Autophagy in Immune Response  Impact on Cancer Immunotherapy Book

Autophagy in Immune Response Impact on Cancer Immunotherapy


  • Author : Salem Chouaib
  • Publisher : Academic Press
  • Release Date : 2020-05-25
  • Genre: Science
  • Pages : 242
  • ISBN 10 : 9780128196090
  • Total Read : 92
  • File Size : 10,5 Mb

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Autophagy in Immune Response Impact on Cancer Immunotherapy Summary:

Autophagy in Immune Response: Impact on Cancer Immunotherapy focuses on the status and future directions of autophagy with respect to different aspects of its interaction with the immune system and immunotherapy. The book takes scientific research in autophagy a step further by presenting reputable information on the topic and offering integrated content with advancements in autophagy, from cell biology and biochemical research, to clinical treatments. This book is a valuable source for cancer researchers, oncologists, graduate students and several members of biomedical field who are interested in learning more on the relationship between autophagy and immunotherapies. Presents updated knowledge on autophagy at the basic level and its potential use in cancer treatment Offers the first book to cover autophagy at the interface of cell biology, immunology and tumor biology Provides a wealth of information on the topic in a coherent and comprehensive collection of contributions by world renowned scientists and investigators

Autophagy  Cancer  Other Pathologies  Inflammation  Immunity  Infection  and Aging Book

Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging


  • Author : M. A. Hayat
  • Publisher : Academic Press
  • Release Date : 2016-12-28
  • Genre: Medical
  • Pages : 430
  • ISBN 10 : 9780128094273
  • Total Read : 61
  • File Size : 16,9 Mb

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Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging Summary:

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

Glioma Book

Glioma


  • Author : ryuya yamanaka
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-05-27
  • Genre: Medical
  • Pages : 232
  • ISBN 10 : 9781461431466
  • Total Read : 85
  • File Size : 16,6 Mb

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Glioma Summary:

Treatment of glioma is currently one of the most challenging problems in oncology, as well as in neurosurgery. Despite major advances in our understanding of the pathomechanism, diagnosis by imaging and the availability of powerful therapeutic tools, the life expectancy of patients with glioblastoma has only been slightly prolonged and a cure remains elusive. None of the currently available surgical tools, including operative microscopes, lasers and image-guided surgery, can enable the detection and removal of all of the tumor tissue. In recent years, however, the landscape has been changing immeasurably, and molecular studies over the past two decades have identified a variety of genetic aberrations that are specifically associated with individual types of gliomas. In addition, certain molecular abnormalities have been linked to therapy responses, thereby establishing clinical biomarkers and molecular targets, and the use of novel agents is being investigated. These agents have been specifically engineered to exert specific cytotoxicity against gliomas, either on their own as single agents or in combination with other modalities. Moreover, there has been an enormous surge of interest in the area of immunology and immunotherapy, which has been facilitated by our understanding of the molecular basis of gliomas. Although several kinds of immunotherapeutic trials have been undertaken, we still await a great breakthrough in terms of clinical efficacy to prolong the survival time of glioma patients.

Autophagy in tumor and tumor microenvironment Book

Autophagy in tumor and tumor microenvironment


  • Author : Sujit Kumar Bhutia
  • Publisher : Springer Nature
  • Release Date : 2020-10-24
  • Genre: Medical
  • Pages : 280
  • ISBN 10 : 9789811569302
  • Total Read : 80
  • File Size : 6,6 Mb

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Autophagy in tumor and tumor microenvironment Summary:

This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.

