Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy Book

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy


  • Author : Ganji Purnachandra Nagaraju, MSc, PhD
  • Publisher : Academic Press
  • Release Date : 2019-04-04
  • Genre: Science
  • Pages : 200
  • ISBN 10 : 012817661X
  • Total Read : 87
  • File Size : 16,5 Mb

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Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy Summary:

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy, edited by Dr. Nagaraju focuses on overriding the resistance from chemotherapeutic drugs with a broader range of treatment options. It particularly focuses on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways. This volume discusses topics such as pancreatic cancer biology, current therapeutic options, EMT, chemotherapy resistance mechanisms, and genetic manipulations and natural products to enhance the sensitivity of pancreatic cancer to chemotherapy. Additionally, it discusses small targeted molecules and pancreatic cancer trials, and nanotechnology-based drug delivery. Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy is a valuable source for researchers and advanced students in cancer and oncology as well as clinicians and medical students who are interested in learning more about ways to break pancreatic cancer resistance to chemotherapy. Modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property by introducing new strategies and drugs Provides information about on-going research as well as clinical data on pancreatic cancer and detailed descriptions about therapeutic options for easy understanding Utilizes full color figures to help the understanding of the content and tables for easy comparison of information as well as quick access to it

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy Book

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy


  • Author : Ganji Purnachandra Nagaraju
  • Publisher : Academic Press
  • Release Date : 2019-02-26
  • Genre: Science
  • Pages : 223
  • ISBN 10 : 9780128176627
  • Total Read : 93
  • File Size : 8,7 Mb

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Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy Summary:

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy edited by Dr. Nagaraju, PhD., DSc. focuses on overriding the resistance from chemotherapeutic drugs with a broader range of treatment options. It particularly focuses on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways. This volume discusses topics such as pancreatic cancer biology, current therapeutic options, EMT, chemotherapy resistance mechanisms, and genetic manipulations and natural products to enhance the sensitivity of pancreatic cancer to chemotherapy. Additionally, it discusses small targeted molecules and pancreatic cancer trials, and nanotechnology-based drug delivery. Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy is a valuable source for researchers and advanced students in cancer and oncology as well as clinicians and medical students who are interested in learning more about ways to break pancreatic cancer resistance to chemotherapy. Modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property by introducing new strategies and drugs Provides information about on-going research as well as clinical data on pancreatic cancer and detailed descriptions about therapeutic options for easy understanding Utilizes full color figures to help the understanding of the content and tables for easy comparison of information as well as quick access to it

NK Cells in Cancer Immunotherapy  Successes and Challenges Book

NK Cells in Cancer Immunotherapy Successes and Challenges


  • Author : Anahid Jewett
  • Publisher : Academic Press
  • Release Date : 2022-12-06
  • Genre: Science
  • Pages : 496
  • ISBN 10 : 9780128226261
  • Total Read : 72
  • File Size : 18,5 Mb

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NK Cells in Cancer Immunotherapy Successes and Challenges Summary:

NK Cells in Cancer Immunotherapy: Successes and Challenges explains the latest immunotherapeutic strategies, focusing on NK cells to allow the best and precise combination treatments to cancer patients. The book provides existing background knowledge in the field of immunotherapy and discusses future areas of research required to carry out cutting-edge, validated therapies. Chapters cover advances in immunotherapeutic strategies, in particular, the use of NK cells with and without T-cell therapy in the treatment of cancer. The book is a valuable resource for cancer researchers, oncologists, graduate students and those interested in learning more about novel strategies to treat cancer patients. Immunotherapy is fast becoming the method of choice for cancer therapy. Although remarkable advances have been made in the field of immunotherapy, there are significant challenges and difficulties ahead since many of the current immunotherapeutic strategies do not provide long-lasting treatment strategies, and therefore are not very effective. Covers CAR/T and CAR/NK and adoptive NK cell therapy with and without T cell therapies Discusses basic biology of NK cells and mouse models of human cancers and the role of NK cells in metastatic cancer and in cancer stem cells Encompasses information on combination therapies using check point inhibition, adoptive transfer of cytotoxic effector cells, chemotherapeutic drugs and activating and inhibitory antibodies

Immunotherapy in Resistant Cancer  From the Lab Bench Work to Its Clinical Perspectives Book

Immunotherapy in Resistant Cancer From the Lab Bench Work to Its Clinical Perspectives


  • Author : Jorge Morales Montor
  • Publisher : Academic Press
  • Release Date : 2020-10-01
  • Genre: Science
  • Pages : 288
  • ISBN 10 : 9780128220290
  • Total Read : 90
  • File Size : 10,6 Mb

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Immunotherapy in Resistant Cancer From the Lab Bench Work to Its Clinical Perspectives Summary:

Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives provides high level knowledge on detailed mechanisms of actions and biological interactions of different immune drugs, with an aim of offering researchers and clinicians cutting-edge therapies to overcome drug resistance. The book explains the latest immunotherapies for different types of cancer, helping users carry out research projects or create alternatives for drug development in the pharmaceutical industry. Topics discussed include the relationship between immunotherapy and macrophages, immune checkpoints in different types of cancer, immune cocktails in solid tumors, and immune-phenotyping. Additionally, the book presents basic and clinical data on immunoresistance and glycosylation. This book is a valuable source for cancer researchers, medical doctors, clinicians and members of the biomedical field who must understand certain mechanisms to fight cancer that is resistant to immunotherapy. Provides basic and clinical evidence based on molecular interactions and clinical studies to address the risks and benefits of cancer immunotherapy Presents the results of new immunotherapy trials, discussing the state-of-the-art in different types of cancer Discusses targeted therapies approved by the FDA, along with therapies with clinical potential used in basic studies

Immunotherapeutic Strategies for the Treatment of Glioma Book

Immunotherapeutic Strategies for the Treatment of Glioma


  • Author : Christopher Jackson
  • Publisher : Academic Press
  • Release Date : 2021-09-10
  • Genre: Science
  • Pages : 190
  • ISBN 10 : 9780128197561
  • Total Read : 87
  • File Size : 20,5 Mb

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Immunotherapeutic Strategies for the Treatment of Glioma Summary:

Immunotherapeutic Strategies for the Treatment of Glioma provides a review of the current state of immunotherapy for primary brain tumors. The topic is of interest to patients, clinicians, and researchers alike, particularly given the recent failure of large clinical trials. This book serves as an overview of the most promising approaches in the field and provides a foundation for considering novel and combination therapies moving forward. The book discusses several types of immunotherapies for glioma, such as peptide, dendritic cell and heat shock protein vaccines; immune checkpoint blockade; myeloid cells as target; oncolytic viruses; and CAR T cell therapy. Additionally, it discusses the mechanisms of immune suppression in patients and immunogenomics. This volume is a valuable source for cancer researchers, oncologists and several members of biomedical field who are interested in novel strategies to fight glioblastoma. Summarizes the work in immunotherapy for glioma to-date, including the available evidence from preclinical studies and clinical trials Reviews the challenges and successes of the most promising strategies for brain tumor immunotherapy Provides a foundation for considering novel and combination therapies moving forward

Improving the Therapeutic Ratio in Head and Neck Cancer Book

Improving the Therapeutic Ratio in Head and Neck Cancer


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-10-04
  • Genre: Science
  • Pages : 376
  • ISBN 10 : 9780128178690
  • Total Read : 87
  • File Size : 9,8 Mb

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Improving the Therapeutic Ratio in Head and Neck Cancer Summary:

Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites. Provides key scientific background for clinicians when developing novel clinical trials and important examples for basic scientists of the types of work required to move a concept from the lab to the clinic Presents consistent pathway diagrams in each chapter, thus making it easier to understand complicated pathways Includes chapter summaries of the critical next steps needed to move studies from their current state into practice changing clinical data

Cancer Immunotherapy at the Crossroads Book

Cancer Immunotherapy at the Crossroads


  • Author : James H. Finke
  • Publisher : Springer Science & Business Media
  • Release Date : 2003-11-24
  • Genre: Medical
  • Pages : 386
  • ISBN 10 : 9781592597437
  • Total Read : 96
  • File Size : 9,6 Mb

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Cancer Immunotherapy at the Crossroads Summary:

Leading investigators and clinicians detail the different mechanisms used by tumors to escape and impair the immune system and then spell out possible clinical strategies to prevent or reverse tumor-induced immune dysfunction. The authors review the mechanisms of immune dysfunction and evasion mechanisms in histologically diverse human tumors, focusing on tumor-induced molecular defects in T cells and antigen-presenting cells (dendritic cells and tumors), that may serve as biomarkers for patient prognosis. They discuss the means by which these immune functions may be protected or restored in order to more effectively support the process of tumor rejection in situ. Cutting-edge techniques are outlined with the capacity to monitor the strength and quality of patients' immune responses using immunocytometry, MHC-peptide tetramers combined with apoptosis assay, ELISPOT assay, and detection of MHC-TAA peptide complexes on tumor cells.

Cancer Vaccines and Immunotherapy Book

Cancer Vaccines and Immunotherapy


  • Author : Peter L. Stern
  • Publisher : Cambridge University Press
  • Release Date : 2000-08-17
  • Genre: Medical
  • Pages : 304
  • ISBN 10 : 0521622638
  • Total Read : 60
  • File Size : 17,6 Mb

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Cancer Vaccines and Immunotherapy Summary:

Rapid progress in the definition of tumor antigens, and improved immunization methods, bring effective cancer vaccines within reach. In this wide-ranging survey, leading clinicians and scientists review therapeutic cancer vaccine strategies against a variety of diseases and molecular targets. Intended for an interdisciplinary readership, their contributions cover the rationale, development, and implementation of vaccines in human cancer treatment, with specific reference to cancer of the cervix, breast, colon, bladder, and prostate, and to melanoma and lymphoma. They review target identification, delivery vectors and clinical trial design. The book begins and ends with lucid overviews from the editors, that discuss the most recent developments.