Biophysics of Mitochondria Book

Biophysics of Mitochondria

  • Author : Nikolai Vekshin
  • Publisher : Springer Nature
  • File Size : 19,7 Mb
  • Release Date : 2020-01-31
  • Genre: Science
  • Pages : 197
  • ISBN 10 : 9783030338534


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In this monograph, the author -Head researcher at the Institute of Cell Biophysics of Russian Academy of Sciences- discusses the results of his own long-term studies of mitochondria as well as alternative points of view and experiments of other important researchers in the field. The monograph contains the main aspects of mitochondrial research by a number of physical methods: fluorescence spectroscopy, UV-vis spectrophotometry, IR spectroscopy, light-scattering, optical microscopy, fluorescence microscopy, colorimetry, photobleaching, polarography, among others. The monograph is very useful for researchers and graduate students specializing in mitochondrial biophysics, biochemistry, molecular biology and cytology. The book was published in Russian in 2019 by Photon Publishers (Pushchino, Moscow region).

Molecular Basis for Mitochondrial Signaling Book

Molecular Basis for Mitochondrial Signaling

  • Author : Tatiana K. Rostovtseva
  • Publisher : Springer
  • File Size : 5,7 Mb
  • Release Date : 2017-05-12
  • Genre: Science
  • Pages : 386
  • ISBN 10 : 9783319555393


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This book covers recent advances in the study of structure, function, and regulation of metabolite, protein and ion translocating channels, and transporters in mitochondria. A wide array of cutting-edge methods are covered, ranging from electrophysiology and cell biology to bioinformatics, as well as structural, systems, and computational biology. At last, the molecular identity of two important channels in the mitochondrial inner membrane, the mitochondrial calcium uniporter and the mitochondrial permeability transition pore have been established. After years of work on the physiology and structure of VDAC channels in the mitochondrial outer membrane, there have been multiple discoveries on VDAC permeation and regulation by cytosolic proteins. Recent breakthroughs in structural studies of the mitochondrial cholesterol translocator reveal a set of novel unexpected features and provide essential clues for defining therapeutic strategies. Molecular Basis for Mitochondrial Signaling covers these and many more recent studies of mitochondria function, their communication with other organelles, and their critical roles in development, aging, and in a plethora of stressful or degenerative events. Authored by leading researchers in the field, this volume will be an indispensable reference resource for graduate students and academics working in related areas of biophysics and cell biology as well as for professionals within industry.

Mitochondria Book


  • Author : Stephen W. Schaffer
  • Publisher : Springer Science & Business Media
  • File Size : 14,8 Mb
  • Release Date : 2010-02-24
  • Genre: Science
  • Pages : 359
  • ISBN 10 : 9780387699455


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This book is indispensable to researchers in fields as diverse as Molecular Biology and Biophysics. It covers the important role that mitochondria play in a variety of biochemical spheres. It analyses how mitochondria affect metabolic pathways, how they are active in the regulation of cytosolic constituents, and their role in initiating signal pathways. Also covered are the way mitochondria help to regulate apoptosis, and how they modulate cellular hypertrophy and proliferation. It gives an overview of the emergence of mitochondria as an important regulator of cell signaling, with a particular focus on their pathophysiology.

Mitochondrial Regulation Book

Mitochondrial Regulation

  • Author : Carlos M. Palmeira
  • Publisher : Humana
  • File Size : 7,6 Mb
  • Release Date : 2021-06-08
  • Genre: Science
  • Pages : 318
  • ISBN 10 : 1071614320


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This fully updated edition explores the different pathways that converge into the regulation of mitochondrial function. The book integrates mitochondria with other cellular components, discussing the dynamic properties of mitochondria with an emphasis on how these processes respond to signaling events and how they affect cellular metabolism. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Mitochondrial Regulation: Methods and Protocols, Second Edition is an ideal guide for advanced undergraduates, graduates, postgraduates, and beginning researchers in the areas of molecular and cellular biology, biochemistry, and bioenergetics.

