Chemical Biology of the Genome Book

Chemical Biology of the Genome


  • Author : Siddhartha Roy
  • Publisher : Academic Press
  • Release Date : 2021-05-14
  • Genre: Science
  • Pages : 352
  • ISBN 10 : 9780128176450
  • Total Read : 85
  • File Size : 5,6 Mb

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Chemical Biology of the Genome Summary:

Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods for study and analysis of the genome and epigenome, with an emphasis on relevance to physiological and pathophysiological processes and drug discovery. Authors and international leaders in biochemical studies of the genome, Drs. Siddhartha Roy and Tapas Kundu, adopt an integrated, interdisciplinary approach throughout, demonstrating how fast evolving chemical and mass-scale sequencing tools are increasingly used to interpret biochemical processes of the genome. Later sections discuss chemical modifications of the genome, DNA sequence recognition by proteins and gene regulation, GWAS and EpiGWAS studies, 3D architecture of the genome, and functional genome architecture. In-depth, discovery focused chapters examine intervention in gene networks using SiRNA/ShRNA, miRNA, and anti-miR, small molecule modulation of iPS, drug resistance pathways altered DNA methylation as drug targets, anti-miR as therapeutics, and nanodelivery of drugs. Offers an interdisciplinary discussion of the chemical biology of the genome and epigenome, employing illustrative case studies in both physiological and pathophysiological contexts Supports researchers in employing chemical and mass-scale sequencing approaches to interpret genomic and epigenomic dynamics Highlights innovative pathways and molecular targets for new disease study and drug discovery

Chemical Biology of the Genome Book

Chemical Biology of the Genome


  • Author : Siddhartha Roy
  • Publisher : Elsevier
  • Release Date : 2021-05-19
  • Genre: Science
  • Pages : 350
  • ISBN 10 : 9780128176443
  • Total Read : 59
  • File Size : 5,8 Mb

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Chemical Biology of the Genome Summary:

Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods for study and analysis of the genome and epigenome, with an emphasis on relevance to physiological and pathophysiological processes and drug discovery. Authors and international leaders in biochemical studies of the genome, Drs. Siddhartha Roy and Tapas Kundu, adopt an integrated, interdisciplinary approach throughout, demonstrating how fast evolving chemical and mass-scale sequencing tools are increasingly used to interpret biochemical processes of the genome. Later sections discuss chemical modifications of the genome, DNA sequence recognition by proteins and gene regulation, GWAS and EpiGWAS studies, 3D architecture of the genome, and functional genome architecture. In-depth, discovery focused chapters examine intervention in gene networks using SiRNA/ShRNA, miRNA, and anti-miR, small molecule modulation of iPS, drug resistance pathways altered DNA methylation as drug targets, anti-miR as therapeutics, and nanodelivery of drugs. Offers an interdisciplinary discussion of the chemical biology of the genome and epigenome, employing illustrative case studies in both physiological and pathophysiological contexts Supports researchers in employing chemical and mass-scale sequencing approaches to interpret genomic and epigenomic dynamics Highlights innovative pathways and molecular targets for new disease study and drug discovery

Advanced Chemical Biology Book

Advanced Chemical Biology


  • Author : Howard C. Hang
  • Publisher : John Wiley & Sons
  • Release Date : 2023-04-03
  • Genre: Science
  • Pages : 806
  • ISBN 10 : 9783527347339
  • Total Read : 91
  • File Size : 8,7 Mb

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Advanced Chemical Biology Summary:

Advanced Chemical Biology The modern approach to teaching chemical biology Advanced Chemical Biology is organized around the central dogma of life, progressing from genes to proteins and higher-order cellular structures, including core application areas such as imaging, chemical genetics, activity-based protein profiling, and natural product discovery and biosynthesis. Advanced topics and applications in, e. g., microbiology, developmental biology, and neurobiology, are covered in separate sections. Every chapter is homogeneous in style and layout, consisting of a short historical introduction followed by a description of the underlying concepts and a selection of recent examples of how the concept has been turned into practice. The subdivision of the contents into core and supplemental chapters enables a flexible use in teaching, both for a one-semester and a two-semester course. Written by authors and editors coming from the leading scientific institutions that have developed the concepts and technologies for this discipline, Advanced Chemical Biology includes specific information on topics like: DNA function, synthesis and engineering, chemical approaches to genome integrity, and RNA function, synthesis, and probing Chemical approaches to transcription and RNA regulation in vivo, chemical biology of genome engineering, and peptide/protein synthesis and engineering Directed evolution for chemical biology, chemical biology of cellular metabolism, chemical biology of lipids, and protein post-translational modifications Chemical glycobiology, chemical and enzymatic modification of proteins, genetic code expansion, bio-orthogonal chemistry, and cellular imaging With its broad scope and focus on turning concepts into applications, Advanced Chemical Biology is an excellent starting point for anyone entering the field and looking for a guide to the wide range of available methods and strategies that chemical biology has to offer. With a Foreword by Nobel Laureate Carolyn

The Chemical Biology of Long Noncoding RNAs Book

The Chemical Biology of Long Noncoding RNAs


  • Author : Stefan Jurga
  • Publisher : Springer Nature
  • Release Date : 2020-10-01
  • Genre: Medical
  • Pages : 545
  • ISBN 10 : 9783030447434
  • Total Read : 61
  • File Size : 7,5 Mb

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The Chemical Biology of Long Noncoding RNAs Summary:

This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.

