Genome Editing in Cardiovascular and Metabolic Diseases Book

Genome Editing in Cardiovascular and Metabolic Diseases


  • Author : Junjie Xiao
  • Publisher : Springer Nature
  • Release Date : 2023
  • Genre: Cardiovascular system
  • Pages : 338
  • ISBN 10 : 9789811956423
  • Total Read : 77
  • File Size : 8,8 Mb

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Genome Editing in Cardiovascular and Metabolic Diseases Summary:

This book provides the latest research progress on genome editing in cardiovascular and metabolic diseases and includes bioinformatics research methodology of genome editing. Genome editing is a genetic engineering technique precisely modified specific target genes of organism genome, which has been applied to basic theoretical research and production applications from plants and animals to gene therapy of human beings. Cardiovascular and metabolic diseases have become major factors affecting human health worldwide. This book contains information about bioinformatics, genome editing in cardiovascular diseases, genome editing in metabolic diseases and therapeutic effects. It will be useful for biologist, cardiologist, cardiovascular surgeons, endocrinologist, internists, nurses, undergraduate and graduate students in medicine and cell biology and others interested in cardiovascular and metabolic medicine.

Genome Editing Book

Genome Editing


  • Author : Kiran Musunuru
  • Publisher : Academic Press
  • Release Date : 2021-03-05
  • Genre: Medical
  • Pages : 230
  • ISBN 10 : 9780128236475
  • Total Read : 99
  • File Size : 8,9 Mb

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Genome Editing Summary:

Genome Editing: A Practical Guide to Research and Clinical Applications is geared towards investigators interested in learning how to use CRISPR-Cas9-based technologies, with a focus on cardiovascular research and clinical applications. Covering a range of topics from the basics of genome editing to design considerations, to assessments and applications, this reference allows readers to get started and establish a full workflow from the beginning of the project to its full completion. With worked examples drawn from real-life experiments, as well as troubleshooting and pitfalls to avoid, the book serves as an essential reference for researchers and investigators in both cardiovascular and biomedical research. Help readers familiarise with the variety of genome-editing approaches that are being applied in cardiovascular research and medicine, i.e., both research applications and clinical applications Understand the use of genome editing through worked examples (based on real-life experiments) in which CRISPR-Cas9 is employed, online tools to design CRISPR-Cas9 reagents, methods to interpret data from genome-editing experiments, the downsides of genome-editing technology - both the scientific and ethical pitfalls to avoid Written in an easy-to-follow manner, guiding readers from the design of the project to its completion Includes unpublished and new methods

Translational Cardiometabolic Genomic Medicine Book

Translational Cardiometabolic Genomic Medicine


  • Author : Annabelle Rodriguez-Oquendo
  • Publisher : Academic Press
  • Release Date : 2015-09-07
  • Genre: Science
  • Pages : 352
  • ISBN 10 : 9780128004746
  • Total Read : 94
  • File Size : 8,9 Mb

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Translational Cardiometabolic Genomic Medicine Summary:

Translational Cardiometabolic Genomic Medicine, edited by Dr. Annabelle Rodriguez-Oquendo, is an important resource to postgraduate (medical, dental and graduate) students, postdoctoral fellows, basic scientists, and physician scientists seeking to understand and expand their knowledge base in the field of genomic medicine as it is applied to cardiometabolic diseases. This handbook integrates cutting-edge experimental approaches such as chromatin immunoprecipitation paired end tagging (CHIA-PET), to population studies such as the Multi-Ethnic Study of Atherosclerosis. It encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome to the use of molecular diagnostic testing in predicting increased risk of cardiovascular diseases. Where applicable, this reference also includes chapters related to therapeutic options specifically aligned to molecular targets. Provides comprehensive research on translational genomic medicine Explains state-of-the-art genome editing for stem cells and mouse models with significant relevance to human cardiometabolic disease Includes discussions on the functional effects of single nucleotide polymorphisms and cardiometabolic diseases, stratified by sex and race Encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome

Genome Editing Book

Genome Editing


  • Author : Kursad Turksen
  • Publisher : Springer
  • Release Date : 2016-08-09
  • Genre: Science
  • Pages : 166
  • ISBN 10 : 9783319341484
  • Total Read : 82
  • File Size : 14,7 Mb