Molecular Biology of Mitochondrial Transport Systems Book

Molecular Biology of Mitochondrial Transport Systems

  • Author : Michael Forte
  • Publisher : Springer Science & Business Media
  • File Size : 10,8 Mb
  • Release Date : 2013-06-29
  • Genre: Science
  • Pages : 408
  • ISBN 10 : 9783642789366


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Mitochondrial transport systems are essential to mitochondrial function and therefore to energy homeostasis within the cell. The book contains studies utilizing the techniques of biochemistry, physiology, molecular biology and genetics to reveal the structure and function of mitochondrial transport systems. It is divided into the following six sections: - Proton Translocation: The Uncoupling Protein and the ATPase; - Carriers and Transporters; - Mitochondrial Ion Channels; Structure of the Outer Mitochondrial Membrane Channel, VDAC; - VDAC, Peripheral Kinases and Energy Utilization; - Mitochondrial Channels in Humans and Relationship to Disease.

The Molecular Biology of Chloroplasts and Mitochondria in Chlamydomonas Book

The Molecular Biology of Chloroplasts and Mitochondria in Chlamydomonas

  • Author : J.-D. Rochaix
  • Publisher : Springer Science & Business Media
  • File Size : 12,8 Mb
  • Release Date : 2006-04-11
  • Genre: Science
  • Pages : 733
  • ISBN 10 : 9780306482045


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Provides a thorough overview of current research with the green alga Chlamydomonas on chloroplast and mitochondrial biogenesis and function, with an emphasis on the assembly and structure-function relationships of the constituents of the photosynthetic apparatus. Contributions emphasize the multidisciplinary nature of current research in photosynthesis, combining molecular genetics, biochemical, biophysical, and physiological approaches. The 36 articles address topics including nuclear genome organization; RNA stability and processing; splicing; translation; protein targeting in the chloroplast; photosystems; pigments; glycerolipids; the ATP synthase; and ferrodoxin and thioredoxin. Further contributions address new measurements methods for photosynthetic activity in vivo; starch biosynthesis; the responses of Chlamydomonas to various stress conditions; nitrogen assimilation; and mitochondrial genetics. Annotation copyrighted by Book News, Inc., Portland, OR

Molecular Mechanisms in Bioenergetics Book

Molecular Mechanisms in Bioenergetics

  • Author : L. Ernster
  • Publisher : Elsevier
  • File Size : 12,6 Mb
  • Release Date : 1992-12-16
  • Genre: Science
  • Pages : 520
  • ISBN 10 : 0080860834


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This book summarises current knowledge of the structure, function,biosynthesis and regulation of energy-transducing enzymes inmitochondria, chloroplasts and bacteria. Each of the twenty chapters is written by top experts in their field, and Prof. Ernster has ensured that the book as a whole gives a well-integrated picture of the present state of knowledge of the field at its different levels and complexities. Since the publication of Bioenergetics edited by Lars Ernster in 1984, (New Comprehensive Biochemistry Vol. 9) the whole field of bioenergetics has undergone a tremendous expansion. Additionally a transition from membrane bioenergetics to molecular bioenergetics has accompanied this expansion - due mainly to the spectacular progress in the field of molecular biology over the past twenty years. Hence this volume, Molecular Mechanisms in Bioenergetics, is certain to be of interest, not only to the specialist in bioenergetics, but also to researchers working in the various fields of biophysics, biochemistry, molecular biology, genetics, cell biology and physiology. Also of interest, this volume contains an historical introduction, including a list of earlier publications relating to the history of bioenergetics.

