Chimeric Antigen Receptor T Cell Therapies for Cancer E Book Book

Chimeric Antigen Receptor T Cell Therapies for Cancer E Book


  • Author : Daniel W. Lee
  • Publisher : Elsevier Health Sciences
  • Release Date : 2019-11-30
  • Genre: Medical
  • Pages : 244
  • ISBN 10 : 9780323755979
  • Total Read : 89
  • File Size : 20,7 Mb

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Chimeric Antigen Receptor T Cell Therapies for Cancer E Book Summary:

From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area. Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy.

Basics of Chimeric Antigen Receptor  CAR  Immunotherapy Book

Basics of Chimeric Antigen Receptor CAR Immunotherapy


  • Author : Mumtaz Y. Balkhi
  • Publisher : Academic Press
  • Release Date : 2019-07-31
  • Genre: Medical
  • Pages : 92
  • ISBN 10 : 9780128197479
  • Total Read : 59
  • File Size : 12,7 Mb

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Basics of Chimeric Antigen Receptor CAR Immunotherapy Summary:

Basics of Chimeric Antigen Receptor (CAR) Immunotherapy presents the latest on how T cell adoptive immunotherapy has progressed in its ultimate goal of curing metastatic malignant cancers. Recent clinical data obtained with checkpoint receptor blockade inhibitors and chimeric antigen receptor (CAR) therapy has been especially promising, thus generating renewed hope that we may be on the verge of finally curing cancer. Over the years, huge progress has been made in controlling several stage IV metastasized cancers through the clinical application of checkpoint receptor inhibitory drugs and CAR-Therapy that has seen unprecedented interest in the immunotherapy field. Presents the first book to provide a basic understanding of chimeric antigen receptor (CARs) design, production and clinical application protocols Provides unique authority as the editor has worked directly with CARs Discusses the challenges encountered in actual clinical trials and how these challenges can be overcome Includes a full chapter on various challenges researchers should expect to encounter in the CAR-therapy field

Chimeric Antigen Receptor T Cell Therapies for Cancer Book

Chimeric Antigen Receptor T Cell Therapies for Cancer


  • Author : Daniel W. Lee
  • Publisher : Elsevier
  • Release Date : 2019-12-02
  • Genre: Uncategoriezed
  • Pages : 244
  • ISBN 10 : 0323661815
  • Total Read : 61
  • File Size : 9,8 Mb

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Chimeric Antigen Receptor T Cell Therapies for Cancer Summary:

From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area. Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy.

Chimeric Antigen Receptor T Cells Book

Chimeric Antigen Receptor T Cells


  • Author : Kamilla Swiech
  • Publisher : Humana
  • Release Date : 2020-11-24
  • Genre: Medical
  • Pages : 274
  • ISBN 10 : 1071601482
  • Total Read : 74
  • File Size : 5,5 Mb

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Chimeric Antigen Receptor T Cells Summary:

This volume provides comprehensive methods from expert scientists working in the Chimeric Antigen Receptor T Cell (CAR-T Cell) field. Chapters guide readers through the state-of-art of CAR-T cell technology, CAR design and vector production, CAR-T cell generation and manufacturing, CAR-T cell characterization, and quality control. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chimeric Antigen Receptor T Cells: Development and Production aims to be useful in the production of CAR-T cells, especially for therapeutic purposes.

Tumor Microenvironment Book

Tumor Microenvironment


  • Author : Peter P. Lee
  • Publisher : Springer Nature
  • Release Date : 2020-03-25
  • Genre: Medical
  • Pages : 326
  • ISBN 10 : 9783030388621
  • Total Read : 75
  • File Size : 10,8 Mb

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Tumor Microenvironment Summary:

This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers. Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.

Fast Facts  CAR T Cell Therapy Book

Fast Facts CAR T Cell Therapy


  • Author : Richard J. Buka
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2021-02-28
  • Genre: Medical
  • Pages : 71
  • ISBN 10 : 9783318067415
  • Total Read : 63
  • File Size : 6,8 Mb

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Fast Facts CAR T Cell Therapy Summary:

Chimeric antigen receptor (CAR) T cells are genetically engineered immune cells that can seek out and destroy cancer cells. The results from their use in cancer immunotherapy have been very promising, but treatment is often associated with frequent, serious short-term toxicities. 'Fast Facts: CAR-T Therapy' explains what CAR T cells are and how they were developed, discusses the results of clinical trials and the management of toxicities, and outlines future improvements and applications. It is ideal reading for any healthcare professional wanting to know more about this exciting therapeutic field. Table of Contents: • CAR T cells • Clinical application • Practical aspects • Future directions

The EBMT EHA CAR T Cell Handbook Book

The EBMT EHA CAR T Cell Handbook


  • Author : Nicolaus Kröger
  • Publisher : Springer Nature
  • Release Date : 2022-02-07
  • Genre: Medical
  • Pages : 237
  • ISBN 10 : 9783030943530
  • Total Read : 92
  • File Size : 20,7 Mb

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The EBMT EHA CAR T Cell Handbook Summary:

This first open access European CAR-T Handbook, co-promoted by the European Society for Blood and Marrow Transplantation (EBMT) and the European Hematology Association (EHA), covers several aspects of CAR-T cell treatments, including the underlying biology, indications, management of side-effects, access and manufacturing issues. This book, written by leading experts in the field to enhance readers’ knowledge and practice skills, provides an unparalleled overview of the CAR-T cell technology and its application in clinical care, to enhance readers’ knowledge and practice skills.

Immunotherapy of Hepatocellular Carcinoma Book

Immunotherapy of Hepatocellular Carcinoma


  • Author : Tim F. Greten
  • Publisher : Springer
  • Release Date : 2017-10-04
  • Genre: Medical
  • Pages : 167
  • ISBN 10 : 9783319649580
  • Total Read : 92
  • File Size : 14,7 Mb

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Immunotherapy of Hepatocellular Carcinoma Summary:

In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.