Advancing Development of Synthetic Gene Regulators Book

Advancing Development of Synthetic Gene Regulators


  • Author : Anandhakumar Chandran
  • Publisher : Springer
  • Release Date : 2019-01-26
  • Genre: Science
  • Pages : 114
  • ISBN 10 : 9811348995
  • Total Read : 67
  • File Size : 16,8 Mb

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Advancing Development of Synthetic Gene Regulators Summary:

This book focuses on an “outside the box” notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)–N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates in a randomized DNA library. Their biological influences rely primarily on selective DNA binding affinity, so it is important to analyze their genome-wide binding preferences. However, it is demanding to enrich specifically the small-molecule-bound DNA without chemical cross-linking or covalent binding in chromatinized genomes. Herein is described a method that was developed using high-throughput sequencing to map the differential binding sites and relative enriched regions of non-cross-linked SAHA-PIPs throughout the complex human genome. SAHA-PIPs binding motifs were identified and the genome-level mapping of SAHA-PIPs-enriched regions provided evidence for the differential activation of the gene network. A method using high-throughput sequencing to map the binding sites and relative enriched regions of alkylating PIP throughout the human genome was also developed. The genome-level mapping of alkylating the PIP-enriched region and the binding sites on the human genome identifies significant genomic targets of breast cancer. It is anticipated that this pioneering low-cost, high through-put investigation at the sequence-specific level will be helpful in understanding the binding specificity of various DNA-binding small molecules, which in turn will be beneficial for the development of small-molecule-based drugs targeting a genome-level sequence.

Chemical Biology of Natural Products Book

Chemical Biology of Natural Products


  • Author : David J. Newman
  • Publisher : CRC Press
  • Release Date : 2017-09-22
  • Genre: Medical
  • Pages : 622
  • ISBN 10 : 9781351643283
  • Total Read : 78
  • File Size : 11,8 Mb

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Chemical Biology of Natural Products Summary:

Chemical Biology of Natural Products This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds. Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing authors presenting current examples from their own work in order to exemplify key themes. Topics covered in the text include genome mining, heterologous expression, natural product synthesis, biosynthesis, glycosylation, chemical ecology, and therapeutic applications of natural products, both current and potential.

CRISPR Book

CRISPR


  • Author : Rodolphe Barrangou
  • Publisher : John Wiley & Sons
  • Release Date : 2022-09-14
  • Genre: Science
  • Pages : 308
  • ISBN 10 : 9781683670377
  • Total Read : 94
  • File Size : 14,7 Mb

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CRISPR Summary:

“An excellent compendium of all things CRISPR from some of the leading minds in the field. With thorough coverage from every angle and beautifully detailed illustrations, this book is not to be missed!” Jennifer A. Doudna, Professor of Chemistry, Biochemistry & Molecular Biology, UC Berkeley; Founder, Innovative Genomics Institute; Nobel Laureate and coinventor of CRISPR technology “This journey through CRISPR biology and several of its breakthrough applications offers an exciting glimpse into one of the most beautiful and compelling fields in the life sciences.” David R. Liu, Director of the Merkin Institute at the Broad Institute of MIT and Harvard; Professor of Chemistry and Chemical Biology at Harvard University; coinventor of base editing and prime editing “A must read! The CRISPR topics, written by world-leading experts, span from the fascinating mechanistic underpinnings to the ingenious applications. One can read from start to finish or pick and choose themes. Either way, the book delivers utterly enjoyable learning!” Bonnie Bassler, Squibb Professor and Chair, Princeton University Department of Molecular Biology; Howard Hughes Medical Institute Investigator CRISPR-Cas systems have revolutionized the science of gene editing and their possible applications continue to expand, from basic research to potentially groundbreaking medical and commercial uses. Led by a distinguished team of editors, CRISPR: Biology and Applications explores the subject matter needed to delve into this fascinating area. Topics covered include: Classification and molecular mechanisms of CRISPR-Cas systems CRISPR-Cas evolution, regulation, expression, and function Uses for gene editing and modulation of gene expression CRISPR-based antimicrobials and phage resistance for medical and industrial purposes Written by internationally renowned authors, CRISPR: Biology and Applications serves as both an introductory guide for those new to the field and an authoritative reference f

Synthetic Biology Book

Synthetic Biology


  • Author : Fouad Sabry
  • Publisher : One Billion Knowledgeable
  • Release Date : 2022-10-05
  • Genre: Medical
  • Pages : 420
  • ISBN 10 : PKEY:6610000394135
  • Total Read : 91
  • File Size : 11,5 Mb

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Synthetic Biology Summary:

What Is Synthetic Biology The interdisciplinary field of study known as synthetic biology (SynBio) aims to either develop new biological components, gadgets, and systems or to redesign systems that are already present in nature. How You Will Benefit (I) Insights, and validations about the following topics: Chapter 1: Synthetic biology Chapter 2: Genetic engineering Chapter 3: Genetic code Chapter 4: Genome Chapter 5: Genomics Chapter 6: Xenobiology Chapter 7: Recombinant DNA Chapter 8: Chemical biology Chapter 9: Gene Chapter 10: Recombineering Chapter 11: Synthetic genomics Chapter 12: Artificial gene synthesis Chapter 13: Christopher Voigt Chapter 14: Expanded genetic code Chapter 15: Organism Chapter 16: Synthetic biological circuit Chapter 17: Genome editing Chapter 18: History of genetic engineering Chapter 19: Genetic engineering techniques Chapter 20: Minimal genome Chapter 21: CRISPR gene editing (II) Answering the public top questions about synthetic biology. (III) Real world examples for the usage of synthetic biology in many fields. (IV) 17 appendices to explain, briefly, 266 emerging technologies in each industry to have 360-degree full understanding of synthetic biology' technologies. Who This Book Is For Professionals, undergraduate and graduate students, enthusiasts, hobbyists, and those who want to go beyond basic knowledge or information for any kind of synthetic biology.