Frontiers of Cellular Bioenergetics Book

Frontiers of Cellular Bioenergetics

  • Author : S. Papa
  • Publisher : Springer Science & Business Media
  • File Size : 19,9 Mb
  • Release Date : 2012-12-06
  • Genre: Science
  • Pages : 801
  • ISBN 10 : 9781461548430


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1. The Mitochondrial and Bacterial Respiratory Chains: From MacMunn and Keilin to Current Concepts; P. Nicholls. 2. The Mitochondrial Enzymes of Oxidative Phosphorylation; Y. Hatefi. 3. Proton Pumps of Respiratory Chain Enzymes; S. Papa, et al. 4. Uncoupling of Respiration and Phosphorylation; V.P. Skulachev. 5. Crystallization, Structure, and Possible Mechanism of Action of Cytochrome c Oxidase from the Soil Bacterium Paracoccus denitrificans; M. Hartmut, et al. 6. The Structure of Crystalline Bovine Heart Cytochrome c Oxidase; S. Yoshikawa, et al. 7. Electron and Proton Transfer in.

Principles of Bioenergetics Book

Principles of Bioenergetics

  • Author : Vladimir P. Skulachev
  • Publisher : Springer Science & Business Media
  • File Size : 10,7 Mb
  • Release Date : 2012-12-15
  • Genre: Science
  • Pages : 435
  • ISBN 10 : 9783642334306


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Principles of Bioenergetics summarizes one of the quickly growing branches of modern biochemistry. Bioenergetics concerns energy transductions occurring in living systems and this book pays special attention to molecular mechanisms of these processes. The main subject of the book is the "energy coupling membrane" which refers to inner membranes of intracellular organelles, for example, mitochondria and chloroplasts. Cellular cytoplasmic membranes where respiratory and photosynthetic energy transducers, as well as ion-transporting ATP-synthases (ATPases) are also part of this membrane. Significant attention is paid to the alternative function of mitochondria as generators of reactive oxygen species (ROS) that mediate programmed death of cells (apoptosis and necrosis) and organisms (phenoptosis). The latter process is considered as a key mechanism of aging which may be suppressed by mitochondria-targeted antioxidants.

Molecular Basis of Mitochondrial Pathology Book

Molecular Basis of Mitochondrial Pathology

  • Author : C. P. Lee
  • Publisher : Academic Press
  • File Size : 14,9 Mb
  • Release Date : 2014-11-27
  • Genre: Science
  • Pages : 254
  • ISBN 10 : 9781483297835


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The field of mitochondrial diseases is currently one of the rapidly growing fields of research in cell and molecular biology. This volume encompasses the latest development in this field of research. The chapters cover topics in a wide range of disciplines including biophysics, biochemistry, cell and molecular biology, molecular genetics, and clinical medicine. Summarizes growing evidence of the role of mitochondria in a large number of pathological conditions Brings together different approaches toward understanding mitochondria diseases Molecular and cellular biology Clinical physiology and medicine Details the crucial role this organelle plays in genetic regulation of various biological functions

Bioenergetics of the Cell  Quantitative Aspects Book

Bioenergetics of the Cell Quantitative Aspects

  • Author : Valdur A. Saks
  • Publisher : Springer Science & Business Media
  • File Size : 17,7 Mb
  • Release Date : 2012-12-06
  • Genre: Science
  • Pages : 460
  • ISBN 10 : 9781461556534


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This volume continues the discussion of the problems of in vivo and in vitro. The recently solved X-ray structure of the mitochondrial creatine kinase and its molecular biology cellular bioenergetics - the tradition we started in 1994 by publication of the focused issue of Molecular and Cellular are analyzed with respect to its molecular physiology and Biochemistry, volume 133/134 and a book 'Cellular Bio functional coupling to the adenine nucleotide translocase, as energetics: role of coupled creatine kinases' edited by V. Saks well as its participation, together with the adenylate kinase and R. Ventura-Clapier and published by Kluwer Publishers, system, in intracellular energy transfer. The results of the Dordrecht -Boston. In the present volume, use of quantitative studies of creatine kinase deficient transgenic mice are methods of studies of organized metabolic systems, such as summarized and analyzed by using mathematical models of mathematical modeling and Metabolic Control Analysis, for the compartmentalized energy transfer, thus combining two investigation of the problems of bioenergetics of the cell is powerful new methods of the research. All these results, described together with presentation of new experimental together with the physiological and NMR data on the cardiac results. The following central problems of the cellular bio metabolic and mitochondrial responses to work-load changes energetics are the focus of the discussions: the mechanisms concord to the concept of metabolic networks of energy of regulation of oxidative phosphorylation in the cells in vivo transfer and feedback regulation.