Inflammation and Cancer Book

Inflammation and Cancer


  • Author : Bharat B. Aggarwal
  • Publisher : Springer
  • Release Date : 2014-05-12
  • Genre: Medical
  • Pages : 490
  • ISBN 10 : 9783034808378
  • Total Read : 85
  • File Size : 12,7 Mb

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Inflammation and Cancer Summary:

This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Microbial Crosstalk with Immune System Book

Microbial Crosstalk with Immune System


  • Author : Asmita Das
  • Publisher : Elsevier
  • Release Date : 2022-07-29
  • Genre: Medical
  • Pages : 272
  • ISBN 10 : 9780323961288
  • Total Read : 69
  • File Size : 10,8 Mb

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Microbial Crosstalk with Immune System Summary:

Our body is not sterile and harbors enumerable microflora that are now being understood to play a complex role in immune regulation and shaping of the immune system in a continuous and dynamic way. In 8 chapters, Microbial Crosstalk with Immune System: New Insights in Therapeutics provides an overall introduction with special focus on how the immune system which is specifically geared to get rid of non-self-antigens, allows numerous microbes to colonize the human body. In the presence of microbes there are several observations that suggest that there are multiple roles that are played by these microbes in tumor progression and shaping of our immune system which is explained at length in subsequent chapters. Microbial Crosstalk with Immune System: New Insights in Therapeutics discusses the emerging mechanisms of immune-therapeutics as well as its limitations while emphasizing the potential role of microbes in shaping immune-therapeutic and evolving novel strategies to deal with any limitations. Focuses on the modulation of immune system by the microbiome, thus affecting cancer prognosis Discusses various current research strategies in the field that are still in experimental stages. enabling readers to gain a perspective on the ongoing research in the field Gives insight into the emerging mechanisms of immune-therapeutics and its limitations Emphasizes the potential role of microbes in shaping immune-therapeutics

NK Cells in Cancer Immunotherapy  Successes and Challenges Book

NK Cells in Cancer Immunotherapy Successes and Challenges


  • Author : Anahid Jewett
  • Publisher : Academic Press
  • Release Date : 2022-12-06
  • Genre: Science
  • Pages : 496
  • ISBN 10 : 9780128226261
  • Total Read : 79
  • File Size : 13,7 Mb

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NK Cells in Cancer Immunotherapy Successes and Challenges Summary:

NK Cells in Cancer Immunotherapy: Successes and Challenges explains the latest immunotherapeutic strategies, focusing on NK cells to allow the best and precise combination treatments to cancer patients. The book provides existing background knowledge in the field of immunotherapy and discusses future areas of research required to carry out cutting-edge, validated therapies. Chapters cover advances in immunotherapeutic strategies, in particular, the use of NK cells with and without T-cell therapy in the treatment of cancer. The book is a valuable resource for cancer researchers, oncologists, graduate students and those interested in learning more about novel strategies to treat cancer patients. Immunotherapy is fast becoming the method of choice for cancer therapy. Although remarkable advances have been made in the field of immunotherapy, there are significant challenges and difficulties ahead since many of the current immunotherapeutic strategies do not provide long-lasting treatment strategies, and therefore are not very effective. Covers CAR/T and CAR/NK and adoptive NK cell therapy with and without T cell therapies Discusses basic biology of NK cells and mouse models of human cancers and the role of NK cells in metastatic cancer and in cancer stem cells Encompasses information on combination therapies using check point inhibition, adoptive transfer of cytotoxic effector cells, chemotherapeutic drugs and activating and inhibitory antibodies

Adoptive Cell Transfer Book

Adoptive Cell Transfer


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2022-07-15
  • Genre: Science
  • Pages : 204
  • ISBN 10 : 9780323994071
  • Total Read : 87
  • File Size : 16,9 Mb

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Adoptive Cell Transfer Summary:

Adoptive Cell Transfer, Volume 370 in the International Review of Cell and Molecular Biology series highlights advances in the field, with this new volume presenting interesting chapters written by an international board of authors who expound on topics such as the Impact of tumor microenvironment on Adoptive Cell Transfer activity, Dendritic Cell Transfer, CAR-T Cell dysfunction and exhaustion, NK Cell-based cancer immunotherapy, Enabling CAR-T cells for solid tumors: rage against the suppressive tumor microenvironment, Improving Adoptive T-Cell therapy with cytokines administration, and What will (and should) be improved in Immunotherapy with CAR? Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists and drawn from international sources Offers a wide range of perspectives on specific subjects