki
  • Publisher : CSHL Press
  • Release Date : 1999
  • Genre: Science
  • Pages : 694
  • ISBN 10 : 0879696818
  • Total Read : 83
  • File Size : 18,7 Mb

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Essentials of Glycobiology Summary:

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Hyaluronan Signaling and Turnover Book

Hyaluronan Signaling and Turnover


  • Author : Melanie Simpson
  • Publisher : Academic Press
  • Release Date : 2014-07-26
  • Genre: Medical
  • Pages : 418
  • ISBN 10 : 9780128003930
  • Total Read : 76
  • File Size : 12,7 Mb

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Hyaluronan Signaling and Turnover Summary:

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. This volume covers hyaluronan signaling and turnover. Provides information on cancer research Outstanding and original reviews Suitable for researchers and students