High Throughput Bioanalytical Sample Preparation Book

High Throughput Bioanalytical Sample Preparation


  • Author : David A. Wells
  • Publisher : Elsevier Science Limited
  • Release Date : 2003-01-28
  • Genre: Science
  • Pages : 648
  • ISBN 10 : UOM:39015056471918
  • Total Read : 73
  • File Size : 12,5 Mb

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High Throughput Bioanalytical Sample Preparation Summary:

High Throughput Bioanalytical Sample Preparation: Methods and Automation Strategies is an authoritative reference on the current state-of-the-art in sample preparation techniques for bioanalysis. This book focuses on high throughput (rapid productivity) techniques and describes exactly how to perform and automate these methodologies, including useful strategies for method development and optimization. A thorough review of the literature is included within each of these chapters describing high throughput sample preparation techniques: protein removal by precipitation; equilibrium dialysis and ultrafiltration; liquid-liquid extraction; solid-phase extraction; and various on-line techniques. The text begins with an introductory overview of the role of bioanalysis in pharmaceutical drug development. Fundamental understanding of the strategies for sample preparation is reinforced next, along with essential concepts in extraction chemistry. Several chapters introduce and discuss microplates, accessory products and automation devices. Particular strategies for efficient use of automation within a bioanalytical laboratory are also presented. The subject material then reviews protein precipitation, liquid-liquid extraction, solid-phase extraction and various on-line sample preparation approaches. The book concludes with information on recent advances in sample preparation, such as solid-phase extraction in a card format and higher density extraction plates. Important objectives that can be accomplished when the strategies presented in this book are followed include: improved efficiency in moving discovery compounds to preclinical status with robust analytical methods; return on investment in automation for sample preparation; and improved knowledge and expertise of laboratory staff. · Shows the reader exactly how to perform modern bioanalytical sample preparation techniques, complete with detailed strategies · Thorough literature review and summary of published informatio

Applied Biological Engineering Book

Applied Biological Engineering


  • Author : Ganesh R. Naik
  • Publisher : BoD – Books on Demand
  • Release Date : 2012-03-23
  • Genre: Medical
  • Pages : 676
  • ISBN 10 : 9789535104124
  • Total Read : 86
  • File Size : 16,6 Mb

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Applied Biological Engineering Summary:

Biological engineering is a field of engineering in which the emphasis is on life and life-sustaining systems. Biological engineering is an emerging discipline that encompasses engineering theory and practice connected to and derived from the science of biology. The most important trend in biological engineering is the dynamic range of scales at which biotechnology is now able to integrate with biological processes. An explosion in micro/nanoscale technology is allowing the manufacture of nanoparticles for drug delivery into cells, miniaturized implantable microsensors for medical diagnostics, and micro-engineered robots for on-board tissue repairs. This book aims to provide an updated overview of the recent developments in biological engineering from diverse aspects and various applications in clinical and experimental research.

High Throughput Analysis in the Pharmaceutical Industry Book

High Throughput Analysis in the Pharmaceutical Industry


  • Author : Perry G. Wang
  • Publisher : CRC Press
  • Release Date : 2008-08-20
  • Genre: Medical
  • Pages : 432
  • ISBN 10 : 9781420059540
  • Total Read : 61
  • File Size : 12,5 Mb

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High Throughput Analysis in the Pharmaceutical Industry Summary:

The introduction of combinatorial chemistry technology has increased the amount of compounds generated in a year from 50 to 2000. Conventional analytical approaches simply cannot keep up. These circumstances have caused drug discovery to take on the shape of a bottleneck, like traffic through a toll booth. In order to break the bottleneck, a corres

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics Book

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics


  • Author : Nader Rifai
  • Publisher : Elsevier Health Sciences
  • Release Date : 2017-01-16
  • Genre: Medical
  • Pages : 1888
  • ISBN 10 : 9780323548489
  • Total Read : 75
  • File Size : 5,9 Mb

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Tietz Textbook of Clinical Chemistry and Molecular Diagnostics Summary:

The Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition provides the most current and authoritative guidance on selecting, performing, and evaluating the results of new and established laboratory tests. This classic clinical chemistry reference offers encyclopedic coverage detailing everything you need to know, including: analytical criteria for the medical usefulness of laboratory tests, variables that affect tests and results, laboratory medicine, applications of statistical methods, and most importantly clinical utility and interpretation of laboratory tests. It is THE definitive reference in clinical chemistry and molecular diagnostics, now fully searchable and with quarterly content updates, podcasts, clinical cases, animations, and extended content online through Expert Consult. Analytical criteria focus on the medical usefulness of laboratory procedures. Reference ranges show new approaches for establishing these ranges — and provide the latest information on this topic. Lab management and costs gives students and chemists the practical information they need to assess costs, allowing them to do their job more efficiently and effectively. Statistical methods coverage provides you with information critical to the practice of clinical chemistry. Internationally recognized chapter authors are considered among the best in their field. Two-color design highlights important features, illustrations, and content to help you find information easier and faster. NEW! Internationally recognized chapter authors are considered among the best in their field. NEW! Expert Consult features fully searchable text, quarterly content updates, clinical case studies, animations, podcasts, atlases, biochemical calculations, multiple-choice questions, links to Medline, an image collection, and audio interviews. You will now enjoy an online version making utility of this book even greater. UPDATED! Expanded Molecular Diagnostics section with 12 chapters that fo

Tietz Textbook of Laboratory Medicine   E Book Book

Tietz Textbook of Laboratory Medicine E Book


  • Author : Nader Rifai
  • Publisher : Elsevier Health Sciences
  • Release Date : 2022-02-03
  • Genre: Medical
  • Pages : 1584
  • ISBN 10 : 9780323834674
  • Total Read : 61
  • File Size : 15,8 Mb

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Tietz Textbook of Laboratory Medicine E Book Summary:

Use THE definitive reference for laboratory medicine and clinical pathology! Tietz Textbook of Laboratory Medicine, 7th Edition provides the guidance necessary to select, perform, and evaluate the results of new and established laboratory tests. Comprehensive coverage includes the latest advances in topics such as clinical chemistry, genetic metabolic disorders, molecular diagnostics, hematology and coagulation, clinical microbiology, transfusion medicine, and clinical immunology. From a team of expert contributors led by Nader Rifai, this reference includes access to wide-ranging online resources on Expert Consult — featuring the comprehensive product with fully searchable text, regular content updates, animations, podcasts, over 1300 clinical case studies, lecture series, and more. Authoritative, current content helps you perform tests in a cost-effective, timely, and efficient manner; provides expertise in managing clinical laboratory needs; and shows how to be responsive to an ever-changing environment. Current guidelines help you select, perform, and evaluate the results of new and established laboratory tests. Expert, internationally recognized chapter authors present guidelines representing different practices and points of view. Analytical criteria focus on the medical usefulness of laboratory procedures. Use of standard and international units of measure makes this text appropriate for any user, anywhere in the world. Expert Consult provides the entire text as a fully searchable eBook, and includes regular content updates, animations, podcasts, more than 1300 clinical case studies, over 2500 multiple-choice questions, a lecture series, and more. NEW! 19 additional chapters highlight various specialties throughout laboratory medicine. NEW! Updated, peer-reviewed content provides the most current information possible. NEW! The largest-ever compilation of clinical cases in laboratory medicine is included on Expert Consult. NEW! Over 100 adaptive learning cou

Sample Preparation in LC MS Bioanalysis Book

Sample Preparation in LC MS Bioanalysis


  • Author : Wenkui Li
  • Publisher : John Wiley & Sons
  • Release Date : 2019-02-25
  • Genre: Science
  • Pages : 384
  • ISBN 10 : 9781119274322
  • Total Read : 81
  • File Size : 9,6 Mb

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Sample Preparation in LC MS Bioanalysis Summary:

Revised and Expanded Handbook Provides Comprehensive Introduction and Complete Instruction for Sample Preparation in Vital Category of Bioanalysis Following in the footsteps of the previously published Handbook of LC-MS Bioanalysis, this book is a thorough and timely guide to all important sample preparation techniques used for quantitative Liquid Chromatography–Mass Spectrometry (LC-MS) bioanalysis of small and large molecules. LC-MS bioanalysis is a key element of pharmaceutical research and development, post-approval therapeutic drug monitoring, and many other studies used in human healthcare. While advances are continually being made in key aspects of LC-MS bioanalysis such as sensitivity and throughput, the value of research/study mentioned above is still heavily dependent on the availability of high-quality data, for which sample preparation plays the critical role. Thus, this text provides researchers in industry, academia, and regulatory agencies with detailed sample preparation techniques and step-by-step protocols on proper extraction of various analyte(s) of interest from biological samples for LC-MS quantification, in accordance with current health authority regulations and industry best practices. The three sections of the book with a total of 26 chapters cover topics that include: Current basic sample preparation techniques (e.g., protein precipitation, liquid-liquid extraction, solid-phase extraction, salting-out assisted liquid-liquid extraction, ultracentrifugation and ultrafiltration, microsampling, sample extraction via electromembranes) Sample preparation techniques for uncommon biological matrices (e.g., tissues, hair, skin, nails, bones, mononuclear cells, cerebrospinal fluid, aqueous humor) Crucial aspects of LC-MS bioanalytical method development (e.g., pre-analytical considerations, derivation strategies, stability, non-specific binding) in addition to sample preparation techniques for challenging molecules (e.g., lipids, peptides, protein

Regulated Bioanalytical Laboratories Book

Regulated Bioanalytical Laboratories


  • Author : Michael Zhou
  • Publisher : John Wiley & Sons
  • Release Date : 2011-03-31
  • Genre: Science
  • Pages : 528
  • ISBN 10 : 047092280X
  • Total Read : 68
  • File Size : 16,8 Mb

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Regulated Bioanalytical Laboratories Summary:

This book provides useful information for bioanalytical / analytical scientists, analysts, quality assurance managers, and all personnel in bioanalytical laboratories through all aspects of bioanalytical technical and regulatory perspectives within bioanalytical operations and processes. Readers learn how to develop and implement strategies for routine, non-routine, and standard bioanalytical methods and on the entire equipment hardware and software qualification process. The book also gives guidelines on qualification of certified standards and in-house reference material as well as on people qualification. Finally, it guides readers through stressless internal and third party laboratory audits and inspections. It takes account to most national and international regulations and quality and accreditation standards, along with corresponding interpretation and inspection guides. The author elaborates on highly comprehensive content, making it easy not only to learn the subject but also to quickly implement the recommendations.

Sample Preparation for Hyphenated Analytical Techniques Book

Sample Preparation for Hyphenated Analytical Techniques


  • Author : Jack Rosenfeld
  • Publisher : John Wiley & Sons
  • Release Date : 2009-02-12
  • Genre: Science
  • Pages : 240
  • ISBN 10 : 9781405148030
  • Total Read : 92
  • File Size : 18,8 Mb

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Sample Preparation for Hyphenated Analytical Techniques Summary:

Linking “standard” but often mutually incompatible analytical techniques – so called hyphenation – generally leads to enhanced analytical performance, so hyphenated techniques are widely used in areas where samples are presented in complex matrices, eg environmental, pharmaceutical and biochemical analysis. With these hyphenated techniques, sample preparation is often the most time-consuming step in analysis, particularly where compounds are present in low concentration, and it has a huge influence on the quality of the analytical results. Sample preparation is still not given the importance it deserves, however. The purpose of this book is to demonstrate the sample preparation chemistry that has enabled the present sensitivity, specificity and high throughput available across a range of hyphenated analytical techniques, and to illustrate the successful utilization of existing sample preparation methodologies in various analytical applications. It identifies the problems in biology, environmental science and pharmaceutical chemistry that require new ideas in chemistry and provides considered opinion on those newer techniques that may address these problems. By dealing with wider issues than is generally found in review papers, this book will provide analytical chemists with insights that are not available by searching the literature for papers on a specific topic.