Taurine 4 Book

Taurine 4

  • Author : Laura Della Corte
  • Publisher : Springer Science & Business Media
  • File Size : 20,8 Mb
  • Release Date : 2005-12-07
  • Genre: Science
  • Pages : 647
  • ISBN 10 : 9780306468384


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Mitochondria from mammalian tissues possess an elaborate system for 2+ 2+ transporting Ca across their inner membrane which consists of Ca import, 2+ via the Ca uniporter, in response to the mitochondrial membrane 2+ + potential ?? and of Ca release by an antiport system in exchange for H + 9,23 or Na (see Fig. l) . Because the uniporter is dependent upon the external 2+ 2+ 2+ 2+ Ca concentration ([Ca ]), mitochondria accumulate Ca until the [Ca ] o o 2+ decreases to the level at which the uniporter activity balances the Ca efflux. 2+ The [Ca ] at which the uniporter and efflux activities are equal is defined o the “setpoint” andcorresponds to values between 0.3-3μM. 2+ Figure 1. The Ca transport system of the inner membrane of mammalian mitochondria. U, + 2+ + + uniporter. I, Na -independent efflux mechanism or Ca /2H exchanger. D, Na -dependent 2+ + efflux mechanism or Ca /2Na exchanger. PTP, permeability transition pore. FP, 11 flavoprotein. ?? membrane potential. ? pH gradient. Adapted from .

Bioenergetics 3 Book

Bioenergetics 3

  • Author : David G. Nicholls
  • Publisher : Gulf Professional Publishing
  • File Size : 16,5 Mb
  • Release Date : 2002
  • Genre: Science
  • Pages : 334
  • ISBN 10 : 0125181213


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This new edition of Bioenergetics presents a clear and up-to-date explanation of the chemiosmotic theory and covers mitochondria, bacteria, and chloroplasts. It takes account of the many newly determined structures, such as ATP synthase and the two photosystems of photosynthesis, that provide molecular insight into chemiosmotic energy transduction. This edition includes additional color figures of protein structures and many newly drawn illustrations designed to enable the reader to grasp the fundamental insights that are derived from knowing the structure. Every chapter has been extensively revised and updated and a new chapter on the study of the bioenergetics of mitochondria in the intact cell is included to satisfy the enormous interest in this topic. Written for students and researchers alike, this book is the most current text on the chemiosmotic theory and membrane bioenergetics available. Key Features * Chapter on the study of bioenergetics of mitochondria in the intact cell * Appendix listing protein structure resources * Additional colour plates of protein structures * Many newly drawn illustrations * Website

Mitochondria Book


  • Author : Immo E. Scheffler
  • Publisher : Wiley-Liss
  • File Size : 6,6 Mb
  • Release Date : 2008
  • Genre: Science
  • Pages : 500
  • ISBN 10 : UVA:X030256854


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This book is the eagerly awaited second edition of the best-selling Mitochondria, a book widely acknowledged as the first modern, truly comprehensive authored work on the important, scientifically fundamental topic of the cellular organelles known as mitochondria. This new edition brings readers completely up to date on the many significant findings that have occurred in the eight years since the book was first published. As in that seminal first edition, the second edition tackles the biochemistry, genetics, and pathology of mitochondria in different organisms. The new edition provides thorough updates of all literature concerning this vital organelle, its functions, ongoing research surrounding it, and its importance vis-à-vis a broad range of issues in cellular and molecular biology. The book includes detailed descriptions of current and developing technologies around mitochondrial research and discovery, and highlights subjects that are growing, such as the use of proteomics. -- Publisher.