Oligomerization and Allosteric Modulation in G Protein Coupled Receptors Book

Oligomerization and Allosteric Modulation in G Protein Coupled Receptors


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2012-12-02
  • Genre: Science
  • Pages : 488
  • ISBN 10 : 9780123947918
  • Total Read : 80
  • File Size : 18,5 Mb

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Oligomerization and Allosteric Modulation in G Protein Coupled Receptors Summary:

In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology. Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research. Contributions from leading authorities Informs and updates on all the latest developments in the field

Protein Allostery in Drug Discovery Book

Protein Allostery in Drug Discovery


  • Author : Jian Zhang
  • Publisher : Springer Nature
  • Release Date : 2019-11-09
  • Genre: Medical
  • Pages : 384
  • ISBN 10 : 9789811387197
  • Total Read : 60
  • File Size : 9,9 Mb

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Protein Allostery in Drug Discovery Summary:

The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc.

From Structure to Clinical Development  Allosteric Modulation of G Protein Coupled Receptors Book

From Structure to Clinical Development Allosteric Modulation of G Protein Coupled Receptors


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-05-13
  • Genre: Medical
  • Pages : 328
  • ISBN 10 : 9780128201886
  • Total Read : 91
  • File Size : 6,5 Mb

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From Structure to Clinical Development Allosteric Modulation of G Protein Coupled Receptors Summary:

From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo-switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP-1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction, RAMPs as allosteric modulators of Class B GPCRs, Structure-based discovery and development of mGlu5 NAMs, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

From Structure to Clinical Development  Allosteric Modulation of G Protein Coupled Receptors Book

From Structure to Clinical Development Allosteric Modulation of G Protein Coupled Receptors


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-05-22
  • Genre: Medical
  • Pages : 328
  • ISBN 10 : 9780128201879
  • Total Read : 76
  • File Size : 16,8 Mb

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From Structure to Clinical Development Allosteric Modulation of G Protein Coupled Receptors Summary:

From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo-switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP-1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction, RAMPs as allosteric modulators of Class B GPCRs, Structure-based discovery and development of mGlu5 NAMs, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Allosteric Modulation of G Protein Coupled Receptors Book

Allosteric Modulation of G Protein Coupled Receptors


  • Author : Robert Laprairie
  • Publisher : Elsevier
  • Release Date : 2022-02-10
  • Genre: Business & Economics
  • Pages : 212
  • ISBN 10 : 9780128197714
  • Total Read : 61
  • File Size : 5,7 Mb

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Allosteric Modulation of G Protein Coupled Receptors Summary:

Allosteric Modulation of G Protein-Coupled Receptors reviews fundamental information on G protein-coupled receptors (GPCRs) and allosteric modulation, presenting original research in the area and collectively providing a comprehensive description of key issues in GPCR allosteric modulation. The book provides background on core concepts of molecular pharmacology while also introducing the most important advances and studies in the area. It also discusses key methodologies. This is an essential book for researchers and advanced students engaged in pharmacology, toxicology and pharmaceutical sciences training and research. Many of the GPCR-targeted drugs released in the past decade have specifically worked via allosteric mechanisms. Unlike direct orthosteric-acting compounds that occupy a similar receptor site to that of endogenous ligands, allosteric modulators alter GPCR-dependent signaling at a site apart from the endogenous ligand. Recent methodological and analytical advances have greatly improved our ability to understand the signaling mechanisms of GPCRs. We now know that allostery is a common regulatory mechanism for all GPCRs and not - as we once believed - unique to a few receptor subfamilies. Introduces background on core concepts of molecular pharmacology, including statistical analyses, non-linear regression, complex models and GPCR-dependent signal transduction as they relate to allosteric modulation Discusses critical advances and landmark studies, including discoveries in the area of GPCR allosteric modulation, which are reviewed for their importance in positive and negative regulation, protein-protein interactions, and small molecule drug discovery Includes key methodologies used to study allosteric modulation at the in silico, in vitro, and in vivo levels of drug discovery and characterization

Receptor Receptor Interactions Book

Receptor Receptor Interactions


  • Author : Kjell Fuxe
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-03-13
  • Genre: Computers
  • Pages : 580
  • ISBN 10 : 9781468454154
  • Total Read : 90
  • File Size : 12,9 Mb

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Receptor Receptor Interactions Summary:

Allosterism in Drug Discovery Book

Allosterism in Drug Discovery


  • Author : Dario Doller
  • Publisher : Royal Society of Chemistry
  • Release Date : 2016-11-24
  • Genre: Medical
  • Pages : 458
  • ISBN 10 : 9781782624592
  • Total Read : 86
  • File Size : 19,9 Mb

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Allosterism in Drug Discovery Summary:

Although the concept of allosterism has been known for over half a century, its application in drug discovery has exploded in recent years. The emergence of novel technologies that enable molecular-level ligand-receptor interactions to be studied in studied in unprecedented detail has driven this trend. This book, written by the leaders in this young research area, describes the latest developments in allosterism for drug discovery. Bringing together research in a diverse range of scientific disciplines, Allosterism in Drug Discovery is a key reference for academics and industrialists interested in understanding allosteric interactions. The book provides an in-depth review of research using small molecules as chemical probes and drug candidates that interact allosterically with proteins of relevance to life sciences and human disease. Knowledge of these interactions can then be applied in the discovery of the novel therapeutics of the future. This book will be useful for people working in all disciplines associated with drug discovery in academia or industry, as well as postgraduate students who may be working in the design of allosteric modulators.

Molecular Pharmacology Book

Molecular Pharmacology


  • Author : Angel Catala
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-12-16
  • Genre: Medical
  • Pages : 168
  • ISBN 10 : 9781839629310
  • Total Read : 87
  • File Size : 11,6 Mb

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Molecular Pharmacology Summary:

This book concentrates on recent developments related to the application of original structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology as well as basic pharmacological problems that offer mechanistic insights that are generally significant for the field of pharmacology. Written by experts, chapters cover such topics as drug transport mechanisms and drug–receptor complexes. This volume offers up-to-date, expert reviews of the fast-moving field of molecular pharmacology.