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Genome Editing Summary:

This timely volume explores the use of CRISPR-Cas9 for genome editing, presenting cutting-edge techniques and their applications in treatment of disease. The chapters describe latest methods such as use of targetable nucleases, investigation of the non-coding genome, mouse genome editing, increasing of knock-in efficiency in mouse zygotes, and generation of reporter stem cells; the text contextualizes these methods in treatment of cardiovascular disease, diabetes mellitus, retinitis pigmentosa, and others. The final chapters round out the book with a discussion of controversies and future directions. Genome Editing is an essential, of-the-moment contribution to this rapidly growing field. Drawing from a wealth of international perspectives, it presents novel techniques and applications for the engineering of the human genome. This book is essential reading for all clinicians and researchers in stem cells, regenerative medicine, genomics, biochemical and biomedical engineering- especially those interested in learning more about genome editing and applying it in a targeted, specific way.

Human Genome Editing Book

Human Genome Editing


  • Author : National Academies of Sciences, Engineering, and Medicine
  • Publisher : National Academies Press
  • Release Date : 2017-08-13
  • Genre: Medical
  • Pages : 329
  • ISBN 10 : 9780309452885
  • Total Read : 65
  • File Size : 12,9 Mb

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Human Genome Editing Summary:

Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Cardiovascular Genomics Book

Cardiovascular Genomics


  • Author : Mohan K. Raizada
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-02-24
  • Genre: Medical
  • Pages : 362
  • ISBN 10 : 9781592598830
  • Total Read : 64
  • File Size : 15,6 Mb

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Cardiovascular Genomics Summary:

Recognized scientists and clinicians from around the world discuss the most recent molecular approaches to understanding the cardiovascular system in both health and disease. The authors focus on all components of the system, including blood vessels, heart, kidneys, and the brain, and cover disease states ranging from vascular and cardiac dysfunction to stroke and hypertension. The methods described for identifying the genes that cause susceptibility to cardiovascular diseases emphasize the possibility of discovering new drug targets. Authoritative and ground-breaking, Cardiovascular Genomics offers an unprecedented examination of both the cutting-edge scientific approaches now possible and the results obtained from them in the new science of cardiovascular genomics.

Genome Editing and Engineering Book

Genome Editing and Engineering


  • Author : Krishnarao Appasani
  • Publisher : Cambridge University Press
  • Release Date : 2018-08-23
  • Genre: Science
  • Pages : 535
  • ISBN 10 : 9781107170377
  • Total Read : 86
  • File Size : 7,9 Mb

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Genome Editing and Engineering Summary:

A complete guide to endonuclease-based genomic engineering, from basic science to application in disease biology and clinical treatment.

Reprogramming the Genome  CRISPR Cas based Human Disease Therapy Book

Reprogramming the Genome CRISPR Cas based Human Disease Therapy


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2021-06-12
  • Genre: Science
  • Pages : 390
  • ISBN 10 : 9780323853248
  • Total Read : 66
  • File Size : 8,8 Mb

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Reprogramming the Genome CRISPR Cas based Human Disease Therapy Summary:

Reprogramming the Genome: CRISPR-Cas-based Human Disease Therapy, presents the collation of chapters written by eminent scientists worldwide. CRISPR-Cas9 is a key technology for targeted genome editing and regulation in a number of organisms including mammalian cells. It is a rapid, simple, and cost-effective solution. CRISPR-Cas system has recently gained much scientific and public attention. This volume covers CRISPR-Cas9 based mammalian genome editing, creating disease models, cancer therapy, neurological, heredity, blood disorders, defective gene correction, stem cells therapy, epigenetic modifications, patents, ethics, biosafety and regulatory issues challenges and opportunities. This book is a key source of information on mammalian genome editing available in a single volume. This book will be useful for beginners in mammalian genome editing and also students, researchers, scientists, policymakers, clinicians and stakeholders interested in genome editing in several areas. Offers basic understanding and a clear picture of mammalian genome editing through CRISPR-Cas systems Discusses how to create mammalian disease models, stem cell modification, epigenetic modifications, correction of defective gene in blood disorders, heredity, neurological disorders and many more Discusses the application of CRISPR-Cas9 systems in basic sciences, biomedicine, molecular biology, translational sciences, neurobiology, neurology, cancer, stem cells, and many more